| Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis. | Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
Ryan SM, Almassey M, Burch AM, Ngo G, Martin JM, Myers D, Compton D, Archie S, Cross M, Naeger L, Salzman A, Virola-Iarussi A, Barbee SA, Mortimer NT, Sanyal S, Vrailas-Mortimer AD., Free PMC Article | 02/26/2022 |
| Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration. | Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Esteban-Collado J, Corominas M, Serras F. | 09/25/2021 |
| Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila. | Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila.
Ryan SM, Wildman K, Oceguera-Perez B, Barbee S, Mortimer NT, Vrailas-Mortimer AD., Free PMC Article | 05/29/2021 |
| These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms. | A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.
Terriente-Félix A, Pérez L, Bray SJ, Nebreda AR, Milán M., Free PMC Article | 12/9/2017 |
| ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration. | ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration.
Santabárbara-Ruiz P, López-Santillán M, Martínez-Rodríguez I, Binagui-Casas A, Pérez L, Milán M, Corominas M, Serras F., Free PMC Article | 06/4/2016 |
| Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways. | The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.
Dusik V, Senthilan PR, Mentzel B, Hartlieb H, Wülbeck C, Yoshii T, Raabe T, Helfrich-Förster C., Free PMC Article | 11/7/2015 |
| data suggest that p38Kb may affect circadian locomotor rhythms through the regulation of multiple downstream pathways | p38 MAP kinase regulates circadian rhythms in Drosophila.
Vrailas-Mortimer AD, Ryan SM, Avey MJ, Mortimer NT, Dowse H, Sanyal S. | 07/25/2015 |
| Data show that the genetic interaction between p38b MAPK and Rack1 controls muscle aggregate formation, locomotor function, and longevity. | In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.
Belozerov VE, Ratkovic S, McNeill H, Hilliker AJ, McDermott JC., Free PMC Article | 03/22/2014 |
| The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis. | Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.
Wongtrakul J, Sukittikul S, Saisawang C, Ketterman AJ., Free PMC Article | 07/27/2013 |
| found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles | High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.
Belozerov VE, Lin ZY, Gingras AC, McDermott JC, Michael Siu KW., Free PMC Article | 11/24/2012 |
| Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity. | A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.
Vrailas-Mortimer A, del Rivero T, Mukherjee S, Nag S, Gaitanidis A, Kadas D, Consoulas C, Duttaroy A, Sanyal S., Free PMC Article | 12/17/2011 |
| The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection. | Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.
Chen J, Xie C, Tian L, Hong L, Wu X, Han J., Free PMC Article | 01/8/2011 |
| p38b MAPK plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut. | The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila.
Park JS, Kim YS, Yoo MA., Free PMC Article | 08/30/2010 |
| the D-p38b gene is regulated by the DREF pathway and DREF is involved in the regulation of proliferation and differentiation of Drosophila ISCs and progenitors | Regulation of the Drosophila p38b gene by transcription factor DREF in the adult midgut.
Park JS, Kim YS, Kim JG, Lee SH, Park SY, Yamaguchi M, Yoo MA. | 08/16/2010 |