| Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila. | Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila.
Gonzalez LE, Tang X, Lin H., Free PMC Article | 08/26/2024 |
| Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster. | Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
Bence M, Jankovics F, Kristó I, Gyetvai Á, Vértessy BG, Erdélyi M. | 04/22/2024 |
| DNMT3L interacts with Piwi and modulates the expression of piRNAs in transgenic Drosophila. | DNMT3L interacts with Piwi and modulates the expression of piRNAs in transgenic Drosophila.
Rajeev R, Mishra RK, Khosla S. | 03/11/2024 |
| Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein. | Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
Yun HM, Hyun B, Song X, Hyun S. | 02/8/2024 |
| Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster. | Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster.
Yushkova E. | 01/29/2024 |
| Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells. | Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.
Onishi R, Sato K, Murano K, Negishi L, Siomi H, Siomi MC., Free PMC Article | 07/23/2022 |
| Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. | Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J. | 02/26/2022 |
| Complex Genetic Interactions between Piwi and HP1a in the Repression of Transposable Elements and Tissue-Specific Genes in the Ovarian Germline. | Complex Genetic Interactions between Piwi and HP1a in the Repression of Transposable Elements and Tissue-Specific Genes in the Ovarian Germline.
Ilyin AA, Stolyarenko AD, Zenkin N, Klenov MS., Free PMC Article | 01/15/2022 |
| Genome-wide mapping of Piwi association with specific loci in Drosophila ovaries. | Genome-wide mapping of Piwi association with specific loci in Drosophila ovaries.
Liu N, Neuenkirchen N, Zhong M, Lin H., Free PMC Article | 07/17/2021 |
| Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways. | Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways.
Gamez S, Srivastav S, Akbari OS, Lau NC., Free PMC Article | 06/19/2021 |
| Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation. | Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation.
Yamashiro H, Negishi M, Kinoshita T, Ishizu H, Ohtani H, Siomi MC., Free PMC Article | 05/8/2021 |
| Epigenetic Requirements for Triggering Heterochromatinization and Piwi-Interacting RNA Production from Transgenes in the Drosophila Germline. | Epigenetic Requirements for Triggering Heterochromatinization and Piwi-Interacting RNA Production from Transgenes in the Drosophila Germline.
Komarov PA, Sokolova O, Akulenko N, Brasset E, Jensen S, Kalmykova A., Free PMC Article | 03/13/2021 |
| Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries. | Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries.
Stolyarenko AD., Free PMC Article | 11/21/2020 |
| Dissociation of Piwi from nuage occurs at the depolymerizing microtubules of the central spindle, mediated by a microtubule-depolymerizing kinesin, Klp10A. Depletion of klp10A delays the return of Piwi to the nucleus and affects piRNA production, suggesting the role of nuclear-cytoplasmic communication in piRNA biogenesis. | A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuage.
Venkei ZG, Choi CP, Feng S, Chen C, Jacobsen SE, Kim JK, Yamashita YM., Free PMC Article | 07/25/2020 |
| PIWI-clade Argonaute proteins associate with PIWI-interacting RNAs (piRNAs), and silence transposons in animal gonads. Drosophila PIWI-clade Argonaute Piwi in complex with endogenous piRNAs, at 2.9 A resolution. A structural comparison of Piwi with other Argonautes highlights the PIWI-specific structural features, such as the overall domain arrangement and metal-dependent piRNA recognition. | Crystal structure of Drosophila Piwi.
Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O., Free PMC Article | 04/25/2020 |
| Piwi autoregulates its nuclear localization by exposing the nuclear localization signal to Impalpha upon piRNA loading. | Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells.
Yashiro R, Murota Y, Nishida KM, Yamashiro H, Fujii K, Ogai A, Yamanaka S, Negishi L, Siomi H, Siomi MC. | 12/14/2019 |
| The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and transposable elements silencing. | The interplay between the Argonaute proteins Piwi and Aub within Drosophila germarium is critical for oogenesis, piRNA biogenesis and TE silencing.
Théron E, Maupetit-Mehouas S, Pouchin P, Baudet L, Brasset E, Vaury C., Free PMC Article | 06/29/2019 |
| our data identify heterochromatin decondensation, piwi and piRNA depletion and consequent transposable element dysregulation as a pharmacologically targetable, mechanistic driver of neurodegeneration in tauopathy | Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.
Sun W, Samimi H, Gamez M, Zare H, Frost B., Free PMC Article | 05/11/2019 |
| The role of PIWI specificity domain in the interactions with piRNA. | Decoding the 5' nucleotide bias of PIWI-interacting RNAs.
Stein CB, Genzor P, Mitra S, Elchert AR, Ipsaro JJ, Benner L, Sobti S, Su Y, Hammell M, Joshua-Tor L, Haase AD., Free PMC Article | 04/13/2019 |
| PAF1 knockdown enhances PIWI silencing of reporters when Piwi-interacting RNAs (piRNAs)-target the transcript region proximal to the promoter. Loss of PAF1 suppresses endogenous transposable element (TE) transcript maturation, whereas a subset of gene transcripts and long-non-coding RNAs adjacent to TE insertions are affected by PAF1 knockdown in a similar fashion to piRNA-targeted reporters. | Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity.
Clark JP, Rahman R, Yang N, Yang LH, Lau NC., Free PMC Article | 07/28/2018 |
| These data identify a role for Piwi in the regulation of somatic stem cell function. | Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells.
Sousa-Victor P, Ayyaz A, Hayashi R, Qi Y, Madden DT, Lunyak VV, Jasper H., Free PMC Article | 05/19/2018 |
| Data show that Cbp80 knockdown not only led to the upregulation of transposons, but also to delocalization of Piwi, Aub and Ago3, key factors in the piRNA biosynthesis pathway. | Cbp80 is needed for the expression of piRNA components and piRNAs.
Rashpa R, Vazquez-Pianzola P, Colombo M, Hernandez G, Beuchle D, Berger F, Peischl S, Bruggmann R, Suter B., Free PMC Article | 10/28/2017 |
| Report the mapping of multiple Piwi-interacting chromosomal domains in somatic cells of ovaries. These domains significantly overlap with genomic regions tethered to Nuclear Pore Complexes. | Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells.
Ilyin AA, Ryazansky SS, Doronin SA, Olenkina OM, Mikhaleva EA, Yakushev EY, Abramov YA, Belyakin SN, Ivankin AV, Pindyurin AV, Gvozdev VA, Klenov MS, Shevelyov YY., Free PMC Article | 10/14/2017 |
| The identity of piRNA clusters is epigenetically acquired in a Piwi-dependent manner during embryonic development. | Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult Ovaries.
Akkouche A, Mugat B, Barckmann B, Varela-Chavez C, Li B, Raffel R, Pélisson A, Chambeyron S. | 09/9/2017 |
| Piwi-piRNA complexes regulate the interaction of chromatin components with target loci to maintain silencing of transposable elements through the modulation of chromatin accessibility. | Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K. | 09/2/2017 |