| ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway. | ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway.
Pan X, Tan J, Weng X, Du R, Jiang Y, Weng Y, Zhou D, Shen Y., Free PMC Article | 05/29/2021 |
| miR-1301-3p inhibits cell proliferation via inducing cell cycle arrest and apoptosis through targeting ICT1, and might be a therapeutic target for BC. | MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1.
Peng X, Yan B, Shen Y. | 02/23/2019 |
| High ICT1 expression is associated with leukemia. | Knockdown of immature colon carcinoma transcript 1 induces suppression of proliferation, S-phase arrest and apoptosis in leukemia cells.
Li GY, Liu JZ, Zhang L, Liu GZ, Li SJ, Xiao TW, Wang JX, Wang LX, Hou M. | 09/1/2018 |
| ICT1 overexpression notably predicted poor prognosis of gastric cancer patients. | miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells.
Tao Y, Song Y, Han T, Wang C, Zhao T, Gu Y. | 07/28/2018 |
| Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells. | Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance.
Chang W, Yu Z, Tian M, Lin X. | 07/28/2018 |
| ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro. | Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells.
Wang Z, Jin G, Wu Q, Wang R, Li Y. | 05/19/2018 |
| The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. | A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes.
Loza O, Heemskerk I, Gordon-Bar N, Amir-Zilberstein L, Jung Y, Sprinzak D., Free PMC Article | 05/19/2018 |
| our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis. | Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells.
Wang Y, He J, Zhang S, Yang Q, Wang B, Liu Z, Wu X., Free PMC Article | 05/5/2018 |
| ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways. | Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer.
Lao X, Feng Q, He G, Ji M, Zhu D, Xu P, Tang W, Xu J, Qin X. | 01/20/2018 |
| ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells. | ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma.
Xie W, Wu M, Fu T, Li X, Wang Z, Hu Y, Zhu L, Zhang G. | 09/23/2017 |
| ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2, caspase-3, CDK1, CDK2 and cyclin B. | ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis.
Wang C, Liang C, Feng W, Xia X, Chen F, Qiao E, Zhang X, Chen D, Ling Z, Yang H. | 04/29/2017 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes. | A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.
Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM., Free PMC Article | 05/10/2010 |