| The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission. | The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission.
Kim JH, Ki Y, Lee H, Hur MS, Baik B, Hur JH, Nam D, Lim C., Free PMC Article | 06/19/2021 |
| Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density. | Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density.
Lewin L, Nsasra E, Golbary E, Hadad U, Orr I, Yifrach O., Free PMC Article | 01/2/2021 |
| S4-S5 linker movement during activation and inactivation in voltage-gated K(+) channels. | S4-S5 linker movement during activation and inactivation in voltage-gated K(+) channels.
Kalstrup T, Blunck R., Free PMC Article | 09/22/2018 |
| Authors provide evidence that in the Drosophila Shaker voltage-gated K(+) channels the S3 domain acts as an extracellular hydrophobic 'stabilizer' for the S4 domain biasing the gating chemical equilibrium toward the open state. | Energetic role of the paddle motif in voltage gating of Shaker K(+) channels.
Xu Y, Ramu Y, Shin HG, Yamakaze J, Lu Z., Free PMC Article | 07/6/2013 |
| This study demonstrates that Shaker is not always a good model for Kv1 channels for ligand binding. | Why the Drosophila Shaker K+ channel is not a good model for ligand binding to voltage-gated Kv1 channels.
Mahdavi S, Kuyucak S. | 04/27/2013 |
| The xenon requirement in Drosophila melanogaster is not influenced by a single gene mutation at the shaker locus, whereas a reduced expression of a nonselective cation channel leads to an increased xenon requirement. | The shaker potassium channel is no target for xenon anesthesia in short-sleeping Drosophila melanogaster mutants.
Schaper C, Höcker J, Böhm R, Roeder T, Bein B., Free PMC Article | 11/3/2012 |
| Data show several strong Cysteine-Cadmium-Cysteine bridges in Shaker potassium channel. | Tracking a complete voltage-sensor cycle with metal-ion bridges.
Henrion U, Renhorn J, Börjesson SI, Nelson EM, Schwaiger CS, Bjelkmar P, Wallner B, Lindahl E, Elinder F., Free PMC Article | 08/25/2012 |
| Synaptic transmission at the larval neuromuscular junction and the transient Shaker potassium current IA in larval muscles have been characterized. | Modulation of the frequency response of Shaker potassium channels by the quiver peptide suggesting a novel extracellular interaction mechanism.
Wang JW, Wu CF., Free PMC Article | 01/29/2011 |
| synaptic strength and synaptic strength at neuromuscular junctions along the dorsal-ventral differentials at physiological Ca(2+) levels were not significantly altered in slowpoke (slo) and Shaker (Sh) mutants | Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in Drosophila.
Lee J, Ueda A, Wu CF., Free PMC Article | 01/21/2010 |
| allosteric communication across disparate regions of the channel protein and between evolved and regulated amino acid changes introduced by RNA editing. | Regulated RNA editing and functional epistasis in Shaker potassium channels.
Ingleby L, Maloney R, Jepson J, Horn R, Reenan R., Free PMC Article | 01/21/2010 |
| Shaker K+ channels contribute to the information capacity of Drosophila photoreceptors | The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors.
Niven JE, Vähäsöyrinki M, Kauranen M, Hardie RC, Juusola M, Weckström M. | 01/21/2010 |
| interaction of the voltage-dependent Shaker potassium channel with the channel-blocking toxin kappa-conotoxin-PVIIA | Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore.
Moran O. | 01/21/2010 |
| The Shaker voltage-gated potassium channel pore opens when the inner helix bends at a conserved glycine gating hinge. | Conserved gating hinge in ligand- and voltage-dependent K+ channels.
Magidovich E, Yifrach O. | 01/21/2010 |
| reduce the metabolic cost of neural information in Drosophila photoreceptors. | Shaker K(+)-channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors.
Niven JE, Vähäsöyrinki M, Juusola M., Free PMC Article | 01/21/2010 |
| ShB(delta)K wes activated by binding with toxin 6-bromo-2-mercaptotryptamine (BrMT). | Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway.
Sack JT, Aldrich RW., Free PMC Article | 01/21/2010 |
| Results suggest that the external TEA binding site is not within the membrane electric field and that the voltage dependence of TEA block in K+ solutions arises through a coupling with the movement of K+ ions through part of the membrane electric field. | External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter.
Thompson J, Begenisich T., Free PMC Article | 01/21/2010 |
| Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency; short-sleeping Shaker flies have a reduced lifespan | Reduced sleep in Drosophila Shaker mutants.
Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, Tononi G. | 01/21/2010 |
| Second-order kernels of Shaker potassium channel mutants lack a large, early amplification and demonstrate a novel role for Shaker K+ channels in amplifying and accelerating the voltage response of wild-type photoreceptors. | Shaker K+ channels contribute early nonlinear amplification to the light response in Drosophila photoreceptors.
Juusola M, Niven JE, French AS. | 01/21/2010 |
| observations highlight crucial control of nerve terminal excitability by Shaker & Shab channels to confer temporal patterns of synaptic transmission & suggest participation of these channels in activity-dependent synaptic plasticity | Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.
Ueda A, Wu CF., Free PMC Article | 01/21/2010 |
| These results suggest that cooperative insertion of the voltage-sensor transmembrane helices is a property common to K(v) channels and that the degree of cooperativity depends on a balance between electrostatic and hydrophobic forces. | Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain.
Zhang L, Sato Y, Hessa T, von Heijne G, Lee JK, Kodama I, Sakaguchi M, Uozumi N., Free PMC Article | 01/21/2010 |