| Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1. | Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1.
Nemtsova Y, Steinert BL, Wharton KA., Free PMC Article | 06/7/2023 |
| Differential mitochondrial roles for alpha-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation. | Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Krzystek TJ, Banerjee R, Thurston L, Huang J, Swinter K, Rahman SN, Falzone TL, Gunawardena S., Free PMC Article | 01/29/2022 |
| Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics in Drosophila cellularization. | Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics in Drosophila cellularization.
Chowdhary S, Madan S, Tomer D, Mavrakis M, Rikhy R., Free PMC Article | 06/12/2021 |
| Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. | Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
Terriente-Felix A, Wilson EL, Whitworth AJ., Free PMC Article | 01/2/2021 |
| The reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors. | scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila.
Yadav AK, Srikrishna S. | 03/9/2019 |
| Data show that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan. | Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.
Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW., Free PMC Article | 12/23/2017 |
| Study showed that exogenous expression of Drp1 could promote crawling ability, reduced the level of ATP in Drosophila brain and suppressed neuronal degeneration, suggesting that Drp1 is involved in the pathogenesis of Alzheimer disease. | Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimer's disease in the Aβ42 transgenic Drosophila model.
Lv F, Yang X, Cui C, Su C., Free PMC Article | 09/16/2017 |
| Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity. | Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.
Chin YH, Lee A, Kan HW, Laiman J, Chuang MC, Hsieh ST, Liu YW. | 07/16/2016 |
| Debcl modulates Drp1 mitochondrial localization during apoptosis. | The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis.
Clavier A, Ruby V, Rincheval-Arnold A, Mignotte B, Guénal I. | 06/4/2016 |
| Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila | DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis.
Mitra K, Rikhy R, Lilly M, Lippincott-Schwartz J., Free PMC Article | 08/11/2012 |
| Alterations in both mitochondrial morphology and ATP production caused by either parkin or PINK1 loss of function could be rescued by the mitochondrial fusion proteins Mfn2 and OPA1 or by a dominant negative mutant of the fission protein Drp1. | Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF., Free PMC Article | 01/21/2010 |
| functions in the anchoring, unfurling, and elongation of mitochondria during sperm formation | Roles for Drp1, a dynamin-related protein, and milton, a kinesin-associated protein, in mitochondrial segregation, unfurling and elongation during Drosophila spermatogenesis.
Aldridge AC, Benson LP, Siegenthaler MM, Whigham BT, Stowers RS, Hales KG. | 01/21/2010 |