| Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos. | Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos.
Hu T, Li C, Qiao S, Liu W, Han W, Li W, Shi R, Xue X, Shi J, Huang G, Lin T., Free PMC Article | 11/29/2023 |
| TUBB8 mutations as a cause of oocyte maturation abnormalities: presentation of oocyte and embryo profiles and novel mutations. | TUBB8 mutations as a cause of oocyte maturation abnormalities: presentation of oocyte and embryo profiles and novel mutations.
Ebru H, Dahan MH, Sezer O, Başbuğ A, Kaan H, Güngör ND, Baltacı V, Tan SL, Şafak H. | 11/15/2023 |
| Phenotypic variability in two female siblings with oocyte maturation arrest due to a TUBB8 variant. | Phenotypic variability in two female siblings with oocyte maturation arrest due to a TUBB8 variant.
Dou Q, Xu H, Ma L, Tan L, Tang W., Free PMC Article | 11/1/2023 |
| Evaluation of TUBB8 gene alterations in infertile women with oocyte maturation and cleavage arrest referred to Royan Institute. | Evaluation of TUBB8 gene alterations in infertile women with oocyte maturation and cleavage arrest referred to Royan Institute.
Boroujeni PB, Rooney K, Alikhani M, Rahmati S, Feli G, Haratian K, Movaghar B, Meybodi AM. | 09/20/2023 |
| A novel compound heterozygous mutation in TUBB8 causing early embryonic developmental arrest. | A novel compound heterozygous mutation in TUBB8 causing early embryonic developmental arrest.
Zhang J, Li S, Huang F, Xu R, Wang D, Song T, Liang B, Liu D, Chen J, Shi X, Huang HL., Free PMC Article | 05/30/2023 |
| Genetic screening and analysis of TUBB8 variants in females seeking ART. | Genetic screening and analysis of TUBB8 variants in females seeking ART.
Lin T, Liu W, Han W, Tong K, Xiang Y, Liao H, Chen K, He Y, Liu D, Huang G. | 02/10/2023 |
| Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility. | Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility.
Li W, Li Q, Xu X, Wang C, Hu K, Xu J. | 12/3/2022 |
| Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest. | Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest.
Yao Z, Zeng J, Zhu H, Zhao J, Wang X, Xia Q, Li Y, Wu L., Free PMC Article | 04/9/2022 |
| Expanding the Genetic and Phenotypic Spectrum of Female Infertility Caused by TUBB8 Mutations. | Expanding the Genetic and Phenotypic Spectrum of Female Infertility Caused by TUBB8 Mutations.
Lu Q, Zhang X, Cao Q, Wang C, Ding J, Zhao C, Zhang J, Ling X, Meng Q, Huo R, Li H. | 03/12/2022 |
| TUBB8 Mutations Cause Female Infertility with Large Polar Body Oocyte and Fertilization Failure. | TUBB8 Mutations Cause Female Infertility with Large Polar Body Oocyte and Fertilization Failure.
Liu Z, Xi Q, Zhu L, Yang X, Jin L, Wang J, Zhang T, Zhou X, Zhang D, Peng X, Luo Y, Li Z, Zhang X. | 03/5/2022 |
| Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos. | Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos.
Cao T, Guo J, Xu Y, Lin X, Deng W, Cheng L, Zhao H, Jiang S, Gao M, Huang J, Xu Y. | 02/26/2022 |
| The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility. | The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility.
Zheng W, Hu H, Zhang S, Xu X, Gao Y, Gong F, Lu G, Lin G., Free PMC Article | 02/5/2022 |
| Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects. | Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects.
Yang P, Yin C, Li M, Ma S, Cao Y, Zhang C, Chen T, Zhao H. | 10/2/2021 |
| Oocyte maturation arrest produced by TUBB8 mutations: impact of genetic disorders in infertility treatment. | Oocyte maturation arrest produced by TUBB8 mutations: impact of genetic disorders in infertility treatment.
Lanuza-López MC, Martínez-Garza SG, Solórzano-Vázquez JF, Paz-Cervantes D, González-Ortega C, Maldonado-Rosas I, Villegas-Moreno G, Villar-Muñoz LG, Arroyo-Méndez FA, Gutiérrez-Gutiérrez AM, Piña-Aguilar RE. | 08/21/2021 |
| Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility. | Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility.
