| The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons. | The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons.
Ravenscroft TA, Jacobs A, Gu M, Eberl DF, Bellen HJ., Free PMC Article | 07/5/2023 |
| Loss of paralytic (para), the sole gene that encodes Drosophila voltage-gated sodium channels, reduces neuroblast progeny cell number | Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.
Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN., Free PMC Article | 12/21/2019 |
| Study identified Shu, a Drosophila mutation causing severe behavioral defects, as a novel hypermorphic allele of the Nav channel gene para. Results suggest that the Shu Nav channels cause an increase in sodium currents, and that this defect is compensated by reduced para function, leading to a more balanced neuronal output. | Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic.
Kaas GA, Kasuya J, Lansdon P, Ueda A, Iyengar A, Wu CF, Kitamoto T., Free PMC Article | 11/4/2017 |
| analysis revealed that 2 variant-specific amino acid changes, I260T in the S4-S5 linker of domain I (ILS4-S5) and A1731V in the voltage sensor S4 of domain IV (IVS4), contribute to the persistent sodium current (INaP) | Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.
Gao R, Du Y, Wang L, Nomura Y, Satar G, Gordon D, Gurevitz M, Goldin AL, Dong K., Free PMC Article | 12/20/2014 |
| Trp404 and His405 as a putative point of Av3 interaction with DmNav1. | The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels.
Gur Barzilai M, Kahn R, Regev N, Gordon D, Moran Y, Gurevitz M. | 11/22/2014 |
| The para(bss1) has not responded to seizure suppressor mutations identified in screens based on the Drosophila mutants eas protein and sda protein. | Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies.
Howlett IC, Rusan ZM, Parker L, Tanouye MA., Free PMC Article | 03/22/2014 |
| results indicate that increased synaptic activity influences the decision to splice in exon L, which, in turn, may promote seizure. | Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
Lin WH, Günay C, Marley R, Prinz AA, Baines RA., Free PMC Article | 08/4/2012 |
| 3-dimensional structure modeling of ANEPII and site-4 of the insect sodium channel were carried out by homology modeling, and these models were used as the starting point for nanosecond-duration molecular dynamics simulations. | Study of the binding residues between ANEPII and insect sodium channel receptor.
Song YB, Ma L, Yang WY, Wang J, Cheng MS, Wu CF, Zhang JH. | 01/8/2011 |
| Drosomycin interacts with the voltage-gated sodium channel, DmNa(v)1. | Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel.
Cohen L, Moran Y, Sharon A, Segal D, Gordon D, Gurevitz M., Free PMC Article | 01/21/2010 |
| The structure of the scorpion alpha-toxin LqhalphaIT binding site in the para sodium channel of Drosophila melanogaster was characterized using NMR Spectroscopy. | NMR analysis of interaction of LqhalphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel.
Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. | 01/21/2010 |
| Chromosome fusions from patterns of polymorphism at the X-linked para gene were studied. | Inferences on the evolutionary history of the Drosophila americana polymorphic X/4 fusion from patterns of polymorphism at the X-linked paralytic and elav genes.
Vieira CP, Coelho PA, Vieira J., Free PMC Article | 01/21/2010 |