| IL2RB affects Th1/Th2 and Th17 responses of peripheral blood mononuclear cells from septic patients. | IL2RB affects Th1/Th2 and Th17 responses of peripheral blood mononuclear cells from septic patients.
Zhou J, Zhang Y, Zhuang Q. | 06/2/2023 |
| Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease. | Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease.
Liao Y, Ke B, Long X, Xu J, Wu Y., Free PMC Article | 08/13/2022 |
| Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms. | Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms.
Gao H, Wang L, Ren J, Liu Y, Liang S, Zhang B, Sun X. | 05/14/2022 |
| Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients. | Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients.
Gatselis NK, Lygoura V, Lyberopoulou A, Giannoulis G, Samakidou A, Vaiou A, Vatidis G, Antoniou K, Stefos A, Georgiadou S, Sagris D, Sveroni D, Stergioula D, Gabeta S, Ntaios G, Dalekos GN., Free PMC Article | 05/7/2022 |
| Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19. | Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19.
Luo K, Chen Y, Yang J, Tao Q, Luo M., Free PMC Article | 01/15/2022 |
| Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3. | Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3.
Zhao Y, Cai C, Samir J, Palgen JL, Keoshkerian E, Li H, Bull RA, Luciani F, An H, Lloyd AR. | 10/2/2021 |
| Impact of genetic variants in IL-2RA and IL-2RB on breast cancer risk in Chinese Han women. | Impact of genetic variants in IL-2RA and IL-2RB on breast cancer risk in Chinese Han women.
He L, Zhang W, Yang S, Meng W, Dou X, Liu J, Liu Y, Li H, Jin T. | 08/21/2021 |
| Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB. | Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB.
Lou W, Yan J, Wang W., Free PMC Article | 05/29/2021 |
| Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis. | Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis.
Schimmelpennink MC, Quanjel M, Vorselaars A, Wiertz I, Veltkamp M, Van Moorsel C, Grutters JC. | 03/20/2021 |
| In a Chinese Han population, we identified ADRB2 polymorphisms (rs1042711 and rs1560642) that were associated with increased risk of lung cancer, and polymorphisms in IL33 (rs7025417) and IL2RB (rs5756523 and rs2284033) that were associated with decreased disease risk. | Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population.
Mei L, Huang C, Wang A, Zhang X. | 04/25/2020 |
| three homozygous mutations in the IL2RB gene of eight individuals from four consanguineous families that cause disease by distinct mechanisms, are reported. | Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ., Free PMC Article | 04/18/2020 |
| the early-onset autoimmunity and immunodeficiency are linked to functional deficits arising from altered IL-2Rbeta expression and signaling in T and Natural killer cells. | A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY., Free PMC Article | 04/18/2020 |
| Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil. | Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil.
de Araújo Santos FJ, da Silva LS, Júnior JDES, Ramos de Mesquita TG, de Souza MLG, de Andrade Júnior MC, Talhari S, Ramasawmy R., Free PMC Article | 03/7/2020 |
| results showed that the IL2Rb polymorphisms were associated with lung cancer risk in the Chinese Han population | Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk.
Jia Z, Zhang Z, Yang Q, Deng C, Li D, Ren L. | 02/22/2020 |
| Here we have developed a novel CAR construct capable of inducing cytokine signaling after antigen stimulation. This new-generation CD19 CAR encodes a truncated cytoplasmic domain from the interleukin (IL)-2 receptor beta-chain (IL-2Rbeta) and a STAT3-binding tyrosine-X-X-glutamine (YXXQ) motif, together with the TCR signaling (CD3z) and co-stimulatory (CD28) domains (hereafter referred to as 28-DeltaIL2RB-z(YXXQ)). | A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.
Kagoya Y, Tanaka S, Guo T, Anczurowski M, Wang CH, Saso K, Butler MO, Minden MD, Hirano N., Free PMC Article | 05/11/2019 |
| This study shows that a PTPN2-rs7234029 polymorphism is associated with ocular Behcet's disease and is strongly influenced by gender. In addition, our results suggest that the genetic association with PTPN2 may involve the regulation of PTPN2 mRNA expression and cytokine secretion. | Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease.
Zhang Q, Li H, Hou S, Yu H, Su G, Deng B, Qi J, Zhou C, Kijlstra A, Yang P. | 04/6/2019 |
| Chimeric fusion protein of interleukin 2 (IL2) and its receptor interleukin 2 receptor, beta protein (IL2Rbeta) enhances antitumor activity of natural killer NK92 cells. | Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells.
Jounaidi Y, Cotten JF, Miller KW, Forman SA., Free PMC Article | 11/25/2017 |
| Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported. | Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.
Osinalde N, Sanchez-Quiles V, Akimov V, Aloria K, Arizmendi JM, Blagoev B, Kratchmarova I. | 10/21/2017 |
| Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis. | Prognostic value of the soluble interleukin-2 receptor level after patients with follicular lymphoma achieve a response to R-CHOP.
Umino K, Fujiwara SI, Ikeda T, Toda Y, Ito S, Mashima K, Minakata D, Nakano H, Yamasaki R, Kawasaki Y, Sugimoto M, Yamamoto C, Ashizawa M, Hatano K, Sato K, Oh I, Ohmine K, Muroi K, Kanda Y. | 10/14/2017 |
| Studies indicate many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes. | Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.
Lin M, Park S, Hayden A, Giustini D, Trinkaus M, Pudek M, Mattman A, Schneider M, Chen LYC. | 08/5/2017 |
| IL2RB thr-450 phosphorylation is a positive regulator for receptor-IL-2 complex stability and activation of signaling molecules. | Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
Ruiz-Medina BE, Ross JA, Kirken RA., Free PMC Article | 11/21/2015 |
| An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA positive Rheumatoid arthritis patients. | One year in review: the pathogenesis of rheumatoid arthritis.
Picerno V, Ferro F, Adinolfi A, Valentini E, Tani C, Alunno A. | 10/3/2015 |
| CD112 downregulation resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells. | Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells.
Grauwet K, Cantoni C, Parodi M, De Maria A, Devriendt B, Pende D, Moretta L, Vitale M, Favoreel HW., Free PMC Article | 04/18/2015 |
| IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis. | Abnormal expression pattern of the IL-2 receptor β-chain on CD4+ T cells in ANCA-associated vasculitis.
Wilde B, Hoerning A, Kribben A, Witzke O, Dolff S., Free PMC Article | 01/24/2015 |
| in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes. | Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts).
Ruyssen-Witrand A, Lukas C, Nigon D, Dawidowicz K, Morel J, Sibilia J, Jamard B, Cambon-Thomsen A, Cantagrel A, Dieudé P, Constantin A. | 10/25/2014 |