| Sequence reliance of the Drosophila context-dependent transcription factor CLAMP. | Sequence reliance of the Drosophila context-dependent transcription factor CLAMP.
Hodkinson LJ, Gross J, Schmidt CA, Diaz-Saldana PP, Aoki T, Rieder LE., | 08/1/2024 |
| Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila. | Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
Tikhonova E, Revel-Muroz A, Georgiev P, Maksimenko O., Free PMC Article | 03/14/2024 |
| Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites. | Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
Eggers N, Gkountromichos F, Krause S, Campos-Sparr A, Becker PB., Free PMC Article | 09/28/2023 |
| Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila. | Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
Tikhonova E, Mariasina S, Efimov S, Polshakov V, Maksimenko O, Georgiev P, Bonchuk A., Free PMC Article | 07/2/2022 |
| Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein. | Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein.
Tikhonova E, Mariasina S, Arkova O, Maksimenko O, Georgiev P, Bonchuk A., Free PMC Article | 04/23/2022 |
| CLAMP regulates zygotic genome activation in Drosophila embryos. | CLAMP regulates zygotic genome activation in Drosophila embryos.
Colonnetta MM, Abrahante JE, Schedl P, Gohl DM, Deshpande G., Free PMC Article | 03/26/2022 |
| The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome. | The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.
Jordan W 3rd, Larschan E., Free PMC Article | 01/22/2022 |
| CLAMP and Zelda function together to promote Drosophila zygotic genome activation. | CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
Duan J, Rieder L, Colonnetta MM, Huang A, Mckenney M, Watters S, Deshpande G, Jordan W, Fawzi N, Larschan E., Free PMC Article | 09/25/2021 |
| proper MSL2 positioning requires an interaction with either CLAMP or DNA to initiate dosage compensation in Drosophila males. | The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.
Tikhonova E, Fedotova A, Bonchuk A, Mogila V, Larschan EN, Georgiev P, Maksimenko O. | 07/4/2020 |
| hese are explained by physical interaction between MSL2 and CLAMP. In vivo, both factors cooperate to compete with nucleosome formation at HAS. The male-specific MSL2 thus synergises with a ubiquitous GA-repeat binding protein for refined X/autosome discrimination | Factor cooperation for chromosome discrimination in Drosophila.
Albig C, Tikhonova E, Krause S, Maksimenko O, Regnard C, Becker PB., Free PMC Article | 08/24/2019 |
| CLAMP regulates roX (RNA on the X) abundance in a sex-specific manner. | The essential Drosophila CLAMP protein differentially regulates non-coding roX RNAs in male and females.
Urban JA, Doherty CA, Jordan WT 3rd, Bliss JE, Feng J, Soruco MM, Rieder LE, Tsiarli MA, Larschan EN., Free PMC Article | 03/10/2018 |
| demonstrate that CLAMP associates with the transcriptional regulator complex Negative Elongation Factor (NELF) in both sexes and determine that CLAMP reduces NELF recruitment to several target genes | The Drosophila CLAMP protein associates with diverse proteins on chromatin.
Urban JA, Urban JM, Kuzu G, Larschan EN., Free PMC Article | 02/3/2018 |
| CLAMP increases chromatin accessibility, enhances histone gene transcription, and promotes histone locus body formation. | Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP.
Rieder LE, Koreski KP, Boltz KA, Kuzu G, Urban JA, Bowman SK, Zeidman A, Jordan WT 3rd, Tolstorukov MY, Marzluff WF, Duronio RJ, Larschan EN., Free PMC Article | 12/2/2017 |
| results support a model where synergy between a non-sex-specific transcription factor (CLAMP) and a sex-specific cofactor (MSL) creates a specialized chromatin domain on the male X-chromosome | Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein.
Urban J, Kuzu G, Bowman S, Scruggs B, Henriques T, Kingston R, Adelman K, Tolstorukov M, Larschan E., Free PMC Article | 11/25/2017 |
| analysis of how the CLAMP zinc finger protein links the dosage compensation complex to the X-chromosome | Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.
Kuzu G, Kaye EG, Chery J, Siggers T, Yang L, Dobson JR, Boor S, Bliss J, Liu W, Jogl G, Rohs R, Singh ND, Bulyk ML, Tolstorukov MY, Larschan E., Free PMC Article | 04/1/2017 |
| Understanding how the newly identified CLAMP protein is involved in X targeting in the fly could provide key insights into how the X chromosome is initially identified across species. | A new player in X identification: the CLAMP protein is a key factor in Drosophila dosage compensation.
Soruco MM, Larschan E., Free PMC Article | 08/1/2015 |