| Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2. | Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2.
Joutsen J, Pessa JC, Jokelainen O, Sironen R, Hartikainen JM, Sistonen L., Free PMC Article | 05/2/2024 |
| Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China. | Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
Cao Z, Ma L, Cai W, Niu X, Yang N, Ni J, Wang X, Wei M, Chen S, Li Y. | 09/27/2023 |
| Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases. | Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases.
Tokunaga Y, Otsuyama KI, Kakuta S, Hayashida N., Free PMC Article | 01/7/2023 |
| CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. | CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot É, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard S, Sabéran-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V., Free PMC Article | 11/26/2022 |
| Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. | Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
Gupta N, Sarkar S, Mehta P, Sankhwar SN, Rajender S. | 09/17/2022 |
| Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis. | Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis.
Wen Y, Niu J, Zhang F, Wu J, Li M, Sun Y, Wang W, Xia S, Tan Y, Wang K, Miao Y. | 07/3/2021 |
| The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction. | The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction.
Santopolo S, Riccio A, Rossi A, Santoro MG., Free PMC Article | 03/6/2021 |
| Heat shock transcription factor 2 reduces the secretion of IL-1beta by inhibiting NLRP3 inflammasome activation in ulcerative colitis. | Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis.
Zhang F, Zhao W, Zhou J, Wang W, Luo J, Feng Y, Wu J, Li M, Wang K, Niu J, Miao Y. | 01/23/2021 |
| Heat shock transcription factor 2 inhibits intestinal epithelial cell apoptosis through the mitochondrial pathway in ulcerative colitis. | Heat shock transcription factor 2 inhibits intestinal epithelial cell apoptosis through the mitochondrial pathway in ulcerative colitis.
Wang W, Zhang F, Li X, Luo J, Sun Y, Wu J, Li M, Wen Y, Liang H, Wang K, Niu J, Miao Y. | 12/26/2020 |
| Heat-shock transcription factor 2 promotes sodium butyrate-induced autophagy by inhibiting mTOR in ulcerative colitis. | Heat-shock transcription factor 2 promotes sodium butyrate-induced autophagy by inhibiting mTOR in ulcerative colitis.
Zhang F, Wang W, Niu J, Yang G, Luo J, Lan D, Wu J, Li M, Sun Y, Wang K, Miao Y. | 10/31/2020 |
| Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells. | ALG3 Is Activated by Heat Shock Factor 2 and Promotes Breast Cancer Growth.
Yang Y, Zhou Y, Xiong X, Huang M, Ying X, Wang M., Free PMC Article | 10/6/2018 |
| MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction. | MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction.
Feng H, Wang S, Guo L, Punekar AS, Ladenstein R, Wang DC, Liu W., Free PMC Article | 01/13/2018 |
| HSF2 is a direct target of miR202 with a binding site on 3'-UTR of HSF2 mRNA in esophageal squamous cell carcinoma cells. | miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2.
Meng X, Chen X, Lu P, Ma W, Yue D, Song L, Fan Q., Free PMC Article | 03/18/2017 |
| This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies. | Heat-shock factor 2 is a suppressor of prostate cancer invasion.
Björk JK, Åkerfelt M, Joutsen J, Puustinen MC, Cheng F, Sistonen L, Nees M., Free PMC Article | 08/27/2016 |
| Presented are the crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA. | Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ., Free PMC Article | 07/2/2016 |
| the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop. | HSF2 autoregulates its own transcription.
Park SM, Kim SA, Ahn SG. | 06/28/2016 |
| HSF2 can induce histone activation.Set1/MLL complex is indispensable for the transcriptional ability of HSF2. | Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2.
Hayashida N. | 05/7/2016 |
| Nuclear HSF2 and HSF4 bound to HSF1 only after heat shock. | Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy.
Pack CG, Ahn SG. | 09/12/2015 |
| HSF2 appears to be a potential novel molecular marker for ulcerative colitis | Heat shock factor 2 levels are associated with the severity of ulcerative colitis.
Miao J, Niu J, Wang K, Xiao Y, Du Y, Zhou L, Duan L, Li S, Yang G, Chen L, Tong M, Miao Y., Free PMC Article | 01/31/2015 |
| the condensed chromatin of HSF2-deficient cells is accessible for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression. | Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.
Elsing AN, Aspelin C, Björk JK, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L., Free PMC Article | 11/22/2014 |
| Data indicate that both heat shock factors HSF1 and HSF2 are recruited to the arsenite-inducible RNA-associated protein (AIRAP) promoter and regulate bortezomib-induced AIRAP expression. | The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes.
Rossi A, Riccio A, Coccia M, Trotta E, La Frazia S, Santoro MG., Free PMC Article | 08/9/2014 |
| Results indicate the importance of the cell cycle phase in transcriptional responses and identify the specific mechanisms for HSF1 and HSF2 in transcriptional orchestration. | Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells.
Vihervaara A, Sergelius C, Vasara J, Blom MA, Elsing AN, Roos-Mattjus P, Sistonen L., Free PMC Article | 12/21/2013 |
| These results support a role for HSF2 in the pathogenesis of IA and further implicate this transcription factor as a potential therapeutic target. | A dominant-negative mutation of HSF2 associated with idiopathic azoospermia.
Mou L, Wang Y, Li H, Huang Y, Jiang T, Huang W, Li Z, Chen J, Xie J, Liu Y, Jiang Z, Li X, Ye J, Cai Z, Gui Y. | 03/16/2013 |
| our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. | Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity.
Kim SA, Yoon JH, Ahn SG. | 12/10/2011 |
| HSF2 and HSF4 regulate transcription of HIF-1alpha and that a critical balance between these HSFs is required to maintain HIF-alpha expression in a repressed state. | Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.
Chen R, Liliental JE, Kowalski PE, Lu Q, Cohen SN. | 08/20/2011 |