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    HOXC10 homeobox C10 [ Homo sapiens (human) ]

    Gene ID: 3226, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-beta/Smad signaling pathway.

    HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway.
    Zhou X, Lin S.

    11/4/2024
    The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.

    The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer.
    Li K, Yang B, Du Y, Ding Y, Shen S, Sun Z, Liu Y, Wang Y, Cao S, Ren W, Wang X, Li M, Zhang Y, Wu J, Zheng W, Yan W, Li L., Free PMC Article

    10/4/2024
    Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma.

    Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma.
    Tan X, Li Z, Xie H, Chen J, Xiao J, Zhi Y, Mo H, Huang Y, Liu A., Free PMC Article

    01/29/2024
    m[6]A-modified HOXC10 promotes HNSCC progression via co-activation of ADAM17/EGFR and Wnt/beta-catenin signaling.

    m(6)A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling.
    Zhou Y, Huang Q, Wu C, Xu Y, Guo Y, Yuan X, Xu C, Zhou L., Free PMC Article

    01/10/2024
    HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21.

    HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21.
    Lin ZH, He JM, Lai SC, Ding N, Jiang Y, He XK, Liu XS, Huang ZH.

    01/11/2023
    [The effect of HOXC10 gene on biological behaviors of glioma cells and mechanism in tumor microenvironment].

    [The effect of HOXC10 gene on biological behaviors of glioma cells and mechanism in tumor microenvironment].
    Jiang WY, Lei QY, Liu SS, Yang L, Yang B, Zhang Y.

    04/2/2022
    HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.

    HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma.
    Yu M, Yu S, Zhou W, Yi B, Liu Y.

    03/19/2022
    Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway.

    Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway.
    Shen J, Wang M, Li F, Yan H, Zhou J., Free PMC Article

    02/26/2022
    Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.

    Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.
    Chen Z, Wu J, Liu B, Zhang G, Wang Z, Zhang L, Wang K, Fan Z, Zhu P.

    02/12/2022
    Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells.

    Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells.
    Xie Y, Chen R, Yan L, Jia Z, Liang G, Wang Q., Free PMC Article

    01/29/2022
    The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3'-UTR of HOXC10 mRNA.

    The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3'-UTR of HOXC10 mRNA.
    Priyanka P, Sharma M, Das S, Saxena S., Free PMC Article

    12/4/2021
    MiR-129-5p Restrains Apatinib Resistance in Human Gastric Cancer Cells Via Downregulating HOXC10.

    MiR-129-5p Restrains Apatinib Resistance in Human Gastric Cancer Cells Via Downregulating HOXC10.
    Yu J, Zhang X, Ma Y, Li Z, Tao R, Chen W, Xiong S, Han X.

    10/9/2021
    Interleukin 1beta-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.

    Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.
    Dang Y, Chen J, Feng W, Qiao C, Han W, Nie Y, Wu K, Fan D, Xia L., Free PMC Article

    05/22/2021
    HOXC10 promotes cell migration, invasion, and tumor growth in gastric carcinoma cells through upregulating proinflammatory cytokines.

    HOXC10 promotes cell migration, invasion, and tumor growth in gastric carcinoma cells through upregulating proinflammatory cytokines.
    Li J, Tong G, Huang C, Luo Y, Wang S, Zhang Y, Cheng B, Zhang Z, Wu X, Liu Q, Li M, Li L, Ni B.

    02/6/2021
    MircoRNA-129-5p suppresses the development of glioma by targeting HOXC10.

    MircoRNA-129-5p suppresses the development of glioma by targeting HOXC10.
    Liu J, Cheng C, Jiao J, Huang W, Huang J, Sun J, Shao J.

    01/16/2021
    MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression.

    MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression.
    He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S.

    01/16/2021
    HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis.

    HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis.
    Suo D, Wang Z, Li L, Chen Q, Zeng T, Liu R, Yun J, Guan XY, Li Y.

    12/5/2020
    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.

    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.
    Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski K., Free PMC Article

    11/21/2020
    Data showed that lncHOXC-AS3 was required for osteogenesis in BM-MSCs by enhancing HOXC10 expression.

    HOXC10 Regulates Osteogenesis of Mesenchymal Stromal Cells Through Interaction with Its Natural Antisense Transcript lncHOXC-AS3.
    Li B, Han H, Song S, Fan G, Xu H, Zhou W, Qiu Y, Qian C, Wang Y, Yuan Z, Gao Y, Zhang Y, Zhuang W.

    04/4/2020
    Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway

    Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway.
    Guan Y, He Y, Lv S, Hou X, Li L, Song J.

    03/28/2020
    HOXC10 expression is upregulated in gastric cancer through DNA demethylation, and HOXC10 overexpression increases proliferation and migration of gastric cancer cells.

    HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
    Kim J, Bae DH, Kim JH, Song KS, Kim YS, Kim SY., Free PMC Article

    12/28/2019
    Protein arginine methyltransferase 5 (PRMT5) and WD repeat domain 5 (WDR5), both of which regulate histone post-translational modifications, were required for HOXC10-mediated VEGFA upregulation. Importantly, a significant correlation between HOXC10 levels and VEGFA expression was observed in a cohort of human gliomas.

    Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression.
    Tan Z, Chen K, Wu W, Zhou Y, Zhu J, Wu G, Cao L, Zhang X, Guan H, Yang Y, Zhang W, Li J., Free PMC Article

    09/7/2019
    High HOXC10 expression is associated with Recurrence in Gastric Cancer.

    Homeobox C10 Influences on the Malignant Phenotype of Gastric Cancer Cell Lines and its Elevated Expression Positively Correlates with Recurrence and Poor Survival.
    Miwa T, Kanda M, Umeda S, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y.

    08/10/2019
    that HOXC10 decreased the MSC osteogenic differentiation potential

    Homeobox C10 inhibits the osteogenic differentiation potential of mesenchymal stem cells.
    Li G, Han N, Yang H, Wang L, Lin X, Diao S, Du J, Dong R, Wang S, Fan Z.

    08/3/2019
    Our study revealed a new mechanism mediated by CHD7 for its role in promoting HOXC10 expression and contribute to mammary oncogenesis.

    G-quadruplex structures at the promoter of HOXC10 regulate its expression.
    Zhang X, Zhao B, Yan T, Hao A, Gao Y, Li D, Sui G.

    06/1/2019
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