Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1alpha and Nuclear Receptor Coactivator-1. | Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1α and Nuclear Receptor Coactivator-1. Liao C, Liu Y, Lin Y, Wang J, Zhou T, Weng W. | 10/1/2024 |
Reduced levels of endogenous SRC-1 and apoA-IV expression are responsible for the impaired E2's anorectic action in obese females. | Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. Shen L, Liu Y, Tso P, Wang DQ, Davidson WS, Woods SC, Liu M., Free PMC Article | 02/16/2019 |
In post-traumatic avoiders, predator-odor exposure led to lower SRC-1 expression in paraventricular nucleus and central amygdala, and higher expression in the ventral hippocampus. | Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats. Whitaker AM, Farooq MA, Edwards S, Gilpin NW., Free PMC Article | 09/24/2016 |
results provided the first evidence that SRC-1 mediated endogenous estrogen regulation of hippocampal synaptic plasticity by targeting the expression of synaptic protein PSD-95 | Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats. Liu M, Huangfu X, Zhao Y, Zhang D, Zhang J. | 01/23/2016 |
Age-related decrease of SRC-1 in specific motor, learning, and memory nuclei suggests its potential roles in neurodegenerative disorders, which may be one of the underlying mechanisms of the vulnerability of the aged brain. | Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats. Zhang D, Guo Q, Bian C, Zhang J, Lin S, Su B. | 11/19/2011 |
Results showed that hippocampal SRC-1 is regulated by postnatal development but not ovariectomy. | Expression of steroid receptor coactivator-1 was regulated by postnatal development but not ovariectomy in the hippocampus of rats. Zhang D, Guo Q, Bian C, Zhang J, Cai W, Su B. | 07/16/2011 |
Age-induced loss of PPARgamma/steroid receptor coactivator-1 interactions increased the binding of PPARgamma to the promoter of the adipogenic gene aP2. | Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1. Miard S, Dombrowski L, Carter S, Boivin L, Picard F. | 01/21/2010 |
interactions of SRC-1 from brain with progestin and estrogen receptors are dependent on ligand, receptor subtype, and brain region to manifest the pleiotropic functional consequences that underlie steroid-regulated behaviors | Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes. Molenda-Figueira HA, Murphy SD, Shea KL, Siegal NK, Zhao Y, Chadwick JG Jr, Denner LA, Tetel MJ., Free PMC Article | 01/21/2010 |
the effects of colchicine (COL) and/or all-trans retinoic acid (ATRA) on expression of rexinoid receptors (RXRs) (alpha, beta, gamma), thyroid hormone receptor alpha and coregulators N-CoR, SMRT and SRC-1 mRNA in primary rat hepatocytes was investigated. | The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes. Macejová D, Dvorák Z, Vrzal R, Ulrichová J, Ondková S, Brtko J. | 01/21/2010 |
These results support a model where VDR preferentially recruits SRC-1 to enhance bone-specific OC gene transcription. | 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. Carvallo L, Henríquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. | 01/21/2010 |
Infusion of antisense oligodeoxynucleotides to SRC-1 mRNA into the VMN decreased estrogen receptor-dependent lordosis intensity and reduced progesterone receptor-dependent ear wiggling and hopping and darting. | Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats. Molenda-Figueira HA, Williams CA, Griffin AL, Rutledge EM, Blaustein JD, Tetel MJ., Free PMC Article | 01/21/2010 |
In seminiferous tubules of mature rat testis, SRC-1 and TRAM-1 immunoreactivity was found predominantly in spermatogonia and spermatocytes. In the epididymis, SRC-1 and TIF2 immunoreactivities were localized in nuclei of epithelial cells. | Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K. | 01/21/2010 |
Data show that steroid receptor coactivator-1 (SRC-1) overexpressing cells are more responsive to Po mRNA induction by dihydroprogesterone (DHP) than SRC-1-deficient cells, and that DHP treatment increases not only Po but also SRC-1 mRNA levels. | SRC-1 is involved in the control of the gene expression of myelin protein Po. Cavarretta IT, Martini L, Motta M, Smith CL, Melcangi RC. | 01/21/2010 |
SRC-1 splice variants differentially affect corticosteroid receptor signaling | Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER. | 01/21/2010 |
Results suggest a sexual dimorphism in the content of progesterone receptors, estrogen receptor-beta, and SMRT, but not SRC-1, in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol. | Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats. González-Arenas A, Neri-Gómez T, Guerra-Araiza C, Camacho-Arroyo I. | 01/21/2010 |
SRC-1 was predominant in neurons of the superficial laminae of the dorsal horn and within motorneurons of lamina IX. | SRC-1 localisation in lumbosacral spinal cord of male and female Wistar rats. Ranson RN, Santer RM, Watson AH. | 01/21/2010 |
specific protein-DNA and protein-protein interactions that occur within the context of the OC gene promoter in osteoblastic cells stabilize the preferential association of the VDR-SRC-1 complex | The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M., Free PMC Article | 01/21/2010 |
the findings clearly implicate dual regulation of ERalpha-dependent function by SRC-1 and SRC-2 in the intact female brain [SRC-1] | Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Apostolakis EM, Ramamurphy M, Zhou D, Oñate S, O'Malley BW. | 01/21/2010 |