| Fas2 has function(s) other than homophilic adhesion. | The Drosophila NCAM homolog Fas2 signals independently of adhesion.
Neuert H, Deing P, Krukkert K, Naffin E, Steffes G, Risse B, Silies M, Klämbt C. | 07/4/2020 |
| Study identifies Fas2 as miR-210's target in circadian regulation. Fas2 abundance is increased in fly brain lacking of miR-210 suggesting that Fas2 expression is inhibited by miR-210 determining the phase of evening anticipatory behavior. | miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2.
Niu Y, Liu Z, Nian X, Xu X, Zhang Y., Free PMC Article | 12/21/2019 |
| Fas2-mediated intermicrovillar homophilic adhesion complexes help stabilize the brush border. | The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.
Halberg KA, Rainey SM, Veland IR, Neuert H, Dornan AJ, Klämbt C, Davies SA, Dow JA., Free PMC Article | 09/17/2016 |
| Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII. | C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
Spring AM, Brusich DJ, Frank CA., Free PMC Article | 07/30/2016 |
| Fas 2 is linked to core clock by Mef2 and influences circadian cycle within pacemaker neurons; Mef2 is required for this daily fasciculation-defasciculation cycle | The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior.
Sivachenko A, Li Y, Abruzzi KC, Rosbash M., Free PMC Article | 10/19/2013 |
| the expression of Adf-1 targets Staufen and Fasciclin II (FasII), identified through larval brain ChIP-Seq for Adf-1, is negatively regulated by Adf-1, and manipulations of these genes predictably modify dendrite growth. | The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity.
Timmerman C, Suppiah S, Gurudatta BV, Yang J, Banerjee C, Sandstrom DJ, Corces VG, Sanyal S., Free PMC Article | 09/28/2013 |
| Together with our results suggesting that DmRet and DmGfrl do not function in cis in Drosophila, which lacks GDNF ligands, these data imply that DmGfrl may be an evolutionarily ancient binding partner for NCAM/FasII. | Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.
Kallijärvi J, Stratoulias V, Virtanen K, Hietakangas V, Heino TI, Saarma M., Free PMC Article | 06/29/2013 |
| The inability of Tao mutant cells to shorten their membranes is caused by the accumulation of the cell adhesion molecule Fasciclin 2. | Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis.
Gomez JM, Wang Y, Riechmann V., Free PMC Article | 02/23/2013 |
| this FasII isoform has unique functions in synaptic development independent of transsynaptic adhesion. beag and dsmu1 mutants demonstrate an essential role for these previously uncharacterized splicing factors in the regulation of synapse development | Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.
Beck ES, Gasque G, Imlach WL, Jiao W, Jiwon Choi B, Wu PS, Kraushar ML, McCabe BD., Free PMC Article | 07/28/2012 |
| Loss of fas2 interacts with genetic conditions that perturb EGFR signalling. Fas2 is expressed in patterns during imaginal disc development, and in eye we have shown that this depends on EGFR activity, implying participation in a negative-feedback loop. | Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling.
Mao Y, Freeman M., Free PMC Article | 01/21/2010 |
| Fas2 mediates trans-synaptic adhesion, which contributes to postsynaptic molecular assembly at the onset of synaptogenesis. | In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2.
Kohsaka H, Takasu E, Nose A., Free PMC Article | 01/21/2010 |
| Data show that fasciclin 2 directs cluster asymmetry essential for timing delamination of epithelial cells from the epithelium in preparation for migration. | A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility.
Szafranski P, Goode S. | 01/21/2010 |
| Fas II functions to restrict branch length and arbor expanse during development of innervation to the Dorsal Longitudinal (flight) Muscle | A role for Fas II in the stabilization of motor neuron branches during pruning in Drosophila.
Hebbar S, Fernandes JJ. | 01/21/2010 |
| Drosophila larval neuromuscular junction to investigate the pathways activated by Fasciclin II (FasII) | Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint.
Ashley J, Packard M, Ataman B, Budnik V., Free PMC Article | 01/21/2010 |
| integrins act through CaMKII activation to control the localization of Fasciclin 2 in the development of NMJ synaptic morphology | Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development.
Beumer K, Matthies HJ, Bradshaw A, Broadie K. | 01/21/2010 |
| Fas2(spin) rotation defects are linked to an abnormal endocrine function and an elevated level of juvenile hormone. | The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila.
Adám G, Perrimon N, Noselli S. | 01/21/2010 |