| The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling. | The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Li R, Guan Z, Bi S, Wang F, He L, Niu X, You Y, Liu Y, Ding Y, Siwko S, Wang N, Zhang Z, Jin Y, Luo J., Free PMC Article | 04/16/2022 |
| The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson's Disease. | The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson's Disease.
Haque ME, Azam S, Akther M, Cho DY, Kim IS, Choi DK., Free PMC Article | 06/12/2021 |
| Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4. | CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S., Free PMC Article | 02/16/2019 |
| GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues. | GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.
Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O'Rourke D, Yang LV., Free PMC Article | 12/22/2018 |
| GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. | GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP.
Dong B, Zhang X, Fan Y, Cao S, Zhang X. | 12/9/2017 |
| Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin-angiotensin system. | Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.
Sun X, Tommasi E, Molina D, Sah R, Brosnihan KB, Diz D, Petrovic S., Free PMC Article | 07/8/2017 |
| knockdown of a proton-sensing G protein-coupled receptor GPR4 markedly reduced CHOP expression and endothelial cell apoptosis after hypoxia exposure. | Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.
Dong B, Zhou H, Han C, Yao J, Xu L, Zhang M, Fu Y, Xia Q., Free PMC Article | 12/26/2015 |
| required for maintenance of normal acid-base homeostasis | Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.
Sun X, Stephens L, DuBose TD Jr, Petrovic S. | 10/3/2015 |
| The results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling. | GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway.
Justus CR, Yang LV. | 08/15/2015 |
| The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity. | PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA., Free PMC Article | 07/25/2015 |
| These results suggested that, at least in part, RANKL expression by osteoblasts in an acidic environment was mediated by cAMP/PKA signaling resulting from GPR4 activation. | Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.
Okito A, Nakahama K, Akiyama M, Ono T, Morita I. | 05/2/2015 |
| GPR4 modulates glucose homeostasis by increasing insulin sensitivity. | The proton-activated receptor GPR4 modulates glucose homeostasis by increasing insulin sensitivity.
Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA. | 08/16/2014 |
| Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor. | Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.
Wyder L, Suply T, Ricoux B, Billy E, Schnell C, Baumgarten BU, Maira SM, Koelbing C, Ferretti M, Kinzel B, Müller M, Seuwen K, Ludwig MG. | 03/10/2012 |
| findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase is at least partly responsible for this phenotype | Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor.
Castellone RD, Leffler NR, Dong L, Yang LV. | 12/3/2011 |
| pH sensor with an important role in regulating acid secretion in the kidney collecting duct | Deletion of the pH sensor GPR4 decreases renal acid excretion.
Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB, Petrovic S., Free PMC Article | 10/30/2010 |
| These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing. | Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.
Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON., Free PMC Article | 01/21/2010 |