| Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. | Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
Scholz N, Ehmann N, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T, Kittel RJ., Free PMC Article | 02/15/2020 |
| localization of BRP-an essential active zone scaffolding protein in Drosophila, depends on the precise balance of neuronal Par-1 kinase. | Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses.
Barber KR, Hruska M, Bush KM, Martinez JA, Fei H, Levitan IB, Dalva MB, Wairkar YP., Free PMC Article | 11/30/2019 |
| Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau | Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.
Barber KR, Tanquary J, Bush K, Shaw A, Woodson M, Sherman M, Wairkar YP., Free PMC Article | 05/27/2017 |
| The presynaptic protein Brp promotes evoked transmission and suppresses spontaneous release. | Evoked and spontaneous transmission favored by distinct sets of synapses.
Peled ES, Newman ZL, Isacoff EY., Free PMC Article | 04/9/2016 |
| The precise nanoscopic organization of Brp distinguishes different physiological active zones (AZs) and links functional diversification to a heretofore unrecognized neuronal gradient of the AZ cytomatrix ultrastructure. | Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states.
Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ., Free PMC Article | 03/12/2016 |
| CK2alpha is a novel regulator of the active zone protein, BRP, in Drosophila. | CK2α regulates the transcription of BRP in Drosophila.
Wairkar YP, Trivedi D, Natarajan R, Barnes K, Dolores L, Cho P. | 02/1/2014 |
| The macromolecular architecture created by the alternating pattern of the Bruchpilot isoforms determines the number of Ca(2+) channel-coupled SV release slots available per AZ and thereby sets the size of the RRP. | The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.
Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ., Free PMC Article | 11/23/2013 |
| This study found a circadian rhythm of BRP expression in the first optic neuropil (lamina) of the optic lobe and in the brain of D. melanogaster. In LD 12:12 the rhythm of BRP abundance is bimodal, displaying morning (ZT1) and evening (ZT13) peaks | Circadian expression of the presynaptic active zone protein Bruchpilot in the lamina of Drosophila melanogaster.
Górska-Andrzejak J, Makuch R, Stefan J, Görlich A, Semik D, Pyza E. | 05/25/2013 |
| Review describes how genetic elimination of Bruchpilot revealed that the protein is essential for T-bar formation, calcium channel clustering, and hence proper vesicle fusion and patterned synaptic plasticity. | The active zone T-bar--a plasticity module?
Wichmann C, Sigrist SJ. | 06/4/2011 |
| Bruchpilot, a ubiquitous presynaptic active zone protein, is required for anesthesia-resistant olfactory memory. | Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory.
Knapek S, Sigrist S, Tanimoto H., Free PMC Article | 05/14/2011 |
| Mutation of the Srpk79D gene causes conspicuous accumulations of BRP in larval and adult nerves. | Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila.
Nieratschker V, Schubert A, Jauch M, Bock N, Bucher D, Dippacher S, Krohne G, Asan E, Buchner S, Buchner E., Free PMC Article | 02/8/2010 |
| High resolution light microscopy, electron microscopy, and intravital imaging were used to analyze the function of BRP in active zone assembly. | Maturation of active zone assembly by Drosophila Bruchpilot.
Fouquet W, Owald D, Wichmann C, Mertel S, Depner H, Dyba M, Hallermann S, Kittel RJ, Eimer S, Sigrist SJ., Free PMC Article | 01/21/2010 |