| Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer. | Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W. | 07/7/2023 |
| A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus. | A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.
Kanemoto Y, Nishimura K, Hayakawa A, Sawada T, Amano R, Mori J, Kurokawa T, Murakami Y, Kato S., Free PMC Article | 06/11/2022 |
| Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17beta-HSD2. | Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.
Sager CP, Weber S, Negri M, Banachowicz P, Möller G, Adamski J, Hartmann RW, Marchais-Oberwinkler S. | 05/8/2021 |
| Our findings provide evidence of the clinical relevance, significance, and regulation of HSD17B2 in prostate cancer progression, which might provide new strategies for clinical management by targeting the functional silencing mechanisms of HSD17B2. | Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression.
Gao X, Dai C, Huang S, Tang J, Chen G, Li J, Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z., Free PMC Article | 04/25/2020 |
| ATRA treatment decreased the mRNA expression of 17-beta-dehydrogenase 2 (HSD17B2) which converts estradiol into estrone in a dose-dependent manner | Retinoic acid has the potential to suppress endometriosis development.
Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T, Asada H, Tamura H, Nakai A, Sugino N., Free PMC Article | 08/27/2016 |
| Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI. | Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women.
Hosono S, Ito H, Oze I, Higaki Y, Morita E, Takashima N, Suzuki S, Shimatani K, Mikami H, Ohnaka K, Ozaki E, Katsuura-Kamano S, Kubo M, Nagata C, Naito M, Hamajima N, Tanaka H, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group. | 06/28/2016 |
| Data indicate that conversion of testosterone to 4-dione detected in abdominal adipose tissue is caused by 17b-HSD type 2 which is localized in the vasculature of the adipose compartment. | Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2.
Fouad Mansour M, Pelletier M, Boulet MM, Mayrand D, Brochu G, Lebel S, Poirier D, Fradette J, Cianflone K, Luu-The V, Tchernof A. | 06/4/2016 |
| This study demonstrated that HSD17B2 transcript and protein levels are linked to some clinicopathological features in gastric cancer. | Expression of 17β-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer.
Frycz BA, Murawa D, Borejsza-Wysocki M, Marciniak R, Murawa P, Drews M, Jagodziński PP. | 02/13/2016 |
| High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy. | The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.
Lee YE, He HL, Shiue YL, Lee SW, Lin LC, Wu TF, Chang IW, Lee HH, Li CF. | 01/23/2016 |
| In both arm and subumbilical skin biopsy of patients with idiopathic hirsutism, there was an up-regulation of HSD17B2 mRNA expression. | Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH.
Taheri S, Zararsiz G, Karaburgu S, Borlu M, Ozgun MT, Karaca Z, Tanriverdi F, Dundar M, Kelestimur F, Unluhizarci K. | 11/21/2015 |
| Single nucleotide polymorphism in HSD17B2 gene is associated with hepatocellular carcinoma. | Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk.
Zhang LS, Yuan F, Guan X, Li J, Liu XL, Sun J, Liu B, Ma W, Deng FM. | 02/28/2015 |
| This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression | Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.
Lévesque E, Laverdière I, Audet-Walsh E, Caron P, Rouleau M, Fradet Y, Lacombe L, Guillemette C. | 01/10/2015 |
| SNP variants in the 17beta-HSD2 and 17beta-HSD7 genes and 17beta-HSD7 copy number is associated with increased estradiol levels in breast cancer tissues. | Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue.
Straume AH, Knappskog S, Lønning PE. | 01/3/2015 |
| overexpression of 17beta-HSD2 in sebocytes significantly increased the androstenedione production and markedly decreased the amounts of testosterone and dihydrotestosterone | Expression of steroidogenic enzymes in human sebaceous glands.
Inoue T, Miki Y, Kakuo S, Hachiya A, Kitahara T, Aiba S, Zouboulis CC, Sasano H. | 10/4/2014 |
| no significant difference in the genotype and allele frequencies of rs8191246 between uterine leiomyoma cases and controls | Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women.
Cong RJ, Huang ZY, Cong L, Ye Y, Wang Z, Zha L, Cao LP, Su XW, Yan J, Li YB. | 01/12/2013 |
| Single-nucleotide polymorphisms in HSD17B2, HSD17B3 and HSD17B1 are associated with plasma testosterone level and prostate cancer aggressiveness. | The impact of common genetic variations in genes of the sex hormone metabolic pathways on steroid hormone levels and prostate cancer aggressiveness.
Sun T, Oh WK, Jacobus S, Regan M, Pomerantz M, Freedman ML, Lee GS, Kantoff PW., Free PMC Article | 04/7/2012 |
| Data indicate that 17betaHSD2 expression is higher in HUAEC than in HUVEC; activity is higher in umbilical arteries near the placenta. These data are consistent with higher sex steroid inactivation in the arterial system of the foeto-placental unit. | Human type 2 17beta-hydroxysteroid dehydrogenase in umbilical vein and artery endothelial cells: differential inactivation of sex steroids according to the vessel type.
Simard M, Drolet R, Blomquist CH, Tremblay Y. | 02/25/2012 |
| Data show that steroidogenic enzymes (AKR1C3, HSD17B2, UGT2B15 and UGT2B17) and stem/progenitor cell markers CK5 and ABCG2 were upregulated in castration resistant prostate cancer. | Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.
Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA., Free PMC Article | 12/31/2011 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women.
Lin J, Zee RY, Liu KY, Zhang SM, Lee IM, Manson JE, Giovannucci E, Buring JE, Cook NR., Free PMC Article | 04/7/2010 |
| BRCA1 and HSD17B2 genes may increase the risk of developing breast cancer via enhanced estradiol activity. | Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue.
Bhavani V, Srinivasulu M, Ahuja YR, Hasan Q. | 01/21/2010 |
| HSD17B2 modulates estrogen-independent and estrogen-dependent action in transgenic female mice. | Sex steroid-dependent and -independent action of hydroxysteroid (17beta) Dehydrogenase 2: evidence from transgenic female mice.
Shen Z, Saloniemi T, Rönnblad A, Järvensivu P, Pakarinen P, Poutanen M. | 01/21/2010 |
| preference of 17betaHSD2 for E2 oxidation strongly resists alteration by genetic & metabolic means. Findings suggest additional structural features, beyond lack of a specific Arg residue, disfavor NADPH binding & thus support E2 oxidation by 17betaHSD2 | Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells.
Sherbet DP, Guryev OL, Papari-Zareei M, Mizrachi D, Rambally S, Akbar S, Auchus RJ., Free PMC Article | 01/21/2010 |
| Data suggest that the 17HSD1/17HSD2 ratio might be useful as a predictive factor for tamoxifen treatment in ER-positive breast cancer patients. | Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients.
Jansson A, Delander L, Gunnarsson C, Fornander T, Skoog L, Nordenskjöld B, Stål O. | 01/21/2010 |