| A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1. | A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1.
Palu RAS, Owings KG, Garces JG, Nicol A., Free PMC Article | 06/11/2022 |
| The activation of cardiac dSir2-related pathways mediates physical exercise resistance to heart aging in old Drosophila. | The activation of cardiac dSir2-related pathways mediates physical exercise resistance to heart aging in old Drosophila.
Wen DT, Zheng L, Li JX, Lu K, Hou WQ., Free PMC Article | 09/5/2020 |
| Sirt1 terminates ethanol-induction of Hr38 to promote ethanol tolerance. | Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.
Adhikari P, Orozco D, Randhawa H, Wolf FW., Free PMC Article | 05/4/2019 |
| Sir2 in the mushroom bodies promotes short-term ethanol-induced behavioral plasticity by allowing changes in the expression of presynaptic molecules. | Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward.
Engel GL, Marella S, Kaun KR, Wu J, Adhikari P, Kong EC, Wolf FW., Free PMC Article | 07/1/2017 |
| The role of Sirt1 in Notch signalling is, therefore, more complex than previously recognized, and its diverse effects may be explained by a plethora of Sirt1 substrates involved in the regulation of Notch signalling. | The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila.
Horvath M, Mihajlovic Z, Slaninova V, Perez-Gomez R, Moshkin Y, Krejci A. | 06/24/2017 |
| A lowered gene dosage of Sir2, in mutant heterozygotes, can extend normal longevity and greatly augment survivorship during amino-acid starvation in Drosophila. | Extended longevity and survivorship during amino-acid starvation in a Drosophila Sir2 mutant heterozygote.
Slade JD, Staveley BE. | 03/25/2017 |
| Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions. | Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
Palu RA, Thummel CS., Free PMC Article | 08/20/2016 |
| Low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes. | [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
Berezovs'kyĭ VIa, Chaka OH, Litovka IH, Levashov MI, Ianko RV. | 12/20/2014 |
| Using two transgenic dSir2 lines that were reported not to extend life span, we show significant life span extension when dSir2 expression is induced between 2 and 5-fold. | Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner.
Whitaker R, Faulkner S, Miyokawa R, Burhenn L, Henriksen M, Wood JG, Helfand SL., Free PMC Article | 06/7/2014 |
| This study provides additional independent evidence for the concept of Sir2 as a longevity gene and as a promising pharmacological target to cure age-related diseases. | Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila.
Hoffmann J, Romey R, Fink C, Yong L, Roeder T., Free PMC Article | 10/26/2013 |
| dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. | dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.
Banerjee KK, Ayyub C, Ali SZ, Mandot V, Prasad NG, Kolthur-Seetharam U. | 06/8/2013 |
| Muscle dSir2 regulates mitochondrial functions and energy homeostasis autonomously and mimics the nonautonomous effects of fat body dSir2. | Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.
Banerjee KK, Ayyub C, Sengupta S, Kolthur-Seetharam U., Free PMC Article | 02/23/2013 |
| Polo-mediated phosphorylation of Maelstrom may be a mechanism that controls oocyte determination by inactivating the pachytene checkpoint via the repression of Sir2 in Drosophila ovaries. | Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila.
Pek JW, Ng BF, Kai T. | 02/2/2013 |
| Report delineates the functions of dSir2 in the fatbody and muscles with systemic consequences on fat metabolism and insulin signaling. | dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies.
Banerjee KK, Ayyub C, Sengupta S, Kolthur-Seetharam U., Free PMC Article | 08/25/2012 |
| These results strongly support the role of Sir2 and FOXO in preventing mitochondrial dysfunction and DA neuron loss, further suggesting that Sir2 and FOXO function downstream of PINK1 and independently of Parkin. | Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant.
Koh H, Kim H, Kim MJ, Park J, Lee HJ, Chung J., Free PMC Article | 06/23/2012 |
| tetrahydrocurcumin may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2. | Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor.
Xiang L, Nakamura Y, Lim YM, Yamasaki Y, Kurokawa-Nose Y, Maruyama W, Osawa T, Matsuura A, Motoyama N, Tsuda L., Free PMC Article | 04/7/2012 |
| negative findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila | Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D., Free PMC Article | 11/5/2011 |
| Evidence in Drosophila implicates Sir2 in at least some of the beneficial effects of caloric restriction | dSir2 and longevity in Drosophila.
Frankel S, Ziafazeli T, Rogina B., Free PMC Article | 08/20/2011 |
| These findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet. | A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability.
Reis T, Van Gilst MR, Hariharan IK., Free PMC Article | 03/5/2011 |
| Dmp53 is a down stream target of dSir2 enzymatic activity and mediates some aspects of the life span extending effects of caloric restriction. | dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.
Bauer JH, Morris SN, Chang C, Flatt T, Wood JG, Helfand SL., Free PMC Article | 07/19/2010 |
| In Drosophila, spontaneous physical activity closely mimics life span in its dependence on Sir2. | dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction.
Parashar V, Rogina B., Free PMC Article | 06/28/2010 |
| Huntington's disease in Drosophila model is most readily impacted by inhibition of Rpd3 and Sir2 either individually or in combination. | Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.
Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL., Free PMC Article | 01/21/2010 |
| Sir2 normally participates in the regulation of cell survival and death in Drosophila. | Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila.
Griswold AJ, Chang KT, Runko AP, Knight MA, Min KT., Free PMC Article | 01/21/2010 |
| role in histone deacetylation generates a transcriptionally repressed nucleoprotein complex | Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.
Parsons XH, Garcia SN, Pillus L, Kadonaga JT., Free PMC Article | 01/21/2010 |
| modifies position-effect variegation but does not affect life span | A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span.
Newman BL, Lundblad JR, Chen Y, Smolik SM., Free PMC Article | 01/21/2010 |