| RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator. | RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator.
Lee FFY, Harris C, Alper S., | 05/14/2024 |
| Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression. | Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression.
Wu X, Cao C, Li Z, Xie Y, Zhang S, Sun W, Guo J. | 04/30/2024 |
| ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. | ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells.
Liu W, Fang S, Yang Z, Ma J, Tan Y, Chen Y, Zhang K, Liu K, Gu W. | 02/1/2024 |
| Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties. | Alternative Splicing Factor Heterogeneous Nuclear Ribonucleoprotein U as a Promising Biomarker for Gastric Cancer Risk and Prognosis with Tumor-Promoting Properties.
Dong YY, Wang MY, Jing JJ, Wu YJ, Li H, Yuan Y, Sun LP. | 01/6/2024 |
| RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor. | RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor.
Wang X, Xu J, Li Q, Zhang Y, Lin Z, Zhai X, Wang F, Huang J, Gao Q, Wen J, Li L, Feng Y, Luo H, Li Q, Liu X, Li J, Zhao F, Zhang L, Niu T, Sun C, Zheng Y. | 12/6/2023 |
| circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression. | circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression.
Li H, Jiao W, Song J, Wang J, Chen G, Li D, Wang X, Bao B, Du X, Cheng Y, Yang C, Tong Q, Zheng L., Free PMC Article | 11/27/2023 |
| Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis. | Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis.
Mastropasqua F, Oksanen M, Soldini C, Alatar S, Arora A, Ballarino R, Molinari M, Agostini F, Poulet A, Watts M, Rabkina I, Becker M, Li D, Anderlid BM, Isaksson J, Lundin Remnelius K, Moslem M, Jacob Y, Falk A, Crosetto N, Bienko M, Santini E, Borgkvist A, Bölte S, Tammimies K., Free PMC Article | 10/11/2023 |
| Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome. | Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome.
Lee S, Ochoa E, Badura-Stronka M, Donnelly D, Lederer D, Lynch SA, Gardham A, Morton J, Stewart H, Docquier F, Rodger F, Martin E, Toribio A, Maher ER, Balasubramanian M., Free PMC Article | 09/8/2023 |
| piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. | piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.
Zhang W, Zheng Z, Wang K, Mao W, Li X, Wang G, Zhang Y, Huang J, Zhang N, Wu P, Liu J, Zhang H, Che J, Peng B, Zheng J, Li W, Yao X., Free PMC Article | 07/6/2023 |
| [Clinical significance and pathogenesis analysis of heterogeneous nuclear ribonucleoprotein U in acute myeloid leukemia]. | [Clinical significance and pathogenesis analysis of heterogeneous nuclear ribonucleoprotein U in acute myeloid leukemia].
Xu CL, Chen Y, Zhu TT, Sun ZJ, Chu JH., Free PMC Article | 02/4/2023 |
| HNRNPU promotes the progression of triple-negative breast cancer via RNA transcription and alternative splicing mechanisms. | HNRNPU promotes the progression of triple-negative breast cancer via RNA transcription and alternative splicing mechanisms.
Han BY, Liu Z, Hu X, Ling H., Free PMC Article | 11/19/2022 |
| Heterogeneous nuclear ribonucleoprotein U-actin complex derived from extracellular vesicles facilitates proliferation and migration of human coronary artery endothelial cells by promoting RNA polymerase II transcription. | Heterogeneous nuclear ribonucleoprotein U-actin complex derived from extracellular vesicles facilitates proliferation and migration of human coronary artery endothelial cells by promoting RNA polymerase II transcription.
Wang H, Liu H, Zhao X, Chen X., Free PMC Article | 05/14/2022 |
| De novo frameshift variants of HNRNPU in patients with early infantile epileptic encephalopathy: Two case reports and literature review. | De novo frameshift variants of HNRNPU in patients with early infantile epileptic encephalopathy: Two case reports and literature review.
Song Z, Zhang Y, Yang C, Yi Z, Li F, Xue J, Yang X, Li B. | 04/30/2022 |
| hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. | hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S., Free PMC Article | 02/12/2022 |
| HNRNPU promotes the progression of hepatocellular carcinoma by enhancing CDK2 transcription. | HNRNPU promotes the progression of hepatocellular carcinoma by enhancing CDK2 transcription.
