| Evidence of Adaptive Evolution in Wolbachia-Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking. | Evidence of Adaptive Evolution in Wolbachia-Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking.
Bhattacharya T, Rice DW, Crawford JM, Hardy RW, Newton ILG., Free PMC Article | 02/5/2022 |
| mutations in two (cytosine-5) RNA methyltransferases, Dnmt2 and NSun2, impact the accumulation of mobile element-derived sequences and DNA repeat integrity in Drosophila. | Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.
Genenncher B, Durdevic Z, Hanna K, Zinkl D, Mobin MB, Senturk N, Da Silva B, Legrand C, Carré C, Lyko F, Schaefer M. | 06/8/2019 |
| Wolbachia elevates D. melanogaster Mt2 expression to block Sindbis virus infection. | Wolbachia elevates host methyltransferase expression to block an RNA virus early during infection.
Bhattacharya T, Newton ILG, Hardy RW., Free PMC Article | 09/23/2017 |
| The differences found in the electrostatic potentials may be linked with different affinities and processivity of DNMT2 for its different substrates (DNA, RNA or tRNA) and even for interactions with other proteins involved in the epigenetic mechanisms | Linking epigenetic function to electrostatics: The DNMT2 structural model example.
Vieira GC, Vieira GF, Sinigaglia M, Silva Valente VLD., Free PMC Article | 09/23/2017 |
| Mt2, the fly's only candidate DNA methyltransferase, is not necessary for the observed DNA methylation. | Now you see it: genome methylation makes a comeback in Drosophila.
Boffelli D, Takayama S, Martin DI. | 08/29/2015 |
| No difference was detected in recombination rates between Dnmt2 -/- and Dnmt2 +/- flies in two euchromatic regions and one heterochromatic region across the genome. | No detectable effect of the DNA methyltransferase DNMT2 on Drosophila meiotic recombination.
Heil CS., Free PMC Article | 07/25/2015 |
| Though the genome of Drosophila is essentially unmethylated, it contains a 5-methylcytosine oxidase. | The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: possible explanations.
Dunwell TL, McGuffin LJ, Dunwell JM, Pfeifer GP., Free PMC Article | 06/7/2014 |
| Dnmt2 mutant flies accumulate increasing levels of Drosophila C virus and show activated innate immune responses. | Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.
Durdevic Z, Hanna K, Gold B, Pollex T, Cherry S, Lyko F, Schaefer M., Free PMC Article | 08/31/2013 |
| Dnmt2-dependent methylomes lack defined DNA methylation patterns. | Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F., Free PMC Article | 08/10/2013 |
| ytosine-5 methyltransferase DNMT2 controls retrotransposon silencing in Drosophila somatic cells. | Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2.
Phalke S, Nickel O, Walluscheck D, Hortig F, Onorati MC, Reuter G. | 11/6/2010 |
| in addition to tRNA(Asp-GTC), tRNA(Val-AAC) and tRNA(Gly-GCC) are also methylated by Dnmt2 | RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F., Free PMC Article | 08/23/2010 |
| Dnmt2-EGFP enters prophase nuclei and shows a spindle-like localization pattern during mitotic divisions. Additional experiments suggest that this localization is microtubule dependent and that Dnmt2 can access DNA during mitotic cell divisions | The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis.
Schaefer M, Steringer JP, Lyko F., Free PMC Article | 01/21/2010 |
| The data support a model in which the activation of heat shock factor normally found as an inactive monomer bound to chaperones is linked to the overexpressed C-terminus of dDnmt2 isoform C. | Overexpressed Drosophila DNA methyltransferase 2 isoform C interacts with Hsp70 in vivo.
Roder K. | 01/21/2010 |
| These results demonstrate that Dnmt2 is both necessary and sufficient for DNA methylation in Drosophila and suggest a novel CpT/A-specific DNA methyltransferase activity for Dnmt2 proteins. | A Dnmt2-like protein mediates DNA methylation in Drosophila.
Kunert N, Marhold J, Stanke J, Stach D, Lyko F. | 01/21/2010 |
| DNMT2 gene products are genuine cytosine-5 DNA methyltransferases | The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferases.
Tang LY, Reddy MN, Rasheva V, Lee TL, Lin MJ, Hung MS, Shen CK. | 01/21/2010 |
| required for maintenance of the normal life span of the fruit flies | DNA methyltransferase gene dDnmt2 and longevity of Drosophila.
Lin MJ, Tang LY, Reddy MN, Shen CK. | 01/21/2010 |