| Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling. | Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC., | 08/16/2024 |
| Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade. | Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade.
Chen S, Zhao T, Xie S, Wan X. | 03/14/2024 |
| The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease. | The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.
Li S, Lin L, Zhao J, Yang Z, Zhong Y, Huang L, Chen J, Zhang L, Ding Y, Xie T. | 11/3/2023 |
| IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma. | IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma.
Xu C, Gao M, Zhang J, Fu Y., Free PMC Article | 05/30/2023 |
| Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development. | Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development.
Laffey KG, Du J, Schrum AG, Ackerman SJ., Free PMC Article | 10/30/2021 |
| MiRNA-495-3p Attenuates TNF-alpha Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Targeting IL5RA. | MiRNA-495-3p Attenuates TNF-α Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Targeting IL5RA.
Lin X, Lin Q. | 07/17/2021 |
| Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy. | Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy.
Bakakos A, Rovina N, Bakakos P., Free PMC Article | 05/15/2021 |
| Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab. | Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab.
Landi C, Cameli P, Vantaggiato L, Bergantini L, d'Alessandro M, Perruzza M, Carleo A, Shaba E, Di Giuseppe F, Angelucci S, Bargagli E, Bini L. | 04/17/2021 |
| IL-5Ralpha marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. | IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM., Free PMC Article | 02/20/2021 |
| Expression of IL-5 receptor alpha by murine and human lung neutrophils. | Expression of IL-5 receptor alpha by murine and human lung neutrophils.
Gorski SA, Lawrence MG, Hinkelman A, Spano MM, Steinke JW, Borish L, Teague WG, Braciale TJ., Free PMC Article | 03/7/2020 |
| Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. | Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA.
van Rensburg IC, Wagman C, Stanley K, Beltran C, Ronacher K, Walzl G, Loxton AG., Free PMC Article | 02/24/2018 |
| Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review | Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs.
Varricchi G, Bagnasco D, Borriello F, Heffler E, Canonica GW., Free PMC Article | 12/17/2016 |
| This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. | IL5RA polymorphisms, smoking and eczema in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
Miyake Y, Tanaka K, Arakawa M. | 09/12/2015 |
| This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. | Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
Miyake Y, Tanaka K, Arakawa M. | 09/13/2014 |
| The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy. | Interaction of C1GALT1-IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese.
Wang W, Sun Y, Fu Y, Yu X, Li M. | 11/16/2013 |
| These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients. | A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease.
Losol P, Kim SH, Shin YS, Ye YM, Park HS., Free PMC Article | 10/26/2013 |
| The study reports the crystal structure of dimeric IL-5 in complex with the IL5RA extracellular domains. | Structural basis of interleukin-5 dimer recognition by its α receptor.
Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S., Free PMC Article | 09/15/2012 |
| REVIEW: Interleukin-5 and IL-5 receptor in health and disease | Interleukin-5 and IL-5 receptor in health and diseases.
Takatsu K., Free PMC Article | 05/5/2012 |
| we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. | Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Rα.
Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD. | 04/14/2012 |
| IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia | IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.
Wilson TM, Maric I, Shukla J, Brown M, Santos C, Simakova O, Khoury P, Fay MP, Kozhich A, Kolbeck R, Metcalfe DD, Klion AD., Free PMC Article | 12/17/2011 |
| Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function. | A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α.
Ishino T, Economou NJ, McFadden K, Zaks-Zilberman M, Jost M, Baxter S, Contarino MR, Harrington AE, Loll PJ, Pasut G, Lievens S, Tavernier J, Chaiken I. | 10/22/2011 |
| Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. | Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 diabetes--an 8-year prospective cohort analysis of 1327 Chinese patients.
Luk AO, Wang Y, Ma RC, Tam CH, Ng MC, Lam V, Yang X, Baum L, Tong PC, Chan JC, So WY. | 07/2/2011 |
| Increased serum level precedes the development of eczema in children | Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children.
Semic-Jusufagic A, Gevaert P, Bachert C, Murray C, Simpson A, Custovic A. | 05/21/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Syntenin forms complexes with multiple IL-5Ralpha chains | Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output.
Beekman JM, Verhagen LP, Geijsen N, Coffer PJ. | 01/21/2010 |