| CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1. | CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A, Fang Y., Free PMC Article | 12/25/2021 |
| Here, the authors show that the Casein Kinase 1 (CKI) family is required for Expanded phosphorylation. CKI expression promotes Expanded phosphorylation and interaction with Slimb/beta-TrCP. | Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.
Fulford AD, Holder MV, Frith D, Snijders AP, Tapon N, Ribeiro PS., Free PMC Article | 02/15/2020 |
| Ck1alpha interacts with DOUBLETIME to achieve the overall function of speeding up PERIOD metabolism and to ensure proper time-keeping. | CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock.
Lam VH, Li YH, Liu X, Murphy KA, Diehl JS, Kwok RS, Chiu JC., Free PMC Article | 10/12/2019 |
| glucose regulatory role | Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.
Ugrankar R, Berglund E, Akdemir F, Tran C, Kim MS, Noh J, Schneider R, Ebert B, Graff JM., Free PMC Article | 04/16/2016 |
| we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes. | Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.
Nguyen HQ, Nye J, Buster DW, Klebba JE, Rogers GC, Bosco G., Free PMC Article | 07/25/2015 |
| Expected genes in the Scar-Arp2/3 actin nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature. | A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis.
D'Ambrosio MV, Vale RD., Free PMC Article | 12/11/2010 |
| Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo. | Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases.
Galletti M, Riccardo S, Parisi F, Lora C, Saqcena MK, Rivas L, Wong B, Serra A, Serras F, Grifoni D, Pelicci P, Jiang J, Bellosta P., Free PMC Article | 01/21/2010 |
| Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway. | Regulation of wingless signaling by the CKI family in Drosophila limb development.
Zhang L, Jia J, Wang B, Amanai K, Wharton KA Jr, Jiang J., Free PMC Article | 01/21/2010 |
| CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser and Thr residues in the N-terminus and targeting it for degradation. | Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.
Yanagawa S, Matsuda Y, Lee JS, Matsubayashi H, Sese S, Kadowaki T, Ishimoto A., Free PMC Article | 01/21/2010 |
| 2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways | Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.
Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA. | 01/21/2010 |
| expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm | Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.
Preuss F, Fan JY, Kalive M, Bao S, Schuenemann E, Bjes ES, Price JL., Free PMC Article | 01/21/2010 |
| doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity | The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity.
Nawathean P, Rosbash M. | 01/21/2010 |