| Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5). | Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5).
Wei D, Zeng J, Rong F, Xu Y, Wei R, Zou C., Free PMC Article | 04/16/2022 |
| HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway. | HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway.
Zhang J, Zhang S, Li X, Zhang F, Zhao L. | 01/15/2022 |
| CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3. | CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3.
Feng W, Huang W, Chen J, Qiao C, Liu D, Ji X, Xie M, Zhang T, Wang Y, Sun M, Tian D, Fan D, Nie Y, Wu K, Xia L., Free PMC Article | 07/31/2021 |
| Homeobox B5 suppression attenuates proliferation and elevates apoptosis in hepatoma cell lines through ERK/MDM2 signalling. | Homeobox B5 suppression attenuates proliferation and elevates apoptosis in hepatoma cell lines through ERK/MDM2 signalling.
Su B, Zhang X, Luo G. | 07/17/2021 |
| HOXB5 Confers Tamoxifen Resistance in Breast Cancer Cells and Promotes Tumor Aggression and Progression. | HOXB5 Confers Tamoxifen Resistance in Breast Cancer Cells and Promotes Tumor Aggression and Progression.
Kim CY, Kim YC, Oh JH, Kim MH. | 07/10/2021 |
| HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3beta/beta-catenin pathway. | HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3β/β-catenin pathway.
Gao Y, Fei X, Kong L, Tan X. | 06/19/2021 |
| HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway. | HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway.
Li ZX, Wu G, Jiang WJ, Li J, Wang YY, Ju XM, Yin YT., Free PMC Article | 01/30/2021 |
| HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/beta-catenin signaling axis. | HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin signaling axis.
Lee K, Chang JW, Oh C, Liu L, Jung SN, Won HR, Kim YI, Rha KS, Koo BS. | 12/19/2020 |
| In breast cancer cells, HOXB5 regulates EGFR expression at the transcriptional level by directly binding to its promoter region and promotes phosphorylation of EGFR as well as its downstream effectors | Transcriptional activation of EGFR by HOXB5 and its role in breast cancer cell invasion.
Lee JY, Kim JM, Jeong DS, Kim MH. | 01/19/2019 |
| for the first time we have shown that knockdown of HOXB5 significantly inhibited non-small cell lung cancer cell proliferation, invasion, metastasis, and epithelial-mesenchymal transformation, partly through the Wnt/beta-catenin signaling pathway | Knockdown of Homeobox B5 (HOXB5) Inhibits Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells Through Inactivation of the Wnt/β-Catenin Pathway.
Zhang B, Li N, Zhang H., Free PMC Article | 08/18/2018 |
| Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. | miR-455-3p serves as prognostic factor and regulates the proliferation and migration of non-small cell lung cancer through targeting HOXB5.
Gao X, Zhao H, Diao C, Wang X, Xie Y, Liu Y, Han J, Zhang M. | 12/30/2017 |
| HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer. | HOXB5 Promotes the Proliferation and Invasion of Breast Cancer Cells.
Lee JY, Hur H, Yun HJ, Kim Y, Yang S, Kim SI, Kim MH., Free PMC Article | 04/16/2016 |
| HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis. | HOXB5 induces invasion and migration through direct transcriptional up-regulation of β-catenin in human gastric carcinoma.
Hong CS, Jeong O, Piao Z, Guo C, Jung MR, Choi C, Park YK. | 03/19/2016 |
| Roles of Hoxb5 in the development of vagal and trunk neural crest cells. | Roles of Hoxb5 in the development of vagal and trunk neural crest cells.
Kam MK, Lui VC. | 11/21/2015 |
| Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. | The transcription factor HoxB5 stimulates vascular remodelling in a cytokine-dependent manner.
Fessner A, Esser JS, Bluhm F, Grundmann S, Zhou Q, Patterson C, Bode C, Moser M. | 10/4/2014 |
| HOXB5 and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions. | HOXB8 expression in ovarian serous carcinoma effusions is associated with shorter survival.
Stavnes HT, Holth A, Don T, Kærn J, Vaksman O, Reich R, Trope' CG, Davidson B. | 06/15/2013 |
| The findings for HOXB5 and PHOX2B provide supportive evidence that genes regulating ENCC proliferation, migration and differentiation could be risk factors for Hirschsprung's disease | Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation.
Carter TC, Kay DM, Browne ML, Liu A, Romitti PA, Kuehn D, Conley MR, Caggana M, Druschel CM, Brody LC, Mills JL., Free PMC Article | 04/6/2013 |
| A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. | A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer.
Luo J, Cai Q, Wang W, Huang H, Zeng H, He W, Deng W, Yu H, Chan E, Ng CF, Huang J, Lin T., Free PMC Article | 12/8/2012 |
| HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. | Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.
di Pietro M, Lao-Sirieix P, Boyle S, Cassidy A, Castillo D, Saadi A, Eskeland R, Fitzgerald RC., Free PMC Article | 09/1/2012 |
| Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity. | A genome-wide association meta-analysis identifies new childhood obesity loci.
Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PM, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM, St Pourcain B, Berry DJ, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, van der Valk RJ, de Jongste JC, Postma DS, Boomsma DI, Gauderman WJ, Hassanein MT, Lindgren CM, Mägi R, Boreham CA, Neville CE, Moreno LA, Elliott P, Pouta A, Hartikainen AL, Li M, Raitakari O, Lehtimäki T, Eriksson JG, Palotie A, Dallongeville J, Das S, Deloukas P, McMahon G, Ring SM, Kemp JP, Buxton JL, Blakemore AI, Bustamante M, Guxens M, Hirschhorn JN, Gillman MW, Kreiner-Møller E, Bisgaard H, Gilliland FD, Heinrich J, Wheeler E, Barroso I, O'Rahilly S, Meirhaeghe A, Sørensen TI, Power C, Palmer LJ, Hinney A, Widen E, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF, Early Growth Genetics Consortium., Free PMC Article | 07/7/2012 |
| results support that expression of HOX genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes. | HOXB5 expression in oral squamous cell carcinoma.
Tucci R, Campos MS, Matizonkas-Antonio LF, Durazzo M, Pinto Junior Ddos S, Nunes FD., Free PMC Article | 10/29/2011 |
| Data show that human HOXB5 binds to the promoter region 5' upstream of the binding site of NKX2-1 and regulates RET expression. | HOXB5 cooperates with NKX2-1 in the transcription of human RET.
Zhu J, Garcia-Barcelo MM, Tam PK, Lui VC., Free PMC Article | 10/22/2011 |
| DNA hypermethylation of tumour suppressor genes seems to play an important role in ovarian carcinogenesis and HOXA9, HOXB5, SCGB3A1, and CRABP1 are identified as novel hypermethylated target genes in this tumour type | DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.
Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE., Free PMC Article | 01/21/2010 |
| HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors | HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.
Wu Y, Moser M, Bautch VL, Patterson C., Free PMC Article | 01/21/2010 |
| The expression pattern of HOXB5 correlated with the migration and differentiation of neural crest cells. | HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts.
Fu M, Lui VC, Sham MH, Cheung AN, Tam PK. | 01/21/2010 |