Liang Y, Fan Y, Liu Y, Fan H. | 12/11/2021 |
| HNRNPU-AS1 Regulates Cell Proliferation and Apoptosis via the MicroRNA 205-5p/AXIN2 Axis and Wnt/beta-Catenin Signaling Pathway in Cervical Cancer. | HNRNPU-AS1 Regulates Cell Proliferation and Apoptosis via the MicroRNA 205-5p/AXIN2 Axis and Wnt/β-Catenin Signaling Pathway in Cervical Cancer.
Niu Z, Wang F, Lv S, Lv Y, Liu M, Fu L, Yao Y, Wang L, Lin W, Yuan F., Free PMC Article | 10/16/2021 |
| The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma. | The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma.
Zhang B, Wang HY, Zhao DX, Wang DX, Zeng Q, Xi JF, Nan X, He LJ, Zhou JN, Pei XT, Yue W. | 07/10/2021 |
| Clinical findings of 21 previously unreported probands with HNRNPU-related syndrome and comprehensive literature review. | Clinical findings of 21 previously unreported probands with HNRNPU-related syndrome and comprehensive literature review.
Durkin A, Albaba S, Fry AE, Morton JE, Douglas A, Beleza A, Williams D, Volker-Touw CML, Lynch SA, Canham N, Clowes V, Straub V, Lachlan K, Gibbon F, El Gamal M, Varghese V, Parker MJ, Newbury-Ecob R, Turnpenny PD, Gardham A, Ghali N, Balasubramanian M. | 03/13/2021 |
| HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells. | HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.
Nishikawa T, Kuwano Y, Takahara Y, Nishida K, Rokutan K., Free PMC Article | 10/24/2020 |
| our findings uncover an oncogenic role of DIS3L2, in which it promotes liver cancer progression through a previously unappreciated mechanism of regulating hnRNP U-mediated alterative splicing | DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.
Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD, Zhang H. | 05/30/2020 |
| It aims to discuss the role of HNRNPU in maintaining the 3D chromatin architecture, as well as the recent development and human diseases involved in this nuclear matrix (NM)-associated protein. | The role of nuclear matrix protein HNRNPU in maintaining the architecture of 3D genome.
Zhang L, Song D, Zhu B, Wang X. | 04/18/2020 |
| This series demonstrates common phenotypic features, including emerging dysmorphism, associated with heterozygous HNRNPU mutations. This allows us to define a novel neurodevelopmental syndrome, with a likely mechanism of haploinsufficiency | De novo mutations in HNRNPU result in a neurodevelopmental syndrome.
Yates TM, Vasudevan PC, Chandler KE, Donnelly DE, Stark Z, Sadedin S, Willoughby J, Broad Center for Mendelian Genomics, DDD study, Balasubramanian M., Free PMC Article | 06/9/2018 |
| SAF-A, in concert with Ku, temporally regulates base damage repair in irradiated cell genome. | Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions.
Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S., Free PMC Article | 02/17/2018 |
| HNRPU deletion is associated with neurodevelopmental disorders. | Clinical and molecular characterization of de novo loss of function variants in HNRNPU.
Leduc MS, Chao HT, Qu C, Walkiewicz M, Xiao R, Magoulas P, Pan S, Beuten J, He W, Bernstein JA, Schaaf CP, Scaglia F, Eng CM, Yang Y. | 02/10/2018 |
| We broaden the clinical and mutational HNRNPU-associated spectrum, and demonstrate that heterozygous HNRNPU variants cause epilepsy, severe intellectual disability with striking speech impairment and variable central nervous system, cardiac, and renal anomalies. | Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability.
Bramswig NC, Lüdecke HJ, Hamdan FF, Altmüller J, Beleggia F, Elcioglu NH, Freyer C, Gerkes EH, Demirkol YK, Knupp KG, Kuechler A, Li Y, Lowenstein DH, Michaud JL, Park K, Stegmann APA, Veenstra-Knol HE, Wieland T, Wollnik B, Engels H, Strom TM, Kleefstra T, Wieczorek D. | 08/19/2017 |