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    Ncoa1 nuclear receptor coactivator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313929, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1alpha and Nuclear Receptor Coactivator-1.

    Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1α and Nuclear Receptor Coactivator-1.
    Liao C, Liu Y, Lin Y, Wang J, Zhou T, Weng W.

    10/1/2024
    Reduced levels of endogenous SRC-1 and apoA-IV expression are responsible for the impaired E2's anorectic action in obese females.

    Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.
    Shen L, Liu Y, Tso P, Wang DQ, Davidson WS, Woods SC, Liu M., Free PMC Article

    02/16/2019
    In post-traumatic avoiders, predator-odor exposure led to lower SRC-1 expression in paraventricular nucleus and central amygdala, and higher expression in the ventral hippocampus.

    Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats.
    Whitaker AM, Farooq MA, Edwards S, Gilpin NW., Free PMC Article

    09/24/2016
    results provided the first evidence that SRC-1 mediated endogenous estrogen regulation of hippocampal synaptic plasticity by targeting the expression of synaptic protein PSD-95

    Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats.
    Liu M, Huangfu X, Zhao Y, Zhang D, Zhang J.

    01/23/2016
    Age-related decrease of SRC-1 in specific motor, learning, and memory nuclei suggests its potential roles in neurodegenerative disorders, which may be one of the underlying mechanisms of the vulnerability of the aged brain.

    Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats.
    Zhang D, Guo Q, Bian C, Zhang J, Lin S, Su B.

    11/19/2011
    Results showed that hippocampal SRC-1 is regulated by postnatal development but not ovariectomy.

    Expression of steroid receptor coactivator-1 was regulated by postnatal development but not ovariectomy in the hippocampus of rats.
    Zhang D, Guo Q, Bian C, Zhang J, Cai W, Su B.

    07/16/2011
    Age-induced loss of PPARgamma/steroid receptor coactivator-1 interactions increased the binding of PPARgamma to the promoter of the adipogenic gene aP2.

    Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1.
    Miard S, Dombrowski L, Carter S, Boivin L, Picard F.

    01/21/2010
    interactions of SRC-1 from brain with progestin and estrogen receptors are dependent on ligand, receptor subtype, and brain region to manifest the pleiotropic functional consequences that underlie steroid-regulated behaviors

    Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes.
    Molenda-Figueira HA, Murphy SD, Shea KL, Siegal NK, Zhao Y, Chadwick JG Jr, Denner LA, Tetel MJ., Free PMC Article

    01/21/2010
    the effects of colchicine (COL) and/or all-trans retinoic acid (ATRA) on expression of rexinoid receptors (RXRs) (alpha, beta, gamma), thyroid hormone receptor alpha and coregulators N-CoR, SMRT and SRC-1 mRNA in primary rat hepatocytes was investigated.

    The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes.
    Macejová D, Dvorák Z, Vrzal R, Ulrichová J, Ondková S, Brtko J.

    01/21/2010
    These results support a model where VDR preferentially recruits SRC-1 to enhance bone-specific OC gene transcription.

    1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex.
    Carvallo L, Henríquez B, Paredes R, Olate J, Onate S, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M.

    01/21/2010
    Infusion of antisense oligodeoxynucleotides to SRC-1 mRNA into the VMN decreased estrogen receptor-dependent lordosis intensity and reduced progesterone receptor-dependent ear wiggling and hopping and darting.

    Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats.
    Molenda-Figueira HA, Williams CA, Griffin AL, Rutledge EM, Blaustein JD, Tetel MJ., Free PMC Article

    01/21/2010
    In seminiferous tubules of mature rat testis, SRC-1 and TRAM-1 immunoreactivity was found predominantly in spermatogonia and spermatocytes. In the epididymis, SRC-1 and TIF2 immunoreactivities were localized in nuclei of epithelial cells.

    Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis.
    Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K.

    01/21/2010
    Data show that steroid receptor coactivator-1 (SRC-1) overexpressing cells are more responsive to Po mRNA induction by dihydroprogesterone (DHP) than SRC-1-deficient cells, and that DHP treatment increases not only Po but also SRC-1 mRNA levels.

    SRC-1 is involved in the control of the gene expression of myelin protein Po.
    Cavarretta IT, Martini L, Motta M, Smith CL, Melcangi RC.

    01/21/2010
    SRC-1 splice variants differentially affect corticosteroid receptor signaling

    Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling.
    Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER.

    01/21/2010
    Results suggest a sexual dimorphism in the content of progesterone receptors, estrogen receptor-beta, and SMRT, but not SRC-1, in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol.

    Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats.
    González-Arenas A, Neri-Gómez T, Guerra-Araiza C, Camacho-Arroyo I.

    01/21/2010
    SRC-1 was predominant in neurons of the superficial laminae of the dorsal horn and within motorneurons of lamina IX.

    SRC-1 localisation in lumbosacral spinal cord of male and female Wistar rats.
    Ranson RN, Santer RM, Watson AH.

    01/21/2010
    specific protein-DNA and protein-protein interactions that occur within the context of the OC gene promoter in osteoblastic cells stabilize the preferential association of the VDR-SRC-1 complex

    The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene.
    Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M., Free PMC Article

    01/21/2010
    the findings clearly implicate dual regulation of ERalpha-dependent function by SRC-1 and SRC-2 in the intact female brain [SRC-1]

    Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice.
    Apostolakis EM, Ramamurphy M, Zhou D, Oñate S, O'Malley BW.

    01/21/2010
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