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    Nlrp1a NLR family, pyrin domain containing 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360557, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease.

    Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease.
    Jia J, Liu H, Sun L, Xu Y, Zeng X.

    10/30/2024
    Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3beta Overactivation-Induced Hyperphosphorylated Tau in Rats.

    Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
    Liu X, Song W, Yu Y, Su J, Shi X, Yang X, Wang H, Liu P, Zou L.

    10/8/2022
    Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.

    Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
    Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J., Free PMC Article

    01/15/2022
    NLRP1 promoted myofibroblast differentiation and excessive ECM production in TGF-beta1-induced neonatal cardiac fibroblasts through directly targeting TGF-beta1/Smad signaling pathways.

    NLRP1 promotes TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts.
    Zong J, Zhang H, Li FF, Liang K, Liu JL, Xu LH, Qian WH.

    11/24/2018
    Inflammasome caspase-1 IL-1beta platform is involved in chronic constriction injury (CCI)-induced neuropathic pain and in lipoxin-induced analgesia.

    Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia.
    Li Q, Tian Y, Wang ZF, Liu SB, Mi WL, Ma HJ, Wu GC, Wang J, Yu J, Wang YQ.

    02/28/2015
    The NOD-like receptor NLRP1a/Caspase-1 pathway is the best candidate to mediate the parasite-induced cell death.

    A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.
    Cavailles P, Flori P, Papapietro O, Bisanz C, Lagrange D, Pilloux L, Massera C, Cristinelli S, Jublot D, Bastien O, Loeuillet C, Aldebert D, Touquet B, Fournié GJ, Cesbron-Delauw MF., Free PMC Article

    12/20/2014
    Hyperglycemia induces neuroinflammation through activation of NLRP1 inflammasome.

    Nod-like receptor protein 1 inflammasome mediates neuron injury under high glucose.
    Meng XF, Wang XL, Tian XJ, Yang ZH, Chu GP, Zhang J, Li M, Shi J, Zhang C.

    11/22/2014
    Our findings reveal Toxoplasma as a novel activator of the NLRP1 inflammasome in rat macrophages.

    Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.
    Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M., Free PMC Article

    11/8/2014
    Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1beta production in acute glaucoma.

    Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.
    Chi W, Li F, Chen H, Wang Y, Zhu Y, Yang X, Zhu J, Wu F, Ouyang H, Ge J, Weinreb RN, Zhang K, Zhuo Y., Free PMC Article

    11/8/2014
    Age-related cognitive decline may involve a heightened inflammatory response associated with activation of the NLRP1 inflammasome in the hippocampus.

    Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.
    Mawhinney LJ, de Rivero Vaccari JP, Dale GA, Keane RW, Bramlett HM., Free PMC Article

    08/25/2012
    Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.

    Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.
    Levinsohn JL, Newman ZL, Hellmich KA, Fattah R, Getz MA, Liu S, Sastalla I, Leppla SH, Moayeri M., Free PMC Article

    07/14/2012
    toxin-mediated lethality in rats as well as macrophage sensitivity in anthrax animal model are controlled by a single locus on chromosome 10 that is likely to be the inflammasome NLR sensor, Nlrp1

    Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.
    Newman ZL, Printz MP, Liu S, Crown D, Breen L, Miller-Randolph S, Flodman P, Leppla SH, Moayeri M., Free PMC Article

    08/30/2010
    These data suggest that NALP1 and NALP5 may regulate caspase activation and apoptosis in injured neurons.

    Induced expression of death domain genes NALP1 and NALP5 following neuronal injury.
    Frederick Lo C, Ning X, Gonzales C, Ozenberger BA.

    01/21/2010
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