Jia Y, Li K, Zheng C, Tang Y, Bai D, Yin J, Chi F, Zhang Y, Li Y, Tu Z, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kong P, Wu B, Hu Y, Wang H, Liu W, Teng X, Gao S., Free PMC Article | 06/5/2021 |
| Identification novel mutations in TUBB8 in female infertility and a novel phenotype of large polar body in oocytes with TUBB8 mutations. | Identification novel mutations in TUBB8 in female infertility and a novel phenotype of large polar body in oocytes with TUBB8 mutations.
Zhao L, Guan Y, Wang W, Chen B, Xu S, Wu L, Yan Z, Li B, Fu J, Shi R, Shi J, Du J, Li Q, Zhang Z, Mu J, Zhou Z, Dong J, Jin L, He L, Sun X, Kuang Y, Wang L, Sang Q., Free PMC Article | 05/8/2021 |
| Novel mutations in TUBB8 expand the mutational and phenotypic spectrum of patients with zygotes containing multiple pronuclei. | Novel mutations in TUBB8 expand the mutational and phenotypic spectrum of patients with zygotes containing multiple pronuclei.
Sha Q, Zheng W, Feng X, Yuan R, Hu H, Gong F, Hu L, Lin G, Ou X. | 02/2/2021 |
| TUBB8 mutations cause oocyte maturation arrest, fertilization failure, early embryonic arrest and embryo implantation failure. | The comprehensive mutational and phenotypic spectrum of TUBB8 in female infertility.
Chen B, Wang W, Peng X, Jiang H, Zhang S, Li D, Li B, Fu J, Kuang Y, Sun X, Wang X, Zhang Z, Wu L, Zhou Z, Lyu Q, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Sang Q, Wang L., Free PMC Article | 05/11/2019 |
| A novel missense TUBB8 mutation (c.1054G > T, p.A352S) in the patient and her elder sister was detected and shown to be associated with oocyte maturation arrest as the cause for their infertility. | Human oocyte maturation arrest caused by a novel missense mutation in TUBB8.
Xiang J, Wang W, Qian C, Xue J, Wang T, Li H, Li H., Free PMC Article | 03/30/2019 |
| This TUBB8 variant in one infertile individual was absent in the 100 fertile females and was predicted to be highly damaging to the function of the TUBB8 protein by SIFT and PolyPhen-2. | Mutation analysis of the TUBB8 gene in primary infertile women with arrest in oocyte maturation.
Wang AC, Zhang YS, Wang BS, Zhao XY, Wu FX, Zhai XH, Sun JX, Mei SY. | 12/22/2018 |
| A homozygous mutation of TUBB8 associated with complete cleavage failure in fertilized eggs. | A novel mutation in the TUBB8 gene is associated with complete cleavage failure in fertilized eggs.
Yuan P, Zheng L, Liang H, Li Y, Zhao H, Li R, Lai L, Zhang Q, Wang W., Free PMC Article | 11/3/2018 |
| TUBB8 mutations occur in a high proportion of infertile women with oocyte maturation arrest. | Mutation analysis of the TUBB8 gene in nine infertile women with oocyte maturation arrest.
Huang L, Tong X, Luo L, Zheng S, Jin R, Fu Y, Zhou G, Li D, Liu Y. | 05/5/2018 |
| The results not only emphasize the important role of TUBB8 in oocyte maturation, fertilization and early embryonic development but they also provide a basis for determining the genetic variations in TUBB8 as a potential additional criterion for evaluating the quality of patients' functional PB1 oocytes. | Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development.
Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y, Sang Q, Wang L. | 02/24/2018 |
| 9 novel TUBB8 mutations and phenotypes in patients with oocyte maturation arrest were reported. | Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos.
Feng R, Yan Z, Li B, Yu M, Sang Q, Tian G, Xu Y, Chen B, Qu R, Sun Z, Sun X, Jin L, He L, Kuang Y, Cowan NJ, Wang L., Free PMC Article | 08/26/2017 |
| TUBB8 mutations have dominant-negative effects that disrupt microtubule behavior and oocyte meiotic spindle assembly and maturation, causing female infertility. | Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ, Wang L., Free PMC Article | 05/7/2016 |