| A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled. | A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.
Humphries AC, Molina-Pelayo C, Sil P, Hazelett CC, Devenport D, Mlodzik M., Free PMC Article | 08/4/2023 |
| Report finds that Vang protein is required for the rotation of the DA1/VA1d dendritic pair. Vang functions in the olfactory receptor neurons (ORNs), suggesting a codependence of ORN axonal and projection neuron (PN) dendritic targeting. Loss of Vang suppressed the repulsion of the VA1d dendrites by Wnt5, indicating that Wnt5 signaling through Vang to direct the rotation of the DA1 and VA1d glomeruli. | Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe.
Hing H, Reger N, Snyder J, Fradkin LG., Free PMC Article | 08/1/2020 |
| The authors conclude that Casein Kinase Iepsilon phosphorylation acts as a switch, promoting Strabismus mobility and Dishevelled immobility, thus enhancing sorting of these proteins to opposite cell edges. | Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.
Strutt H, Gamage J, Strutt D., Free PMC Article | 02/29/2020 |
| Vang phosphorylation occurs on conserved N-terminal serine/threonine residues, is mediated by CK1epsilon/Dco, and is critical for polarized membrane localization of Vang and other PCP proteins. | Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila.
Kelly LK, Wu J, Yanfeng WA, Mlodzik M., Free PMC Article | 12/2/2017 |
| The transmembrane proteins Frizzled and Flamingo form a stoichiometric nucleus in the complex, while the relative levels of the other four core proteins can vary independently.we show that robust cell polarization is achieved over a range of complex stoichiometries but is dependent on maintaining appropriate levels of the components Frizzled and Strabismus. | Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry.
Strutt H, Gamage J, Strutt D., Free PMC Article | 11/25/2017 |
| Data indicate that Kermit interacts with Go and another PCP component Vang during planar cell polarity (PCP). | Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.
Lin C, Katanaev VL., Free PMC Article | 08/30/2014 |
| We propose that Stbm recruits farnesylated Pk into asymmetric complexes, but also promotes degradation of excess Pk that would otherwise perturb feedback amplification. | Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification.
Strutt H, Thomas-MacArthur V, Strutt D., Free PMC Article | 01/11/2014 |
| It physically interacts with and stabilizes Frizzled, and it mediates intercellular Frizzled-Van Gogh | The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization.
Chin ML, Mlodzik M., Free PMC Article | 12/14/2013 |
| We deduce that each cell has a mechanism to estimate and compare the numbers of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells. | Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
Struhl G, Casal J, Lawrence PA., Free PMC Article | 11/24/2012 |
| These data suggest that Nemo serves as a conserved molecular link between strabismus and prickle proteins and E-cadherin-beta-catenin complexes, promoting cell motility. | Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.
Mirkovic I, Gault WJ, Rahnama M, Jenny A, Gaengel K, Bessette D, Gottardi CJ, Verheyen EM, Mlodzik M., Free PMC Article | 06/25/2011 |
| results indicate that fate and direction of rotation can be genetically separated, and that there are stbm genes that act between R3/R4 fate specification and direction of ommatidial rotation | Screen for genetic modifiers of stbm reveals that photoreceptor fate and rotation can be genetically uncoupled in the Drosophila eye.
Wolff T, Guinto JB, Rawls AS., Free PMC Article | 05/3/2010 |
| Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment. | The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.
Courbard JR, Djiane A, Wu J, Mlodzik M., Free PMC Article | 01/21/2010 |
| Results indicate that both Van Gogh and Frizzled act as cues for downstream effectors orienting the planar polarity axis of dividing sensory organ precursor cells. | Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division.
Gomes JE, Corado M, Schweisguth F., Free PMC Article | 01/21/2010 |
| Data suggest that Vangogh/Stbm can act as a Frizzled (Fz) extracellular domain receptor, allowing cells to sense Fz activity/levels of their neighbors. | The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling.
Wu J, Mlodzik M., Free PMC Article | 01/21/2010 |
| role in development of cell boundaries for cell nuclei in Drosophila embryos in conjunction with Discs-Large protein | Discs-Large and Strabismus are functionally linked to plasma membrane formation.
Lee OK, Frese KK, James JS, Chadda D, Chen ZH, Javier RT, Cho KO., Free PMC Article | 01/21/2010 |
| Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. | Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.
Jenny A, Darken RS, Wilson PA, Mlodzik M., Free PMC Article | 01/21/2010 |
| the initial membrane association of Diego depends on Fz, and that Diego physically interacts with Strabismus and prickle through its Ankyrin repeats | Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.
Das G, Jenny A, Klein TJ, Eaton S, Mlodzik M. | 01/21/2010 |
| Stbm-dependent recruitment of Pins protein at the anterior cortex of the sense organ precursor cell is a novel read-out of planar cell polarity. | The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila.
Bellaïche Y, Beaudoin-Massiani O, Stuttem I, Schweisguth F. | 01/21/2010 |
| Data show that Strabismus becomes asymmetrically localised to the proximal edge of cells, then binds directly to Dishevelled and Prickle and is able to recruit them to membranes. | Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning.
Bastock R, Strutt H, Strutt D. | 01/21/2010 |
| Strabismus tissue polarity phenotype is enhanced by mutations in two other tissue polarity genes, flamingo and prickle. | Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye.
Rawls AS, Wolff T. | 01/21/2010 |
| Wnt signalling: a moving picture emerges from van gogh | Wnt signalling: a moving picture emerges from van gogh.
Heisenberg CP, Tada M. | 01/21/2010 |