| Generation and timing of graded responses to morphogen gradients. | Generation and timing of graded responses to morphogen gradients.
Carmon S, Jonas F, Barkai N, Schejter ED, Shilo BZ., Free PMC Article | 02/12/2022 |
| Drosophila ELYS regulates Dorsal dynamics during development. | Drosophila ELYS regulates Dorsal dynamics during development.
Mehta SJK, Kumar V, Mishra RK., Free PMC Article | 10/24/2020 |
| Notch-responsive enhancers are activated synchronously in Drosophila embryos; Priming by Twist and Dorsal promotes fast and sustained response to Notch | Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling.
Falo-Sanjuan J, Lammers NC, Garcia HG, Bray SJ., Free PMC Article | 05/16/2020 |
| These results suggest that synergistic interactions between Dl and Zld and between DI and Bcd are required for broad sog expression. | The short gastrulation shadow enhancer employs dual modes of transcriptional synergy.
Shin DH, Hong JW. | 02/24/2018 |
| Dorsal, a Drosophila homolog of NF-kappaB, patterns the dorsal-ventral axis in the blastoderm embryo. During this stage, Dorsal is sequestered outside the nucleus by the IkappaB homolog Cactus. Dorsal accumulates on the ventral side of the syncytial blastoderm. We use modeling and experimental studies to show that this accumulation is caused by facilitated diffusion, or shuttling, of the Dorsal/Cactus complex. | A facilitated diffusion mechanism establishes the Drosophila Dorsal gradient.
Carrell SN, O'Connell MD, Jacobsen T, Pomeroy AE, Hayes SM, Reeves GT. | 12/9/2017 |
| ere, we describe an extensive, quantitative perturbation analysis targeting the dorsal-ventral patterning gene regulatory network (GRN) controlled by Drosophila NF-kappaB homolog Dorsal. | Quantitative perturbation-based analysis of gene expression predicts enhancer activity in early Drosophila embryo.
Sayal R, Dresch JM, Pushel I, Taylor BR, Arnosti DN., Free PMC Article | 11/25/2017 |
| It has been shown that Dorsal repressed Ush expression levels to promote hemocytes differentiation, whereas Cactus maintained Ush levels to block differentiation. | The Friend of GATA Transcriptional Co-Regulator, U-Shaped, Is a Downstream Antagonist of Dorsal-Driven Prohemocyte Differentiation in Drosophila.
Gao H, Baldeosingh R, Wu X, Fossett N., Free PMC Article | 07/8/2017 |
| There is a clear positive correlation between the number of Zld binding sites and the spatial domain of enhancer activity. Zld facilitates binding of Dl to regulatory DNA, and this is associated with increased chromatin accessibility. | Zelda potentiates morphogen activity by increasing chromatin accessibility.
Foo SM, Sun Y, Lim B, Ziukaite R, O'Brien K, Nien CY, Kirov N, Shvartsman SY, Rushlow CA., Free PMC Article | 02/27/2016 |
| The Toll-dorsal pathway is required for resistance to viral oral infection in Drosophila. | The Toll-dorsal pathway is required for resistance to viral oral infection in Drosophila.
Ferreira ÁG, Naylor H, Esteves SS, Pais IS, Martins NE, Teixeira L., Free PMC Article | 11/7/2015 |
| demonstrated that the core promoter composition is an important determinant of transcriptional activity of Dorsal target genes | Core promoter functions in the regulation of gene expression of Drosophila dorsal target genes.
Zehavi Y, Kuznetsov O, Ovadia-Shochat A, Juven-Gershon T., Free PMC Article | 06/28/2014 |
| Combinatorial effects of uniform and graded factors play an important role in the transcriptional and signaling cascades initiated by Dorsal and may explain differential positioning of gene expression borders by other morphogen gradients | Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient.
Rushlow CA, Shvartsman SY. | 07/13/2013 |
| via relief of Groucho- and Capicua-mediated repression, the Torso and EGFR RTK pathways induce expression of WntD, which in turn limits Dl nuclear localization at the poles and along the DV axis | RTK signaling modulates the Dorsal gradient.
