| Suppression of Wnt/beta-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease. | Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.
Macyczko JR, Wang N, Zhao J, Ren Y, Lu W, Ikezu TC, Zhao N, Liu CC, Bu G, Li Y., Free PMC Article | 12/31/2022 |
| Identification of a regulatory pathway inhibiting adipogenesis via RSPO2. | Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.
Dong H, Sun W, Shen Y, Baláz M, Balázová L, Ding L, Löffler M, Hamilton B, Klöting N, Blüher M, Neubauer H, Klein H, Wolfrum C., Free PMC Article | 03/5/2022 |
| RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis. | RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z, Li Z, Yang Z, Li R, Xue X, Gao Y, Yue F, Zhang XH, Hu G, Wang Y, Li Y, Chen G, Siwko S, Gartland A, Wang N, Xiao J, Liu M, Luo J., Free PMC Article | 02/19/2022 |
| Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture. | Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture.
Samulėnas G, Smalinskienė A, Rimdeika R, Braziulis K, Fomkinas M, Paškevičius R., Free PMC Article | 02/12/2022 |
| RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia. | RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. | 02/12/2022 |
| Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis. | Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
Singla B, Lin HP, Chen A, Ahn W, Ghoshal P, Cherian-Shaw M, White J, Stansfield BK, Csányi G., Free PMC Article | 01/29/2022 |
| R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth. | R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth.
De Cian MC, Gregoire EP, Le Rolle M, Lachambre S, Mondin M, Bell S, Guigon CJ, Chassot AA, Chaboissier MC., Free PMC Article | 11/13/2021 |
| R-spondin2 Suppresses the Progression of Hepatocellular Carcinoma via MAPK Signaling Pathway. | R-spondin2 Suppresses the Progression of Hepatocellular Carcinoma via MAPK Signaling Pathway.
Zheng C, Zhou F, Shi LL, Xu GF, Zhang B, Wang L, Zhuge Y, Zou XP, Wang Y. | 09/4/2021 |
| RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway. | RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.
Wang Z, Wang Y, Ma X, Dang C. | 08/14/2021 |
| R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. | R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R., Free PMC Article | 03/27/2021 |
| R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers. | R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.
Conboy CB, Vélez-Reyes GL, Rathe SK, Abrahante JE, Temiz NA, Burns MB, Harris RS, Starr TK, Largaespada DA., Free PMC Article | 02/6/2021 |
| A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials. | A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials.
Berger MD, Ning Y, Stintzing S, Heinemann V, Cao S, Zhang W, Yang D, Miyamoto Y, Suenaga M, Schirripa M, Hanna DL, Soni S, Puccini A, Tokunaga R, Naseem M, Battaglin F, Cremolini C, Falcone A, Loupakis F, Lenz HJ., Free PMC Article | 10/31/2020 |
| High RSPO2 expression is associated with gastric cancer migration and invasion. | RSPO2 enhances cell invasion and migration via the WNT/β-catenin pathway in human gastric cancer.
Zhang H, Han X, Wei B, Fang J, Hou X, Lan T, Wei H. | 07/25/2020 |
| An EIF3E-RSPO2 fusion was detected in three colorectal serrated polyps | EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma.
Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S. | 01/25/2020 |
| our studies demonstrate that Rspo2-LGR4 is crucial for the growth, migration and invasion, EMT and stem-like properties of TSCC cells. These actions occur through the activation of Wnt/beta-catenin signaling pathway. | R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling.
Zhang L, Song Y, Ling Z, Li Y, Ren X, Yang J, Wang Z, Xia J, Zhang W, Cheng B., Free PMC Article | 12/21/2019 |
| Our data show that Wnt pathway inhibition could provide an effective treatment for cancers containing RSPO2 fusion. The RSPO2 fusion will serve as a good biomarker for screening patients to support clinical treatment of digestive system cancers using Wnt pathway inhibitors. | Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor.
Li C, Cao J, Zhang N, Tu M, Xu F, Wei S, Chen X, Xu Y., Free PMC Article | 12/14/2019 |
| RSPO2, but not SPON1, specifically promoted the differentiation of midbrain dopaminergic (mDA) neuroblasts into mDA neurons in mouse primary cultures and embryonic stem cells (ESCs). | The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
Gyllborg D, Ahmed M, Toledo EM, Theofilopoulos S, Yang S, Ffrench-Constant C, Arenas E., Free PMC Article | 09/21/2019 |
| Study in different human cancer cell lines revealed that Rspo2 is C-mannosylated at Trp150 and Trp153, and these modifications alter its secretory levels and intracellular trafficking. In addition, C-mannosylation of Rspo2 regulated the agonistic activity of Rspo2 in the Wnt/beta-catenin signaling pathway and on cancer cell migration. These results suggested that Cmannosylation of Rspo2 may promote cancer progression. | C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.
Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N, Simizu S. | 08/31/2019 |
| The RSPO2 gene rearrangement leads to oncogenic activation of the Wingless-Type MMTV Integration Site Family signalling pathway in hepatocellular adenomas and hepatocellular carcinoma, represents an alternative mechanism for the development of b-HCA and may drive malignant transformation without additional TERT promoter mutation. | RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours.
Longerich T, Endris V, Neumann O, Rempel E, Kirchner M, Abadi Z, Uhrig S, Kriegsmann M, Weiss KH, Breuhahn K, Mehrabi A, Weber TF, Wilkens L, Straub BK, Rosenwald A, Schulze F, Brors B, Froehling S, Pellegrino R, Budczies J, Schirmacher P, Stenzinger A. | 07/27/2019 |
| It promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/beta-catenin signaling pathway. | R-spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β-catenin signaling pathway.
Arima M, Hasegawa D, Yoshida S, Mitarai H, Tomokiyo A, Hamano S, Sugii H, Wada N, Maeda H. | 07/13/2019 |
| RSPO2 is upregulated in Idiopathic pulmonary fibrosis. | R-Spondin-2 Is Upregulated in Idiopathic Pulmonary Fibrosis and Affects Fibroblast Behavior.
Munguía-Reyes A, Balderas-Martínez YI, Becerril C, Checa M, Ramírez R, Ortiz B, Meléndez-Zajgla J, Pardo A, Selman M. | 04/20/2019 |
| results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers | RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B. | 11/24/2018 |
| RSPO2 is a novel target gene of the NOBOX key transcription factor, confirming its important role during the follicular growth in ovary. However, RSPO2 mutations are rare or uncommon in women with primary ovarian insufficiency. | R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.
Bouilly J, Beau I, Barraud S, Bernard V, Delemer B, Young J, Binart N., Free PMC Article | 05/12/2018 |
| Novel targets ANTXR1 and RSPO2 were confirmed to be suppressed by miR-493 directly. | MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2).
Xu Y, Ge K, Lu J, Huang J, Wei W, Huang Q. | 04/28/2018 |
| RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway | RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.
Yin X, Yi H, Wang L, Wu W, Wu X, Yu L., Free PMC Article | 04/7/2018 |