| The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. | The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size.
Deng S, Silimon RL, Balakrishnan M, Bothe I, Juros D, Soffar DB, Baylies MK., Free PMC Article | 04/17/2021 |
| The Arp2/3 complex and the formin, Diaphanous, are both required to regulate the size of germline ring canals in the developing egg chamber. | The Arp2/3 complex and the formin, Diaphanous, are both required to regulate the size of germline ring canals in the developing egg chamber.
Thestrup J, Tipold M, Kindred A, Stark K, Curry T, Lewellyn L., Free PMC Article | 12/19/2020 |
| Using constitutively active Dia constructs, authors provide additional evidence that Dia functions upstream of SCAR activity to regulate actin dynamics at the fusion site and to localize the Abi-SCAR complex. | Diaphanous regulates SCAR complex localization during Drosophila myoblast fusion.
Deng S, Bothe I, Baylies M., Free PMC Article | 10/28/2017 |
| Dia plays two roles during invasive podosome formation at the fusion site: it dictates the level of linear F-actin polymerization, and it is required for appropriate branched actin polymerization via localization of SCAR and WASp. | The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation.
Deng S, Bothe I, Baylies MK., Free PMC Article | 05/14/2016 |
| Dia apical targeting also depends on binding to Rho1, which is critical for activation-induced conformational change, as well as physically anchoring Dia to the apical membrane | Apical targeting of the formin Diaphanous in Drosophila tubular epithelia.
Rousso T, Shewan AM, Mostov KE, Schejter ED, Shilo BZ., Free PMC Article | 07/25/2015 |
| Cdc42 and the formins diaphanous and DAAM play pivotal roles in heart lumen formation through the spatiotemporal regulation of the actomyosin network. | Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis.
Vogler G, Liu J, Iafe TW, Migh E, Mihály J, Bodmer R., Free PMC Article | 11/29/2014 |
| EnaEVH1 binds Dia directly and inhibits DiaFH1FH2-mediated nucleation in vitro | Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.
Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M., Free PMC Article | 04/26/2014 |
| The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. | The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
Yan S, Lv Z, Winterhoff M, Wenzl C, Zobel T, Faix J, Bogdan S, Grosshans J., Free PMC Article | 11/2/2013 |
| Drosophila and vertebrate APCs exhibit highly related activities and mechanisms and directly collaborate with formins such as diaphanous. | Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly.
Jaiswal R, Stepanik V, Rankova A, Molinar O, Goode BL, McCartney BM., Free PMC Article | 07/13/2013 |
| provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin | Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis.
Levayer R, Pelissier-Monier A, Lecuit T. | 07/16/2011 |
| Data show that flies expressing mutant diaphanous exhibit significantly reduced sound-evoked potentials (SEPs). | Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila.
Schoen CJ, Emery SB, Thorne MC, Ammana HR, Sliwerska E, Arnett J, Hortsch M, Hannan F, Burmeister M, Lesperance MM., Free PMC Article | 10/4/2010 |
| Dia and ena work together in a complex and nonadditive way, with the ratio between active Dia and Ena being one factor that modulates the balance between filopodia and lamellipodia. | Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia.
Homem CC, Peifer M., Free PMC Article | 03/15/2010 |
| APC2 and DIA function in a novel complex that affects actin directly, rather than through an effect on microtubules | A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila.
Webb RL, Zhou MN, McCartney BM., Free PMC Article | 01/21/2010 |
| Secretory vesicles are targeted to the apical membrane by MyoV-based transport, along polarized actin filaments nucleated by Dia. | Apical secretion in epithelial tubes of the Drosophila embryo is directed by the Formin-family protein Diaphanous.
Massarwa R, Schejter ED, Shilo BZ. | 01/21/2010 |
| DRhoGEF2 acts through Rho1 to regulate acto-myosin constriction but not Diaphanous-mediated F-actin nucleation during segmental groove morphogenesis. | DRhoGEF2 and diaphanous regulate contractile force during segmental groove morphogenesis in the Drosophila embryo.
Mulinari S, Barmchi MP, Häcker U., Free PMC Article | 01/21/2010 |
| A model is proposed in which Diaphanous links receptor tyrosine phosphatase signaling at the plasma membrane to growth-dependent modulation of the synaptic actin and microtubule cytoskeletons. | Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules.
Pawson C, Eaton BA, Davis GW., Free PMC Article | 01/21/2010 |
| role in regulating myosin levels and activity at adherens junctions during cell shape change, suggesting that Diaphanous helps coordinate adhesion and contractility of the underlying actomyosin ring | Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis.
Homem CC, Peifer M. | 01/21/2010 |
| RhoGEF2 and dia control position, shape and stability of the forming furrow canal by spatially restricted assembly of actin filaments required for the proper infolding of the plasma membrane | RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation.
Grosshans J, Wenzl C, Herz HM, Bartoszewski S, Schnorrer F, Vogt N, Schwarz H, Müller HA. | 01/21/2010 |