| PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development. | PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development.
Bamgbose G, Tulin A., Free PMC Article | 01/31/2024 |
| Muscle PARP1 inhibition extends lifespan through AMPKalpha PARylation and activation in Drosophila. | Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X, Liu T., Free PMC Article | 03/24/2023 |
| Early loss of endogenous NAD[+] following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition. | Early loss of endogenous NAD(+) following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
Sarkar A, Dutta S, Sur M, Chakraborty S, Dey P, Mukherjee P. | 03/23/2023 |
| Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. | Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Yu Y, Fedele G, Celardo I, Loh SHY, Martins LM., Free PMC Article | 09/25/2021 |
| Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila. | Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.
Bordet G, Lodhi N, Guo D, Kossenkov A, Tulin AV., Free PMC Article | 03/20/2021 |
| PARP1 is a versatile factor in the regulation of mRNA stability and decay. | PARP1 is a versatile factor in the regulation of mRNA stability and decay.
Matveeva EA, Mathbout LF, Fondufe-Mittendorf YN., Free PMC Article | 10/3/2020 |
| The long-term chromatin loosening required to sustain transcription takes place when the C-terminal domain of PARP-1 binds to chromatin by interacting with histone H4 in the nucleosome. | Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes.
Thomas C, Ji Y, Wu C, Datz H, Boyle C, MacLeod B, Patel S, Ampofo M, Currie M, Harbin J, Pechenkina K, Lodhi N, Johnson SJ, Tulin AV., Free PMC Article | 04/4/2020 |
| The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process. | DNA maintenance following bleomycin-induced strand breaks does not require poly(ADP-ribosyl)ation activation in Drosophila S2 cells.
Ishak L, Moretton A, Garreau-Balandier I, Lefebvre M, Alziari S, Lachaume P, Morel F, Farge G, Vernet P, Dubessay P. | 05/20/2017 |
| A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin mutants. | Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.
Lehmann S, Costa AC, Celardo I, Loh SH, Martins LM., Free PMC Article | 12/24/2016 |
| chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av in a nucleosome positioned in promoter regions of PARP-1-dependent genes | Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation.
Thomas CJ, Kotova E, Andrake M, Adolf-Bryfogle J, Glaser R, Regnard C, Tulin AV., Free PMC Article | 05/3/2014 |
| Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis | Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli.
Boamah EK, Kotova E, Garabedian M, Jarnik M, Tulin AV., Free PMC Article | 06/30/2012 |
| PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss. | Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70.
Petesch SJ, Lis JT., Free PMC Article | 03/31/2012 |
| Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility. | Effect of PARP-1 overexpression and pharmacological inhibition of NF-kB on the lifespan of Drosophila melanogaster.
Shaposhnikov MV, Moskalev AA, Plyusnina EN. | 02/11/2012 |
| PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av). | Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin.
Kotova E, Lodhi N, Jarnik M, Pinnola AD, Ji Y, Tulin AV., Free PMC Article | 07/2/2011 |
| inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription | The roles of PARP1 in gene control and cell differentiation.
Ji Y, Tulin AV., Free PMC Article | 01/1/2011 |
| demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements. | Uncoupling of the transactivation and transrepression functions of PARP1 protein.
Kotova E, Jarnik M, Tulin AV., Free PMC Article | 05/10/2010 |
| PARP1 is required for protein targeting to Cajal body. | Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body.
Kotova E, Jarnik M, Tulin AV., Free PMC Article | 01/21/2010 |
| propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff | Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci.
Tulin A, Spradling A. | 01/21/2010 |
| PARP-e autoregulates Parp transcription | The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development.
Tulin A, Stewart D, Spradling AC., Free PMC Article | 01/21/2010 |