| ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer. | ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer.
Hong HJ, Shao Y, Zhang S, Yang G, Jia H, Yang X, Huang L, Li S, Aikemu B, Zhang L, Ma J, Zang L, Sun J, Zheng M., Free PMC Article | 01/14/2023 |
| Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals. | Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals.
Chan GCW, Zhi H, Hicks PJ, Freedman BI, Tang SCW. | 04/16/2022 |
| Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis. | Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.
Dong Z, Lei X, Kujawa SA, Bolu N, Zhao H, Wang C., Free PMC Article | 10/16/2021 |
| Faster lipid beta-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1alpha in human podocytes. | Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.
Wang Q, Zhao B, Zhang J, Sun J, Wang S, Zhang X, Xu Y, Wang R. | 09/4/2021 |
| Results identified ACC2 amino acid mutations affecting specific inhibition of the isozyme by compound CD-017-0191. They form two clusters separated by 60-90 A: one located in the vicinity of the BC active site and the other one in the vicinity of the ACC1 phosphorylation sites in the central domain, suggesting a contribution of the interface of two ACC dimers in the polymer to the inhibitor binding site. | Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.
Jang S, Gornicki P, Marjanovic J, Bass E, P Iurcotta T, Rodriguez P, Austin J 2nd, Haselkorn R. | 05/11/2019 |
| Targeted analysis of DNA methylation array revealed the mesenchymal stem cells in infants born to obese mothers had hypermethylation in genes regulating Fatty Acid Oxidation (PRKAG2, ACC2, CPT1A, SDHC) and corresponding lower mRNA content of these genes. Moreover, mesenchymal stem cells methylation was positively correlated with infant adiposity. | Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.
Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE., Free PMC Article | 01/19/2019 |
| ACC2 gene (ACACB) expression was decreased by 25% in HCC tissue compared to non-cancerous liver tissue. | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nelson ME, Lahiri S, Chow JD, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, Hoehn KL., Free PMC Article | 11/17/2018 |
| of ACCs decreased polyunsaturated fatty acid (PUFA) concentrations in liver due to reduced malonyl-CoA, which is required for elongation of essential fatty acids. | Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD., Free PMC Article | 04/21/2018 |
| PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2. | PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC., Free PMC Article | 09/9/2017 |
| Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells | Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.
Jones JE, Esler WP, Patel R, Lanba A, Vera NB, Pfefferkorn JA, Vernochet C., Free PMC Article | 08/5/2017 |
| Cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent. | Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.
Luo J, Hong Y, Lu Y, Qiu S, Chaganty BK, Zhang L, Wang X, Li Q, Fan Z., Free PMC Article | 08/5/2017 |
| A significant association exists of ACACB gene polymorphism and diabetic nephropathy among Caucasian patients with diabetes. | The ACACB gene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis.
An L, Jiang H, Tang RN. | 06/11/2016 |
| Our meta-analysis supports that the apolipoprotein E epsilon2 allele and acetyl-CoA carboxylase beta rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes. | The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis.
Li T, Shi Y, Yin J, Qin Q, Wei S, Nie S, Liu L. | 09/26/2015 |
| The knockdown of ACC2 reduced palmitic acid -induced autophagy and thus protects the cells from palmitic acid - induced lipotoxicity with attenuated lipid accumulation and rescued cell viability. | Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy.
Xin W, Zhao X, Liu L, Xu Y, Li Z, Chen L, Wang X, Yi F, Wan Q. | 09/12/2015 |
| These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to diabetic nephropathy. | An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
Ma L, Murea M, Snipes JA, Marinelarena A, Krüger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA, Shores NJ, Rudel LL, Blüher M, Stumvoll M, Bowden DW, Maeda S, Parks JS, Kovacs P, Hanson RL, Baier LJ, Elbein SC, Freedman BI., Free PMC Article | 09/7/2013 |
| TT genotypes of ACACB gene (rs2268388) and CC genotype of AGTR1 gene (rs5186) confers the risk of diabetic nephropathy in Asian Indian patients with T2DM. | ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes.
Shah VN, Cheema BS, Sharma R, Khullar M, Kohli HS, Ahluwalia TS, Mohan V, Bhansali A. | 05/18/2013 |
| Its involvement in the development of diabetic nephropathy is explained by the promotion of the so-called micro-inflammation associated with the diabetic state. | [Genetic study for diabetic microvascular complications--recent advances and future perspectives].
Maeda S. | 03/2/2013 |
| A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population. | A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population.
Kotani K, Fujiwara S, Tsuzaki K, Sano Y, Sakane N. | 05/12/2012 |
| In conclusion, common polymorphisms of ACACB gene are associated with obesity and, independently, with type 2 diabetes in postmenopausal women | Association of ACACB polymorphisms with obesity and diabetes.
Riancho JA, Vázquez L, García-Pérez MA, Sainz J, Olmos JM, Hernández JL, Pérez-López J, Amado JA, Zarrabeitia MT, Cano A, Rodríguez-Rey JC. | 03/17/2012 |
| Common variants within the ACACB locus appear to regulate adipose gene expression | The effect of ACACB cis-variants on gene expression and metabolic traits.
Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW, Kovacs P, Antinozzi PA, Stumvoll M, Parks JS, Elbein SC, Freedman BI., Free PMC Article | 02/25/2012 |
| Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion. | Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
Rajamohan F, Marr E, Reyes AR, Landro JA, Anderson MD, Corbett JW, Dirico KJ, Harwood JH, Tu M, Vajdos FF., Free PMC Article | 01/28/2012 |
| The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. | The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
Tang SC, Leung VT, Chan LY, Wong SS, Chu DW, Leung JC, Ho YW, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI., Free PMC Article | 04/23/2011 |
| Acetyl-CoA carboxylase beta (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. | ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat.
Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM., Free PMC Articles: PMC2975722, PMC2975722 | 02/26/2011 |
| The -368 C/T single-nucleotide polymorphism in ACACB P-II binds HepG2 nuclear proteins that affect promoter activity in an allele-specific fashion. | Functional single-nucleotide polymorphism in acetyl-CoA carboxylase ACACB gene promoter.
Lee AK, Kyriakou T, Weston AJ, O'Dell SD. | 01/15/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat.
Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM., Free PMC Articles: PMC2975722, PMC2975722 | 12/5/2010 |