| Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease. | Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease.
Husain RA, Jiao X, Hennings JC, Giesecke J, Palsule G, Beck-Wödl S, Osmanović D, Bjørgo K, Mir A, Ilyas M, Abbasi SM, Efthymiou S, Dominik N, Maroofian R, Houlden H, Rankin J, Pagnamenta AT, Nashabat M, Altwaijri W, Alfadhel M, Umair M, Khouj E, Reardon W, El-Hattab AW, Mekki M, Houge G, Beetz C, Bauer P, Putoux A, Lesca G, Sanlaville D, Alkuraya FS, Taylor RW, Mentzel HJ, Hübner CA, Huppke P, Hart RP, Haack TB, Kiledjian M, Rubio I., | 04/10/2024 |
| Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma. | Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma.
Hidmi S, Nechushtan H, Razin E, Tshori S., Free PMC Article | 09/11/2023 |
| NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. | NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A., Free PMC Article | 01/8/2022 |
| NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control. | Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization.
Kwon O, Kwak D, Ha SH, Jeon H, Park M, Chang Y, Suh PG, Ryu SH. | 12/2/2017 |
| Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. | NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.
Marriott AS, Vasieva O, Fang Y, Copeland NA, McLennan AG, Jones NJ., Free PMC Article | 07/22/2017 |
| This paper presents the crystal structure of wild-type and E58A mutant human Ap4A hydrolase. | Crystal structure of wild-type and mutant human Ap4A hydrolase.
Ge H, Chen X, Yang W, Niu L, Teng M., Free PMC Article | 09/21/2013 |
| High NUDT2 is associated with breast carcinoma. | Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation.
Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, Akahira J, Ishida T, Watanabe M, Hirakawa H, Ohuchi N, Sasano H. | 04/23/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| In this study the authors present data demonstrating that the SARS-CoV 7a protein interacts with human Ap4A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17). | SARS coronavirus protein 7a interacts with human Ap4A-hydrolase.
Vasilenko N, Moshynskyy I, Zakhartchouk A., Free PMC Article | 05/3/2010 |
| NMR resonance assignments | 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.
Swarbrick JD, Buyya S, Gunawardana D, Fletcher JI, Branson K, Smith B, Pepe S, McLennan AG, Gayler KR, Gooley PR. | 01/21/2010 |
| crystallographic structure and substrate-binding mechanism of Ap4A hydrolase | Structure and substrate-binding mechanism of human Ap4A hydrolase.
Swarbrick JD, Buyya S, Gunawardana D, Gayler KR, McLennan AG, Gooley PR. | 01/21/2010 |