| Data suggest that midline protein (mid) and H15 protein (H15) specify ventral fate through inhibition of decapentaplegic protein (Dpp) signaling and through coordinating the repression of genes in the ventral leg. | The selector genes midline and H15 control ventral leg pattern by both inhibiting Dpp signaling and specifying ventral fate.
Svendsen PC, Phillips LA, Deshwar AR, Ryu JR, Najand N, Brook WJ. | 05/23/2020 |
| Taken together, the authors propose that Mid regulates wing development by repressing wg and hh in Drosophila. | The T-box transcription factor Midline regulates wing development by repressing wingless and hedgehog in Drosophila.
Fu CL, Wang XF, Cheng Q, Wang D, Hirose S, Liu QX., Free PMC Article | 05/5/2018 |
| Mid and dFOXO serve as critical effectors of cell fate specification and survival within integrated Notch, InR/dAkt, and JNK signaling pathways during 3(o)L and pupal eye imaginal disc development. | The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival.
Chen QB, Das S, Visic P, Buford KD, Zong Y, Buti W, Odom KR, Lee H, Leal SM., Free PMC Article | 01/16/2016 |
| Mid functions in the progenitor to direct development of lateral transverse (LT) muscles LT3 and LT4, and later in the founder cells to influence whichever of these differentiation profiles is selected. | Muscle cell fate choice requires the T-box transcription factor midline in Drosophila.
Kumar RP, Dobi KC, Baylies MK, Abmayr SM., Free PMC Article | 11/28/2015 |
| Mid and Lola are required for somatic gonadal precursor cell cluster fusion, germ cell ensheathment, and gonad compaction in the developing Drosophila gonads. | Transcriptional regulation of Drosophila gonad formation.
Tripathy R, Kunwar PS, Sano H, Renault AD. | 09/20/2014 |
| Previously, we had shown that midline ensures ancestry-dependent fate specification in a neuronal lineage | The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord.
Manavalan MA, Gaziova I, Bhat KM., Free PMC Article | 08/23/2014 |
| The Drosophila Mid proten functions within the Notch-Delta signaling pathway to specify sensory organ precursor cell fates and regulates cell survival within the eye imaginal disc. | The Drosophila T-box transcription factor Midline functions within the Notch-Delta signaling pathway to specify sensory organ precursor cell fates and regulates cell survival within the eye imaginal disc.
Das S, Chen QB, Saucier JD, Drescher B, Zong Y, Morgan S, Forstall J, Meriwether A, Toranzo R, Leal SM., Free PMC Article | 06/14/2014 |
| analysis of a consensus binding site for the Drosophila melanogaster Tbx20 homolog midline | In vitro site selection of a consensus binding site for the Drosophila melanogaster Tbx20 homolog midline.
Najand N, Ryu JR, Brook WJ., Free PMC Article | 05/11/2013 |
| Midline binds the Groucho co-repressor directly via the engrailed homology-1 domain and requires an intact engrailed-homology-1 domain to repress wingless. | The Tbx20 homolog Midline represses wingless in conjunction with Groucho during the maintenance of segment polarity.
Formaz-Preston A, Ryu JR, Svendsen PC, Brook WJ. | 11/3/2012 |
| Tin is a direct regulator of midline in fly heart development. | Tinman is a direct activator of midline in the Drosophila dorsal vessel.
Ryu JR, Najand N, Brook WJ. | 05/14/2011 |
| Results suggest that midline and H15 may be considered as the selector genes for ventral leg fate. | The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg.
Svendsen PC, Formaz-Preston A, Leal SM, Brook WJ. | 01/21/2010 |
| Drosophila T-box protein Midline controls expression of genes encoding components of two major axon guidance systems: Frazzled, ROBO, and Slit | Midline governs axon pathfinding by coordinating expression of two major guidance systems.
Liu QX, Hiramoto M, Ueda H, Gojobori T, Hiromi Y, Hirose S., Free PMC Article | 01/21/2010 |
| Nmr1 and nmr2 appear to act together as members of the combinatorial code of transcription factors that govern neuronal subtype identity in the central nervous system. | Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster.
Leal SM, Qian L, Lacin H, Bodmer R, Skeath JB., Free PMC Article | 01/21/2010 |
| Data suggest that neuromancer 1 and 2 act both in concert with and subsequent to pannier and tinman in cardiac specification and differentiation. | Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart.
Qian L, Liu J, Bodmer R. | 01/21/2010 |
| In odd-numbered abdominal segments, Mid and H15 activity plays an important role in restricting the expression of Wg to a single domain. | Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless.
Buescher M, Svendsen PC, Tio M, Miskolczi-McCallum C, Tear G, Brook WJ, Chia W. | 01/21/2010 |