| Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy. | Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy.
Huang Y, Sun X, Nie G, Xu H, Zou M. | 08/22/2024 |
| Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV). | Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV).
Held M, Kozmar A, Sestan M, Turudic D, Kifer N, Srsen S, Gagro A, Frkovic M, Jelusic M., Free PMC Article | 05/7/2024 |
| The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy. | The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy.
Tian H, Zhai Y, Sun S, Zhang W, Zhao Z., Free PMC Article | 04/22/2024 |
| Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy. | Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.
Ito S, Misaki T, Nagasawa Y, Nomura R, Naka S, Fukunaga A, Matsuoka D, Matayoshi S, Matsumoto-Nakano M, Nakano K. | 02/22/2024 |
| Galactose-deficient IgA1 Is Involved in IgA Deposition in Renal Grafts Biopsied One Hour after Kidney Transplantation. | Galactose-deficient IgA1 Is Involved in IgA Deposition in Renal Grafts Biopsied One Hour after Kidney Transplantation.
Kuroyanagi Y, Takeda A, Kinashi H, Kuroyanagi Y, Murata M, Futamura K, Goto N, Watarai Y, Ishimoto T, Morozumi K, Ito Y., Free PMC Article | 06/2/2023 |
| Aberrant RL2 O-GlcNAc antibody reactivity against serum-IgA1 of patients with colorectal cancer. | Aberrant RL2 O-GlcNAc antibody reactivity against serum-IgA1 of patients with colorectal cancer.
Verathamjamras C, Sriwitool TE, Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Prasongsook N, Srisomsap C, Svasti J, Champattanachai V. | 01/29/2022 |
| CD71 mesangial IgA1 receptor and the progression of IgA nephropathy. | CD71 mesangial IgA1 receptor and the progression of IgA nephropathy.
Jhee JH, Nam BY, Park JT, Kim HW, Chang TI, Kang EW, Lim BJ, Yoo TH, Kang SW, Jeong HJ, Han SH. | 08/14/2021 |
| Elevated Endostatin Expression Is Regulated by the pIgA Immune Complex and Associated with Disease Severity of IgA Nephropathy. | Elevated Endostatin Expression Is Regulated by the pIgA Immune Complex and Associated with Disease Severity of IgA Nephropathy.
Zhai Y, Long X, Gao J, Yao X, Wang X, Zhao Z. | 06/12/2021 |
| TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy. | TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy.
Zheng N, Xie K, Ye H, Dong Y, Wang B, Luo N, Fan J, Tan J, Chen W, Yu X., Free PMC Article | 05/22/2021 |
| Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma. | Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma.
Kawata Y, Hirano H, Takahashi R, Miyano Y, Kimura A, Sato N, Morita Y, Kimura H, Fujita K., Free PMC Article | 04/24/2021 |
| is s immune component extensively expressed in mucosa and epidermis, which are responsible for the first line of host defense. | Influence of chewing on expression level of human beta-defensin 2 and secretory immunoglobulin A in the epithelium.
Ishida A, Wada T, Ogami K, Ueda T, Sakurai K. | 08/10/2019 |
| Although IgAN and HSPN remain difficult to differentiate, s-Gd-IgA1 elevation and m-Gd-IgA1 deposition are reliable diagnostic factors that reflect IgAN severity. Serum-Gd-IgA1 could serve as a predictor of renal outcomes in IgAN. Thus, Gd-IgA1 could be significant biomarker for patients with IgAN | Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.
Wada Y, Matsumoto K, Suzuki T, Saito T, Kanazawa N, Tachibana S, Iseri K, Sugiyama M, Iyoda M, Shibata T., Free PMC Article | 04/13/2019 |
| IL-17 might participate in IgA nephropathy pathogenesis by influencing the production and glycosylation of IgA1 in B-cells. | Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells.
Lin JR, Wen J, Zhang H, Wang L, Gou FF, Yang M, Fan JM., Free PMC Article | 08/11/2018 |
| The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc. | TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc.
Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, Chen Q. | 05/20/2017 |
| In IgA nephropathy, increased APRIL is accompanied by elevated expression of its receptors in B-lymphocytes, which induces overproduction of galactose-deficient-IgA1. | Increased APRIL Expression Induces IgA1 Aberrant Glycosylation in IgA Nephropathy.
Zhai YL, Zhu L, Shi SF, Liu LJ, Lv JC, Zhang H., Free PMC Article | 08/6/2016 |
| hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1 | DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy.
Sun Q, Zhang J, Zhou N, Liu X, Shen Y., Free PMC Article | 01/16/2016 |
| The lower content of secretory immunoglobulin A and interferon-gamma plus increased level of interleukin l-beta in saliva of patients with caries of contact surfaces of lateral teeth can be considered as factor predisposing to development of caries. | [THE IMMUNOLOGIC INDICATORS IN PATIENTS WITH CARIES OF CONTACT SURFACES OF LATERAL TEETH].
Heigetyan AV, Bragin EA, Maksiukov SY, Labushkina AV, Alutina EL, Harseeva GG. | 12/12/2015 |
| The study developed a new model for sugar-specific sialylation of IgA1 O-glycans and showed that GalNAc recognition by Helix aspersa lectin is modulated by sialylation of not only GalNAc but also of Gal in the clustered IgA1 O-glycans. | Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy.
Takahashi K, Raska M, Stuchlova Horynova M, Hall SD, Poulsen K, Kilian M, Hiki Y, Yuzawa Y, Moldoveanu Z, Julian BA, Renfrow MB, Novak J., Free PMC Article | 10/10/2015 |
| Complement activation plays a key role in the pathogenesis and IGAN expression in patients diagnosed with IGA nephropathy. | Current Understanding of the Role of Complement in IgA Nephropathy.
Maillard N, Wyatt RJ, Julian BA, Kiryluk K, Gharavi A, Fremeaux-Bacchi V, Novak J., Free PMC Article | 09/12/2015 |
| The heritability of IgA levels is moderate and can partly be attributable to common variation in the CD30L locus. | IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.
Viktorin A, Frankowiack M, Padyukov L, Chang Z, Melén E, Sääf A, Kull I, Klareskog L, Hammarström L, Magnusson PK., Free PMC Article | 02/21/2015 |
| Serum under-O-glycosylated IgA1 levels are not correlated with glomerular IgA deposition based upon heterogeneity in the composition of glomerular immune complexes in IgAN patients. | Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y., Free PMC Article | 12/20/2014 |
| The palatine tonsils are probably a major site of galactose-deficient IgA1-producing cells. | Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy.
Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y., Free PMC Article | 11/8/2014 |
| In breast cancer, elevated levels of antibodies recognizing aberrant MUC1 are associated with better outcome, whereas in IgA nephropathy, the antibodies recognizing aberrant IgA1 are part of the pathogenetic process. [review] | Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma.
Stuchlová Horynová M, Raška M, Clausen H, Novak J., Free PMC Article | 04/6/2013 |
| Gal-deficient IgA1 might be inherited in Chinese patients with immunoglobulin A nephropathy | Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy.
Lin X, Ding J, Zhu L, Shi S, Jiang L, Zhao M, Zhang H. | 03/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration.
Giambra V, Cianci R, Lolli S, Mattioli C, Tampella G, Cattalini M, Kilic SS, Pandolfi F, Plebani A, Frezza D. | 01/20/2010 |