| LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR. | LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR.
Xie XM, Cao QL, Sun YJ, Zhang J, Liu KL, Qin YF, Long WJ, Luo ZJ, Li XW, Liang XH, Yuan GD, Luo XP, Xuan XP. | 05/15/2023 |
| Changes of LRP6/beta-catenin pathway in adipose tissue of rats with intrauterine growth restriction with catch-up growth. | Changes of LRP6/β-catenin pathway in adipose tissue of rats with intrauterine growth restriction with catch-up growth.
Cao Q, Li X, Xuan X, Huang S, Xie X., Free PMC Article | 04/2/2022 |
| LRP6 regulates alternative pre-mRNA splicing. | Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing.
Yuan T, Wang S, Hu C, Wu Y, Liang D, Li L, Liu Y, Li J, Chen YH., Free PMC Article | 11/23/2019 |
| knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes. | Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation.
Chen Z, Li Y, Jiang G, Yang C, Wang Y, Wang X, Fang B, Zhang G, Sun Y, Qian J, Gong H, Zou Y. | 10/13/2018 |
| LRP6 acts as a scaffold protein in cardiac gap junction assembly and intracellular protein trafficking. | LRP6 acts as a scaffold protein in cardiac gap junction assembly.
Li J, Li C, Liang D, Lv F, Yuan T, The E, Ma X, Wu Y, Zhen L, Xie D, Wang S, Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L, Lin L, Peng L, Cui J, Zhu W, Chen YH., Free PMC Article | 08/25/2018 |
| Authors demonstrate for the first time novel neuroprotective function of REST in prion diseases and hypothesise that the LRP6-Wnt-beta-catenin/REST signaling plays critical and collaborative roles in neuroprotection. | REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D., Free PMC Article | 12/16/2017 |
| GSK3beta is activated and p-LRP6 is down-regulated in kidneys of diabetic rats. These abnormalities were prevented by treatment with green tea. | Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.
Peixoto EB, Papadimitriou A, Teixeira DA, Montemurro C, Duarte DA, Silva KC, Joazeiro PP, Lopes de Faria JM, Lopes de Faria JB. | 02/13/2016 |
| study demonstrates that LRP5/6 mediates pulmonary vascular remodeling and PH in hyperoxia-induced neonatal lung injury | Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S. | 12/21/2013 |
| Traumatic brain injury caused a rapid, but transient, increase in LRP6 phosphorylation that is followed by a modest decrease in ss-Catenin phosphorylation. Phospho-GSK-3beta immunoreactivity was found to increase three days post injury. | Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
Dash PK, Johnson D, Clark J, Orsi SA, Zhang M, Zhao J, Grill RJ, Moore AN, Pati S., Free PMC Article | 03/3/2012 |
| SERPINA3K is a high-affinity, endogenous antagonist of LRP6 | Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.
Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX., Free PMC Article | 05/31/2010 |
| DKK1 inhibition of LRP6 is independent of LRP6 internalization and degradation | DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
Semënov MV, Zhang X, He X., Free PMC Article | 01/21/2010 |