| OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline. | OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline.
Benner L, Muron S, Gomez JG, Oliver B., Free PMC Article | 09/25/2024 |
| Here, the authors show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitin-ligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning. | The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning.
Ray S, Rosenberg MI, Chanut-Delalande H, Decaras A, Schwertner B, Toubiana W, Auman T, Schnellhammer I, Teuscher M, Valenti P, Khila A, Klingler M, Payre F., Free PMC Article | 04/4/2020 |
| Transcription sites of the full svb cis-regulatory region inserted into a different chromosome colocalized with the svb locus, increasing Ubx concentration, the transcriptional output of svb, and partially rescuing the phenotype. | Multi-enhancer transcriptional hubs confer phenotypic robustness.
Tsai A, Alves MR, Crocker J., Free PMC Article | 02/22/2020 |
| Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis | Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis.
Bohère J, Mancheno-Ferris A, Al Hayek S, Zanet J, Valenti P, Akino K, Yamabe Y, Inagaki S, Chanut-Delalande H, Plaza S, Kageyama Y, Osman D, Polesello C, Payre F., Free PMC Article | 01/5/2019 |
| Co-expressing ectopic SoxN with svb rescued diverse denticle morphologies. Conversely, removing SoxN activity eliminated the residual denticles found in svb mutant embryos. Furthermore, several known Svb target genes are also activated by SoxN, and we have discovered two novel target genes of SoxN that are expressed in denticle-producing cells and that are regulated independently of Svb. | SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.
Rizzo NP, Bejsovec A., Free PMC Article | 09/23/2017 |
| Report the high-resolution functional dissection of a robust enhancer of the shavenbaby gene that has contributed to morphological evolution. We found that robustness is encoded by many binding sites for the transcriptional activator Arrowhead and that, during evolution, some of these activator sites were lost, weakening enhancer activity. | Evolved Repression Overcomes Enhancer Robustness.
Preger-Ben Noon E, Davis FP, Stern DL. | 06/24/2017 |
| Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila. These low affinity sites conferred specificity for Ubx binding in vivo, but multiple clustered sites were required for robust expression when embryos developed in variable environments. | Low affinity binding site clusters confer hox specificity and regulatory robustness.
Crocker J, Abe N, Rinaldi L, McGregor AP, Frankel N, Wang S, Alsawadi A, Valenti P, Plaza S, Payre F, Mann RS, Stern DL., Free PMC Article | 04/11/2015 |
| Multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo. | The structure and evolution of cis-regulatory regions: the shavenbaby story.
Stern DL, Frankel N., Free PMC Article | 07/12/2014 |
| study shows peptides of 11 to 32 amino acids encoded by polished rice(pri)sORF gene control epidermal differentiation by modifying Shavenbaby (Svb); Pri peptides trigger amino-terminal truncation of Svb which converts Svb from a repressor to an activator | Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Kondo T, Plaza S, Zanet J, Benrabah E, Valenti P, Hashimoto Y, Kobayashi S, Payre F, Kageyama Y. | 08/9/2010 |
| Results show that the embryonic expression of dsc73 requires Shavenbaby, a transcription factor regulating cuticle formation. | Expression of the Drosophila secreted cuticle protein 73 (dsc73) requires Shavenbaby.
Andrew DJ, Baker BS., Free PMC Article | 01/21/2010 |
| SoxN is necessary and sufficient to cell-autonomously direct the expression of svb. | The Drosophila HMG-domain proteins SoxNeuro and Dichaete direct trichome formation via the activation of shavenbaby and the restriction of Wingless pathway activity.
Overton PM, Chia W, Buescher M. | 01/21/2010 |
| identification of three distinct svb enhancers from D. melanogaster driving reporter gene expression in partly overlapping patterns that together recapitulate endogenous svb expression. | Morphological evolution through multiple cis-regulatory mutations at a single gene.
McGregor AP, Orgogozo V, Delon I, Zanet J, Srinivasan DG, Payre F, Stern DL. | 01/21/2010 |
| genetic and gene expression data show regulatory changes of the shavenbaby/ovo (svb/ovo) gene underlie independent cases of morphological convergence | Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism.
Sucena E, Delon I, Jones I, Payre F, Stern DL. | 01/21/2010 |
| shavenbaby governs an evolutionarily conserved developmental module consisting of a set of genes collectively responsible for trichome formation | Shavenbaby couples patterning to epidermal cell shape control.
Chanut-Delalande H, Fernandes I, Roch F, Payre F, Plaza S., Free PMC Article | 01/21/2010 |
| ovo-B is strongly expressed in the 2X germ cells in either a male or a female soma (ovo-B) | Sex determination signals control ovo-B transcription in Drosophila melanogaster germ cells.
Andrews J, Oliver B., Free PMC Article | 01/21/2010 |