| sites phosphorylated by CK2 overlap with active Orb and with Gurken protein expression. | Translational control of gurken mRNA in Drosophila development.
Derrick CJ, Weil TT., Free PMC Article | 06/24/2017 |
| The study suggests that both the localization and the translation of gurken mRNA in the vitellarium is independent from Vasa. | Combining the auxin-inducible degradation system with CRISPR/Cas9-based genome editing for the conditional depletion of endogenous Drosophila melanogaster proteins.
Bence M, Jankovics F, Lukácsovich T, Erdélyi M. | 06/24/2017 |
| The translational regulation of gurken protein in nurse cells, where the transcript is synthesized, occurs by a different mechanism from that of oskar protein and bicoid protein mRNA in the oocyte. | Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies.
Davidson A, Parton RM, Rabouille C, Weil TT, Davis I., Free PMC Article | 12/17/2016 |
| Localized cytoplasmic polyadenylation of grk mRNA by Wisp and Orb is necessary to achieve appropriate Grk protein accumulation in the D/A corner of the oocyte during mid to late oogenesis. | Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA.
Norvell A, Wong J, Randolph K, Thompson L. | 07/16/2016 |
| reducing the function of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expression | Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.
Li W, Klovstad M, Schüpbach T., Free PMC Article | 12/20/2014 |
| A new pathway is identified that mediates cell-type and branch-specific synaptic repulsion, a novel role for EGFR signaling in synaptic target selection, and an unexpected role for Gurken as a muscle-secreted repulsive ligand. | EGFR signaling modulates synaptic connectivity via Gurken.
Naylor SA, DiAntonio A., Free PMC Article | 06/8/2013 |
| The Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during dorsal-ventral patterning. | Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.
Tian AG, Tamori Y, Huang YC, Melendez NT, Deng WM., Free PMC Article | 02/23/2013 |
| Reduced TOR activity promotes grk translation independent of the canonical Vasa RNA helicase and cap-dependent mechanism. | Modulation of gurken translation by insulin and TOR signaling in Drosophila.
Ferguson SB, Blundon MA, Klovstad MS, Schüpbach T., Free PMC Article | 02/16/2013 |
| grk, a host gene encoding a crucial axis determinant, is a key component of an mRNP complex that regulates Wolbachia proliferation in Drosophila oogenesis. | A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer.
Serbus LR, Ferreccio A, Zhukova M, McMorris CL, Kiseleva E, Sullivan W., Free PMC Article | 07/7/2012 |
| Data indicate that trapping at the anterodorsal corner requires at least one as-yet-unidentified gurken RLE. | Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.
Lan L, Lin S, Zhang S, Cohen RS., Free PMC Article | 04/30/2011 |
| Bicaudal C and trailer hitch interact genetically. Mutants of these two genes have shared defects in localization of gurken and other anteriorly-localized mRNAs, as well as altered microtubule organization which may underlie the mRNA localization defects. | Bicaudal C and trailer hitch have similar roles in gurken mRNA localization and cytoskeletal organization.
Snee MJ, Macdonald PM., Free PMC Article | 01/21/2010 |
| Glycosphingolipids are necessary for full activation of the EGFR pathway during oogenesis in a time-dependent manner. | Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken.
Pizette S, Rabouille C, Cohen SM, Thérond P. | 01/21/2010 |
| Glorund is part of a complex containing the hnRNP protein Hrp48 and the splicing factor Half-pint and plays a role in gurken and oskar regulation. | Glorund interactions in the regulation of gurken and oskar mRNAs.
Kalifa Y, Armenti ST, Gavis ER., Free PMC Article | 01/21/2010 |
| Germline clones of mutant Sec61beta show normal translocation of Gurken into the ER and transport to the Golgi complex, but further traffic to the plasma membrane is impeded. The defect in plasma membrane traffic is specific for Gurken. | Sec61beta, a subunit of the Sec61 protein translocation channel at the endoplasmic reticulum, is involved in the transport of Gurken to the plasma membrane.
Kelkar A, Dobberstein B., Free PMC Article | 01/21/2010 |
| Data suggest that that Squid interacts with gurken mRNA in the nurse cell nuclei and, together with other factors, maintains gurken in a translationally silent state during its transport to the dorsal anterior region of the oocyte. | Translational repression of gurken mRNA in the Drosophila oocyte requires the hnRNP Squid in the nurse cells.
Cáceres L, Nilson LA. | 01/21/2010 |
| a mitotic cell cycle checkpoint may impinge on grk expression, much as meiotic checkpoints can alter expression of this gene | Identification of genes that influence gurken expression.
Geng C, Macdonald PM. | 01/21/2010 |
| Results show that Gurken travels towards the lateral/posterior of the egg chamber in the absence of Cbl, suggesting that Cbl actively regulates Gurken distribution through promoting endocytosis and subsequent degradation. | The gradient of Gurken, a long-range morphogen, is directly regulated by Cbl-mediated endocytosis.
Chang WL, Liou W, Pen HC, Chou HY, Chang YW, Li WH, Chiang W, Pai LM. | 01/21/2010 |
| Disrupting Dynein function disperses gurken mRNA homogeneously throughout the cytoplasm, whereas the loss of Squid function converts the sponge bodies into active transport particles. | Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies.
Delanoue R, Herpers B, Soetaert J, Davis I, Rabouille C. | 01/21/2010 |
| the cytoplasmic Dynein-light-chain (DDLC1) which is the cargo-binding subunit of the Dynein motor protein, directly bound with high specificity and affinity to a 230-nucleotide region within the 3'UTR of gurken | Drosophila Dynein light chain (DDLC1) binds to gurken mRNA and is required for its localization.
Rom I, Faicevici A, Almog O, Neuman-Silberberg FS. | 01/21/2010 |
| pipe repression depends on the TGFalpha-like ligand Gurken, which activates the Drosophila EGF receptor in dorsal follicle cells. | Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila.
Peri F, Technau M, Roth S. | 01/21/2010 |
| Bruno binds specifically to the gurken 3'UTR and that the dorso-ventral defects caused by Bruno over-expression are due to a reduction of Gurken levels in the oocyte, Bruno plays similar roles in translational regulation of gurken and oskar. | Bruno regulates gurken during Drosophila oogenesis.
Filardo P, Ephrussi A. | 01/21/2010 |
| study shows that the repression of bves expression in anterior-dorsal follicle cells is regulated by the Grk/EGFR signalling pathway. | Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling.
Lin S, Zhao D, Bownes M. | 01/21/2010 |
| Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte. | Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte.
Cáceres L, Nilson LA. | 01/21/2010 |
| The two steps of gurken RNA transport occur on distinct arrays of microtubules. Such microtubule networks could provide a mechanism for one motor to transport different cargos to distinct subcellular destinations. | Drosophila gurken (TGFalpha) mRNA localizes as particles that move within the oocyte in two dynein-dependent steps.
MacDougall N, Clark A, MacDougall E, Davis I. | 01/21/2010 |
| Star interaction with arrest results in excess Gurken protein, supporting the model that gurken is a target of repression. | Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.
Yan N, Macdonald PM., Free PMC Article | 01/21/2010 |