| The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms. | The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms.
Hidalgo S, Campusano JM, Hodge JJL. | 01/22/2022 |
| Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA. | Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
Krick N, Ryglewski S, Pichler A, Bikbaev A, Götz T, Kobler O, Heine M, Thomas U, Duch C., Free PMC Article | 12/4/2021 |
| Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior. | Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.
Leinwand SG, Scott K., Free PMC Article | 06/26/2021 |
| Deletion of exon 7 caused a decrease in cacophony protein expression but not total transcript levels, caused reduced locomotory activity in adults, and locomotion defects in third instar larvae. | Deletion of a specific exon in the voltage-gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae.
Lembke KM, Law AD, Ahrar J, Morton DB., Free PMC Article | 03/28/2020 |
| Study finds that the abundance of endogenous Cac is modulated during presynaptic homeostatic potentiation, but does not change during presynaptic homeostatic depression. | Endogenous Tagging Reveals Differential Regulation of Ca(2+) Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.
Gratz SJ, Goel P, Bruckner JJ, Hernandez RX, Khateeb K, Macleod GT, Dickman D, O'Connor-Giles KM., Free PMC Article | 03/21/2020 |
| Strikingly the absence of any of DLG proteins at the presynaptic terminal disrupts the clustering and localization of the calcium channel DmCa1A subunit (Cacophony), decreases the action potential-evoked release probability and alters short-term plasticity. | Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels.
Astorga C, Jorquera RA, Ramírez M, Kohler A, López E, Delgado R, Córdova A, Olguín P, Sierralta J., Free PMC Article | 05/19/2018 |
| Motor defects in TDP-43 mutants can be rescued by expression of cacophony in motor neurons and by expression in two pairs of neurons in the brain. | Restoration of Motor Defects Caused by Loss of Drosophila TDP-43 by Expression of the Voltage-Gated Calcium Channel, Cacophony, in Central Neurons.
Lembke KM, Scudder C, Morton DB., Free PMC Article | 10/14/2017 |
| the novel R1673P allele of CACNA1A produces neurodegenerative phenotypes in flies and human, likely due to a toxic gain of function | Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially.
Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF, Members of the UDN., Free PMC Article | 08/26/2017 |
| cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel alpha1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants | Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila.
Saras A, Tanouye MA., Free PMC Article | 05/14/2016 |
| Cac regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. | A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C., Free PMC Article | 01/23/2016 |
| Homeostatic depression is achieved by decreased presynaptic Cav2.1 calcium channel abundance and calcium influx. | Homeostatic synaptic depression is achieved through a regulated decrease in presynaptic calcium channel abundance.
Gaviño MA, Ford KJ, Archila S, Davis GW., Free PMC Article | 01/16/2016 |
| Dopaminergic neurons with mutant Ca2+ channel cacophony are inherently resistant to MPP+-induced neurodegeneration. | Role of Drosophila calcium channel cacophony in dopaminergic neurodegeneration and neuroprotection.
Wiemerslage L, Lee D. | 06/27/2015 |
| cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications | Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.
Lee J, Ueda A, Wu CF., Free PMC Article | 08/9/2014 |
| Vesicle exocytosis depends on cacophony, TRP and TRPL. | TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila.
Astorga G, Härtel S, Sanhueza M, Bacigalupo J., Free PMC Article | 02/9/2013 |
| Homeostatic increase in Ca(2+) influx and release is blocked by a point mutation in the presynaptic CaV2.1 channel. | Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.
Müller M, Davis GW., Free PMC Article | 10/27/2012 |
| cac encoded Ca(v)2-type calcium channels regulate action potential (AP)-independent release of neurotransmitter at excitatory cholinergic synapses | Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain.
Gu H, Jiang SA, Campusano JM, Iniguez J, Su H, Hoang AA, Lavian M, Sun X, O'Dowd DK., Free PMC Article | 01/21/2010 |
| Neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta Ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses. | straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
Ly CV, Yao CK, Verstreken P, Ohyama T, Bellen HJ., Free PMC Article | 01/21/2010 |
| These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system. | Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.
Frank CA, Kennedy MJ, Goold CP, Marek KW, Davis GW., Free PMC Article | 01/21/2010 |
| Data show that the Drosophila cacophony ts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation | The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.
Macleod GT, Chen L, Karunanithi S, Peloquin JB, Atwood HL, McRory JE, Zamponi GW, Charlton MP. | 01/21/2010 |
| role of mutation in courtship and other behaviors | Courtship and other behaviors affected by a heat-sensitive, molecularly novel mutation in the cacophony calcium-channel gene of Drosophila.
Chan B, Villella A, Funes P, Hall JC., Free PMC Article | 01/21/2010 |
| Localization of cacophony on presynaptic terminals at neuromuscular synapses. | Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila.
Kawasaki F, Zou B, Xu X, Ordway RW., Free PMC Article | 01/21/2010 |
| Cacophony protein plays a key role in developmental regulation of Drosophila neuronal excitability. | Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation.
Peng IF, Wu CF., Free PMC Article | 01/21/2010 |
| Dmca1A is an allele of the N-type calcium channel locus that caused synaptic undergrowth | Presynaptic N-type calcium channels regulate synaptic growth.
Rieckhof GE, Yoshihara M, Guan Z, Littleton JT. | 01/21/2010 |