| Tight control of the APP-Mint1 interaction in regulating amyloid production. | Tight control of the APP-Mint1 interaction in regulating amyloid production.
Henry SM, Kistler SA, Lagani GD, Bartling CRO, Özcelik D, Sereikaite V, Strømgaard K, Beffert U, Ho A., Free PMC Article | 08/30/2023 |
| Structural Basis for the High-Affinity Interaction between CASK and Mint1. | Structural Basis for the High-Affinity Interaction between CASK and Mint1.
Wu X, Cai Q, Chen Y, Zhu S, Mi J, Wang J, Zhang M. | 05/1/2021 |
| X11 and X11L regulate the glutamate receptor micro-localization to the extrasynaptic region | X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors.
Motodate R, Saito H, Sobu Y, Hata S, Saito Y, Nakaya T, Suzuki T. | 11/2/2019 |
| Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues. | Expression and localization of X11 family proteins in neurons.
Motodate R, Saito Y, Hata S, Suzuki T. | 07/22/2017 |
| Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect. | The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.
O'Sullivan J, Comerford E, Rachidi W, Scott M, Hooper NM, McMahon HE. | 12/19/2015 |
| Mint1 826 bridges APP to the small GTPase | A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.
Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A., Free PMC Article | 01/11/2014 |
| Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). | A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Li Z, Mulligan MK, Wang X, Miles MF, Lu L, Williams RW., Free PMC Article | 09/10/2010 |
| These results suggest that the three Mint/X11 proteins regulate Abeta production by a novel mechanism that may have implications for therapeutic approaches to altering APP cleavage in Alzheimer's disease. | Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
Ho A, Liu X, Südhof TC., Free PMC Article | 01/21/2010 |
| X11s associate primarily with APP molecules that are outside of DRM, that the dissociation of APP-X11/X11L complexes leads to entry of APP into DRM, and that cleavage of uncomplexed APP by BACE within DRM | X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T., Free PMC Article | 01/21/2010 |
| Reports have demonstrated that KIF17-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser 1029 of KIF17 was phosphorylated. | Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release.
Guillaud L, Wong R, Hirokawa N. | 01/21/2010 |
| Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin action. | Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity.
Verlaeten O, Casery C, Cavagna S, Naville D, Giraudon P, Belin MF, Begeot M, Bernard A. | 01/21/2010 |
| Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival. | Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC., Free PMC Article | 01/21/2010 |
| Our data support a function for both GSK3 and CDK5 in amyloid precursor protein processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease. | Divergent roles of GSK3 and CDK5 in APP processing.
Ryder J, Su Y, Liu F, Li B, Zhou Y, Ni B. | 01/21/2010 |