| Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model. | Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model.
Nakayama T, Singh AK, Fukutomi T, Uchida N, Terao Y, Hamada H, Muraoka T, Muthusamy E, Kundu TK, Akagawa K. | 05/9/2024 |
| Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway. | Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.
Liu J, Meng F, Wang W, Wu M, Zhang Y, Cui M, Qiu C, Hu F, Zhao D, Wang D, Liu C, Liu D, Xu Z, Wang Y, Li W, Li C., Free PMC Article | 10/24/2023 |
| The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis. | The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
Lee SY, Park SY, Lee SH, Kim H, Kwon JH, Yoo JY, Kim K, Park MS, Lee CG, Elias JA, Sohn MH, Shim HS, Yoon HG., Free PMC Article | 09/8/2023 |
| Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. | Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation.
Zhou P, VanDusen NJ, Zhang Y, Cao Y, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K, Pu WT., Free PMC Article | 05/28/2023 |
| EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2alpha expression in diabetic nephropathy. | EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2α expression in diabetic nephropathy.
Gong Y, Dou Y, Wang L, Wang X, Zhao Z. | 09/10/2022 |
| KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. | KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.
Kim KB, Kabra A, Kim DW, Xue Y, Huang Y, Hou PC, Zhou Y, Miranda LJ, Park JI, Shi X, Bender TP, Bushweller JH, Park KS., Free PMC Article | 04/23/2022 |
| p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. | p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.
Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S., Free PMC Article | 03/26/2022 |
| Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression. | Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression.
Guo T, Xing Y, Chen Z, Zhu H, Yang L, Xiao Y, Xu J. | 03/26/2022 |
| p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia. | p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia.
Man N, Mas G, Karl DL, Sun J, Liu F, Yang Q, Torres-Martin M, Itonaga H, Martinez C, Chen S, Xu Y, Duffort S, Hamard PJ, Chen C, Zucconi BE, Cimmino L, Yang FC, Xu M, Cole PA, Figueroa ME, Nimer SD., Free PMC Article | 03/19/2022 |
| The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. | The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Li W, Wang Y, Zhu L, Du S, Mao J, Wang Y, Wang S, Bo Q, Tu Y, Yi Q., Free PMC Article | 02/5/2022 |
| Knockdown of MIR93HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR498 via EP300. | Knockdown of MIR9‑3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR‑498 via EP300.
Li F, Liang Y, Ying P., Free PMC Article | 01/8/2022 |
| microRNA-148a-3p-targeting p300 protects against osteoblast differentiation and osteoporotic bone reconstruction. | microRNA-148a-3p-targeting p300 protects against osteoblast differentiation and osteoporotic bone reconstruction.
Liu N, Sun Y. | 11/6/2021 |
| De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy. | De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
Lu P, Xu Y, Sheng ZY, Peng XG, Zhang JJ, Wu QH, Wu YQ, Cheng XS, Zhu K. | 10/23/2021 |
| MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells. | MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.
Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake J, Sakurai H, Nishi E, Maegawa H, Imamura T., Free PMC Article | 08/14/2021 |
| Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300. | Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
Lee KH, Woo J, Kim J, Lee CH, Yoo CG. | 07/3/2021 |
| Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice. | Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.
Sanders YY, Lyv X, Zhou QJ, Xiang Z, Stanford D, Bodduluri S, Rowe SM, Thannickal VJ., Free PMC Article | 05/22/2021 |
| Differential contribution of p300 and CBP to regulatory element acetylation in mESCs. | Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.
Martire S, Nguyen J, Sundaresan A, Banaszynski LA., Free PMC Article | 02/6/2021 |
| CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. | CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA., Free PMC Article | 01/9/2021 |
| Type 2 diabetes-induced overactivation of P300 contributes to skeletal muscle atrophy by inhibiting autophagic flux. | Type 2 diabetes-induced overactivation of P300 contributes to skeletal muscle atrophy by inhibiting autophagic flux.
Fan Z, Wu J, Chen QN, Lyu AK, Chen JL, Sun Y, Lyu Q, Zhao YX, Guo A, Liao ZY, Yang YF, Zhu SY, Jiang XS, Chen B, Xiao Q. | 10/3/2020 |
| CBP/p300 acts as a tumour suppressor in epidermal keratinocytes by counteracting EGFR-Ras-Erk signaling, to prevent skin neoplasms. | CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.
Ichise T, Yoshida N, Ichise H. | 04/18/2020 |
| p300-mediated histone acetylation regulates the expression of the asthma susceptibility gene ORMDL3, thus improving the process of airway remodeling in asthma. | p300 mediates the histone acetylation of ORMDL3 to affect airway inflammation and remodeling in asthma.
Cheng Q, Shang Y, Huang W, Zhang Q, Li X, Zhou Q. | 03/21/2020 |
| Muscle-specific loss of either p300 or CBP, be it germline or in adulthood, does not impact energy expenditure, glucose tolerance, or skeletal muscle insulin action. | Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.
Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S., Free PMC Article | 01/4/2020 |
| Combined loss of Crebbp and Ep300 completely abrogated GC formation. | Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.
Meyer SN, Scuoppo C, Vlasevska S, Bal E, Holmes AB, Holloman M, Garcia-Ibanez L, Nataraj S, Duval R, Vantrimpont T, Basso K, Brooks N, Dalla-Favera R, Pasqualucci L., Free PMC Article | 12/21/2019 |
| our results indicate that high-dose GluOC triggers necroptosis through upregulation of FasL at the plasma membrane in a manner dependent of activation of CREB-p300, followed by the activation of Fas signaling in neighboring adipocytes | Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300.
Otani T, Matsuda M, Mizokami A, Kitagawa N, Takeuchi H, Jimi E, Inai T, Hirata M., Free PMC Article | 12/14/2019 |
| these data imply an important role for p300 in the pathophysiology of diabetes. | Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
Ruiz L, Gurlo T, Ravier MA, Wojtusciszyn A, Mathieu J, Brown MR, Broca C, Bertrand G, Butler PC, Matveyenko AV, Dalle S, Costes S., Free PMC Article | 11/9/2019 |