Helman A, Lim B, Andreu MJ, Kim Y, Shestkin T, Lu H, Jiménez G, Shvartsman SY, Paroush Z., Free PMC Article | 10/20/2012 |
| we have compared genome occupancy of CBP with 40 different transcription factors in Drosophila embryos and find that master regulators of dorsal-ventral patterning, the transcription factors Dorsal and Medea, target CBP to the genome | Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos.
Holmqvist PH, Boija A, Philip P, Crona F, Stenberg P, Mannervik M., Free PMC Article | 09/29/2012 |
| Injury to the Drosophila larval central nervous system induces glial proliferation, and a gene network controlling this response consists of the mutual maintenance between Prospero (Pros) and Notch and NFkappaB. | The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NFκB feedback.
Kato K, Forero MG, Fenton JC, Hidalgo A., Free PMC Article | 02/25/2012 |
| propose that the Dorsal gradient supplies positional information throughout nuclear cycles 10-14 | Quantitative imaging of the Dorsal nuclear gradient reveals limitations to threshold-dependent patterning in Drosophila.
Liberman LM, Reeves GT, Stathopoulos A., Free PMC Article | 02/22/2010 |
| time-dependent properties of the Dl gradient are different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo | Dynamics of the Dorsal morphogen gradient.
Kanodia JS, Rikhy R, Kim Y, Lund VK, DeLotto R, Lippincott-Schwartz J, Shvartsman SY., Free PMC Article | 02/22/2010 |
| Dpp signals increase Cactus levels through Calpain A inhibition, thereby interfering with Dorsal activation | The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals.
Fontenele M, Carneiro K, Agrellos R, Oliveira D, Oliveira-Silva A, Vieira V, Negreiros E, Machado E, Araujo H. | 01/21/2010 |
| mutation analyses of genes known to act upstream of Dorsal revealed a requirement for the interleukin receptor-associated kinase family kinase Pelle for layer-specific targeting of photoreceptor axons | A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting.
Mindorff EN, O'Keefe DD, Labbé A, Yang JP, Ou Y, Yoshikawa S, van Meyel DJ., Free PMC Article | 01/21/2010 |
| Results support the view that methuselah expression is regulated by dorsal. | Transcriptional regulation of the methuselah gene by dorsal protein in Drosophila melanogaster.
Kim H, Kim J, Lee Y, Yang J, Han K. | 01/21/2010 |
| Two Xenopus Rel proteins can partially substitute for several, but not all, functions of the dl protein in Drosophila embryos. | Vertebrate Rel proteins exhibit Dorsal-like activities in early Drosophila embryogenesis.
Prothmann C, Armstrong NJ, Roth S, Rupp RA. | 01/21/2010 |
| The maternal Toll signaling pathway sets up a nuclear gradient of the transcription factor Dorsal in the early Drosophila embryo. | Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo.
Ganguly A, Jiang J, Ip YT. | 01/21/2010 |
| Cactus acts as an inhibitor of the Rel-transcription factors Dorsal and Dif. | The inhibitor kappaB-ortholog Cactus is necessary for normal neuromuscular function in Drosophila melanogaster.
Beramendi A, Peron S, Megighian A, Reggiani C, Cantera R. | 01/21/2010 |
| Dorsal and Cactus maybe necessary for normal function and maintenance of the neuromuscular system. These proteins can respond to synaptic activity. | Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila.
Bolatto C, Chifflet S, Megighian A, Cantera R. | 01/21/2010 |
| Dorsoventral patterning is not dependent upon Dorsal-mediated repression, reflecting the existence of redundant mechanisms to block Decapentaplegic signaling. | Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo.
Ratnaparkhi GS, Jia S, Courey AJ. | 01/21/2010 |
| The role of Pelle kinase and Twist in the Dorsal signaling pathway that specifies patterning thresholds of gene expression | Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset.
Stathopoulos A, Levine M. | 01/21/2010 |