| The nuclear activity of the actin-binding Moesin protein is necessary for gene expression in Drosophila. | The nuclear activity of the actin-binding Moesin protein is necessary for gene expression in Drosophila.
Bajusz C, Kristó I, Abonyi C, Venit T, Vedelek V, Lukácsovich T, Farkas A, Borkúti P, Kovács Z, Bajusz I, Marton A, Vizler C, Lipinszki Z, Sinka R, Percipalle P, Vilmos P. | 09/11/2021 |
| Data yet indicate that Moe is not directly involved in the stabilization of adherens junctions, but instead it mainly acts to regulate the apical cell perimeter during pupal wing morphogenesis. | Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.
Salis P, Payre F, Valenti P, Bazellieres E, Le Bivic A, Mottola G., Free PMC Article | 07/20/2019 |
| Moesin is a novel apical polarity protein that drives cortical remodeling of dividing neuroblasts, which is essential for polarity maintenance and initial establishment of cell size asymmetry. | Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division.
Abeysundara N, Simmonds AJ, Hughes SC., Free PMC Article | 01/12/2019 |
| These results indicate a critical role for Moesin in both neuronal morphogenesis and long-term memory formation. | The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila.
Freymuth PS, Fitzsimons HL., Free PMC Article | 05/12/2018 |
| The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export | The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.
Kristó I, Bajusz C, Borsos BN, Pankotai T, Dopie J, Jankovics F, Vartiainen MK, Erdélyi M, Vilmos P. | 12/9/2017 |
| Data show that Moesin upregulation influences extra-centrosome behavior and robust bipolar spindle formation. | Moesin is a major regulator of centrosome behavior in epithelial cells with extra centrosomes.
Sabino D, Gogendeau D, Gambarotto D, Nano M, Pennetier C, Dingli F, Arras G, Loew D, Basto R., Free PMC Article | 01/16/2016 |
| Btsz and Moesin guide luminal membrane morphogenesis through organizing actin. | Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.
JayaNandanan N, Mathew R, Leptin M., Free PMC Article | 11/28/2015 |
| The conserved C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of the kinase in epithelial cells, is not required for Moesin phosphorylation but is critical for the growth-promoting function of Slik. | Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation.
Panneton V, Nath A, Sader F, Delaunay N, Pelletier A, Maier D, Oh K, Hipfner DR., Free PMC Article | 11/21/2015 |
| Early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moesin, which in turn regulates seamless tube shape through modulation of cortical actin filaments. | Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin.
Schottenfeld-Roames J, Rosa JB, Ghabrial AS., Free PMC Article | 04/4/2015 |
| Moesin interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity. | Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.
Neisch AL, Formstecher E, Fehon RG., Free PMC Article | 11/16/2013 |
| Moesin stabilizes microtubules via a direct interaction at the cell cortex. | The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.
Solinet S, Mahmud K, Stewman SF, Ben El Kadhi K, Decelle B, Talje L, Ma A, Kwok BH, Carreno S., Free PMC Article | 09/28/2013 |
| Wgn-Moe signaling cascade plays a key role in photoreceptor target field innervations through cell autonomous and non-cell autonomous mechanisms. | Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.
Ruan W, Unsain N, Desbarats J, Fon EA, Barker PA., Free PMC Article | 09/21/2013 |
| Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin. | The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
Yang Y, Primrose DA, Leung AC, Fitzsimmons RB, McDermand MC, Missellbrook A, Haskins J, Smylie AS, Hughes SC. | 02/18/2012 |
| This study revealed a novel mechanism for controlling salivary gland lumen size, namely through Rho1-dependent actin polymerization and distribution and downregulation of apical phosphorylated moesin. | Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.
Xu N, Bagumian G, Galiano M, Myat MM., Free PMC Article | 01/28/2012 |
| the Pp1-87B phosphatase restricts high Moesin activity to early mitosis and down-regulates Moesin at the polar cortex, after anaphase onset. | Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.
Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, Payre F, Carreno S., Free PMC Article | 11/19/2011 |
| Epithelial cell without moesin show reduced cortical actin cytoskeleton, lack of junctional markers, detach from and migrate out of the epithelium suggesting a role of moesin in the stabilization of the apical-junctional domain. (Review) | Emerging role for ERM proteins in cell adhesion and migration.
Arpin M, Chirivino D, Naba A, Zwaenepoel I., Free PMC Article | 08/13/2011 |
| PtdIns(4,5)P(2) binding is essential for moesin recruitment to the membrane and for its subsequent phosphorylation. | Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation during Drosophila development.
Roch F, Polesello C, Roubinet C, Martin M, Roy C, Valenti P, Carreno S, Mangeat P, Payre F. | 09/6/2010 |
| Live imaging reveals that the Drosophila actin-binding ERM protein, moesin, co-localizes with the mitotic spindle. | Live imaging reveals that the Drosophila actin-binding ERM protein, moesin, co-localizes with the mitotic spindle.
Vilmos P, Jankovics F, Szathmári M, Lukácsovich T, Henn L, Erdélyi M. | 01/21/2010 |
| Results provide evidence that Dmoe RNA is a target of Lark during oogenesis and that it likely regulates either the splicing or translation of this RNA. | The Drosophila RNA-binding protein Lark is required for localization of Dmoesin to the oocyte cortex during oogenesis.
McNeil GP, Kaur M, Purrier S, Kang R. | 01/21/2010 |
| These findings suggest that Ribbon and Lola Like function as a novel transcriptional cassette coordinating molecular changes at the apical membrane of epithelial cells to facilitate tube elongation. | Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.
Kerman BE, Cheshire AM, Myat MM, Andrew DJ., Free PMC Article | 01/21/2010 |
| our results demonstrate a role for moesin in regulating synaptic growth in the Drosophila neuromuscular junction. | Moesin helps to restrain synaptic growth at the Drosophila neuromuscular junction.
Seabrooke S, Stewart BA. | 01/21/2010 |
| Changes in the activity and localization of Moesin that accompany mitotic progression contribute to the establishment of a stiff, rounded cortex at metaphase and to polar relaxation at anaphase. | Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis.
Kunda P, Pelling AE, Liu T, Baum B. | 01/21/2010 |
| We propose that the spatiotemporal control of moesin activation at the mitotic cortex provides localized cues to coordinate cortical contractility and microtubule interactions during cell division. | Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.
Carreno S, Kouranti I, Glusman ES, Fuller MT, Echard A, Payre F., Free PMC Article | 01/21/2010 |
| rosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring. | MOESIN crosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring.
Jankovics F, Sinka R, Lukácsovich T, Erdélyi M. | 01/21/2010 |
| Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. | Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila.
Médina E, Williams J, Klipfell E, Zarnescu D, Thomas CM, Le Bivic A., Free PMC Article | 01/21/2010 |