| Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells. | Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
Rinehart L, Stewart WE, Luffman N, Wawersik M, Kerscher O., Free PMC Article | 03/22/2024 |
| Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis. | Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis.
Truman JW, Riddiford LM., Free PMC Article | 05/7/2022 |
| chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche. | chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.
Tseng CY, Burel M, Cammer M, Harsh S, Flaherty MS, Baumgartner S, Bach EA., Free PMC Article | 02/12/2022 |
| miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. | miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila.
Pandey M, Bansal S, Bar S, Yadav AK, Sokol NS, Tennessen JM, Kapahi P, Chawla G., Free PMC Article | 12/4/2021 |
| let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State. | let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
Wu YC, Chawla G, Sokol N., Free PMC Article | 07/17/2021 |
| Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors Chinmo and Broad. | Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.
Narbonne-Reveau K, Maurange C., Free PMC Article | 11/30/2019 |
| The BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of gamma and alpha'beta' MB neurons | Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.
Marchetti G, Tavosanis G. | 08/4/2018 |
| Transcriptional control of the sex determination hierarchy by Chinmo is critical for sex maintenance in sexually dimorphic tissues and is vital in the preservation of fertility. | Chinmo prevents transformer alternative splicing to maintain male sex identity.
Grmai L, Hudry B, Miguel-Aliaga I, Bach EA., Free PMC Article | 07/21/2018 |
| Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth. | Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal.
Dillard C, Narbonne-Reveau K, Foppolo S, Lanet E, Maurange C. | 03/31/2018 |
| we show that two co-transcribed Drosophila miRNAs, let-7 and miR-125, non-redundantly regulate a common target, the transcription factor Chronologically Inappropriate Morphogenesis (Chinmo). We first characterize novel adult phenotypes associated with loss of both let-7 and miR-125, which are derived from a common, polycistronic transcript that also encodes a third miRNA, miR-100. | A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila.
Chawla G, Deosthale P, Childress S, Wu YC, Sokol NS., Free PMC Article | 05/27/2017 |
| chinmo is necessary and sufficient to promote a male identity in adult gonadal somatic cells; the sexual identity of somatic cells can be reprogrammed in the adult Drosophila ovary as well as in the testis. | Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary.
Ma Q, de Cuevas M, Matunis EL., Free PMC Article | 08/6/2016 |
| ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of DoublesexM | The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche.
Ma Q, Wawersik M, Matunis EL., Free PMC Article | 02/14/2015 |
| Let-7 and miR-125, cotranscribed from the let-7-complex (let-7-C) locus, regulate the transcription factor chinmo to control temporal cell fate in the mushroom body (MB) lineage. | Let-7-complex microRNAs regulate the temporal identity of Drosophila mushroom body neurons via chinmo.
Wu YC, Chen CH, Mercer A, Sokol NS., Free PMC Article | 10/13/2012 |
| Chinmo is a key effector of JAK/STAT signaling in a variety of developmental and pathological contexts | chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.
Flaherty MS, Salis P, Evans CJ, Ekas LA, Marouf A, Zavadil J, Banerjee U, Bach EA., Free PMC Article | 05/10/2010 |
| identified novel BTB-zinc finger protein, Chinmo, governing neuronal temporal identity during postembryonic brain development; results suggest temporal gradient of Chinmo helps specify distinct birth order-dependent cell fates in a neuronal lineage | Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity.
Zhu S, Lin S, Kao CF, Awasaki T, Chiang AS, Lee T. | 01/21/2010 |