| Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4. | Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4.
Zhao L, Wang Z, Chen H, Du Y, Ma W, Tao Q, Ma X, Wu Z, Peng J., Free PMC Article | 04/19/2023 |
| EphA4/ephrinA3 reverse signaling mediated downregulation of glutamate transporter GLAST in Muller cells in an experimental glaucoma model. | EphA4/ephrinA3 reverse signaling mediated downregulation of glutamate transporter GLAST in Müller cells in an experimental glaucoma model.
Zhou ZX, Xu LJ, Wang HN, Cheng S, Li F, Miao Y, Lei B, Gao F, Wang Z. | 01/28/2023 |
| Nogo-A-Delta20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling. | Nogo-A-Δ20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling.
Wang JL, Chen WG, Zhang JJ, Xu CJ. | 11/27/2021 |
| EphA4 is highly expressed in the atria of heart and its deletion leads to atrial hypertrophy and electrocardiographic abnormalities in rats. | EphA4 is highly expressed in the atria of heart and its deletion leads to atrial hypertrophy and electrocardiographic abnormalities in rats.
Li J, Dong W, Gao X, Chen W, Sun C, Li J, Gao S, Zhang Y, He J, Lu D, Jiang R, Ma M, Wang X, Zhang L. | 07/3/2021 |
| n the present study, we demonstrated that EphA4 receptor potentiated the activity of outwardly rectifying chloride channel in rat hippocampal neurons after ischemia-reperfusion | EphA4 receptor regulates outwardly rectifying chloride channel in CA1 hippocampal neurons after ischemia-reperfusion.
Li J, Ma N, Chen J, Yan D, Zhang Q, Shi J., Free PMC Article | 07/11/2020 |
| In myelinating co-cultures and in zebrafish, we find that the number of mature oligodendrocytes does not change as result of manipulating signaling through the ephrinA1-EphA4 system. However, in both systems, inhibition of EphA4 signaling leads to a higher number of myelin sheaths formed by each oligodendrocyte. In isolated oligodendrocyte cultures, activation of EphA4 reduced process extension. | Ephrin-A1-EphA4 signaling negatively regulates myelination in the central nervous system.
Harboe M, Torvund-Jensen J, Kjaer-Sorensen K, Laursen LS. | 10/27/2018 |
| Exosomal miR-10a might accelerate liver regeneration through downregulation of EphA4. | Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4.
Luo L, Yu ZP, Qin H, Zhu ZX, Liao MH, Liao HT, Yuan KF, Zeng Y., Free PMC Article | 09/8/2018 |
| EphrinA4 is involved in regulation of neuronal morphogenesis. | EphrinA4 mimetic peptide targeted to EphA binding site impairs the formation of long-term fear memory in lateral amygdala.
Dines M, Lamprecht R., Free PMC Article | 11/7/2015 |
| EphA4 mediates the inhibitory effect on Schwann cell migration, and EphA4 knock-down can strongly increase Schwann cell migration and peripheral nerve regeneration. | Inhibition of EphA4 expression promotes Schwann cell migration and peripheral nerve regeneration.
Wang Y, Zheng Z, Hu D. | 02/8/2014 |
| The kinase activity of EphA4, via activation of downstream Cdk5 activity, mediates the scaling-down of excitatory synaptic strength. | The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5.
Peng YR, Hou ZH, Yu X. | 10/19/2013 |
| Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation | Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons.
Li J, Liu N, Wang Y, Wang R, Guo D, Zhang C. | 10/6/2012 |
| These findings suggest the involvement of cell-cell EphA4 and ephrin-B2 signaling in establishing order in the developing inferior colliculus | EphA4 and ephrin-B2 expression patterns during inferior colliculus projection shaping prior to experience.
Gabriele ML, Brubaker DQ, Chamberlain KA, Kross KM, Simpson NS, Kavianpour SM. | 04/23/2011 |
| Results describe the cellular and subcellular localization of EphA4 in postnatal rat hippocampus by light and electron microscopic immunocytochemistry. | Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus.
Tremblay ME, Riad M, Chierzi S, Murai KK, Pasquale EB, Doucet G. | 01/21/2010 |
| These results suggest that blocking EphA4 is likely to contribute to a future successful clinical treatment for spinal cord injury. | Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.
Fabes J, Anderson P, Brennan C, Bolsover S. | 01/21/2010 |
| identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology | Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.
Shi L, Fu WY, Hung KW, Porchetta C, Hall C, Fu AK, Ip NY., Free PMC Article | 01/21/2010 |
| The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP. | Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus.
Tremblay ME, Riad M, Bouvier D, Murai KK, Pasquale EB, Descarries L, Doucet G. | 01/21/2010 |