| The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. | The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.
Zhao S, Hu Y, Yang B, Zhang L, Xu M, Jiang K, Liu Z, Wu M, Huang Y, Li P, Liang SJ, Sun X, Hide G, Lun ZR, Wu Z, Shen J., Free PMC Article | 02/8/2024 |
| MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension. | MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension.
Lu Y, Li D, Shan L. | 11/30/2023 |
| miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells. | miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells.
Li Y, Long Y, Zhi X, Hao H, Wang X, Liu H, Wang L., Free PMC Article | 05/8/2023 |
| Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling. | Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling.
Samanta J, Mondal A, Das S, Chakraborty S, Sengupta A. | 03/26/2022 |
| MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3. | MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.
Zhao M, Wang W, Lu Y, Wang N, Kong D, Shan L., Free PMC Article | 05/8/2021 |
| We demonstrate that TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management. | Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.
Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Farès N., Free PMC Article | 07/4/2020 |
| AKAP79/150 LZ motif functions to recruit NFAT to the L-type calcium channels signaling complex to promote its activation by AKAP-anchored calcineurin. | AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca(2+) channels.
Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML., Free PMC Article | 01/11/2020 |
| the activation of TRPV3 aggravated pathological cardiac hypertrophy through calcineurin/NFATc3 signalling pathway and correlated with the protein expression levels of calcineurin, phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a potential therapeutic target for cardiac hypertrophy. | Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.
Zhang Q, Qi H, Cao Y, Shi P, Song C, Ba L, Chen Y, Gao J, Li S, Li B, Sun H., Free PMC Article | 11/2/2019 |
| This study is the first time that radiation-induced activation of NFAT3/c4 has been recorded. | NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury.
Xu M, Fan Q, Zhang J, Chen Y, Xu R, Chen L, Zhao P, Tian Y., Free PMC Article | 07/28/2018 |
| releases of Ca(2+) from the endoplasmic reticulum (ER), and consequently drives STIM1 aggregation and an inhibitory interaction with LTCCs that increases spine ER content but decreases NFATc3 nuclear translocation. | STIM1 Ca(2+) Sensor Control of L-type Ca(2+)-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling.
Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA., Free PMC Article | 05/6/2017 |
| Thus, all these results indicate that 15-HETE-mediated PASMCs anti-apoptosis in hypoxic PH via the Ca(2+)-NFATc3 pathway. | NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia.
Ran Y, Wu H, Wei L, Yu X, Chen J, Li S, Zhang L, Lou J, Zhu D. | 04/4/2015 |
| NGF facilitates depolarization-induced NFAT activation by stimulating PI3K/Akt signaling, inactivating GSK3beta, and thereby slowing NFATc3 export from the nucleus | Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway.
Kim MS, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM., Free PMC Article | 01/24/2015 |
| After TBI insult, in the hippocampus ipsilateral to the injury, NFATc3 expression levels were decreased both in the cytoplasmic and nuclear fractions. | Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus.
Yan HQ, Shin SS, Ma X, Li Y, Dixon CE., Free PMC Article | 09/27/2014 |
| COX-2 and NFATc3 signaling are involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes. | COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3.
Li H, Gao S, Ye J, Feng X, Cai Y, Liu Z, Lu J, Li Q, Huang X, Chen S, Liu P. | 08/23/2014 |
| Associated with calcineurin-dependent nuclear translocation of the NFATc3 isoform. | Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation.
Zhao L, Sullivan MN, Chase M, Gonzales AL, Earley S., Free PMC Article | 08/16/2014 |
| Silencing of stromal interaction molecule (STIM)1 inhibits nuclear translocation of nuclear factor of activated T cells (NFATc)3 in hypoxic pulmonary artery smooth muscle cells. | Silencing of STIM1 attenuates hypoxia-induced PASMCs proliferation via inhibition of the SOC/Ca2+/NFAT pathway.
Hou X, Chen J, Luo Y, Liu F, Xu G, Gao Y., Free PMC Article | 12/21/2013 |
| IGF-1 regulates myostatin transcription through the activation of the NFATc3 transcription factor in an IP3 /calcium-dependent manner. This study demonstrates a role of calcium-dependent signaling pathways in the mRNA expression of myostatin. | IGF-1 induces IP3 -dependent calcium signal involved in the regulation of myostatin gene expression mediated by NFAT during myoblast differentiation.
Valdés JA, Flores S, Fuentes EN, Osorio-Fuentealba C, Jaimovich E, Molina A. | 11/16/2013 |
| Data indicate that NFATc3 undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol. | Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.
Ulrich JD, Kim MS, Houlihan PR, Shutov LP, Mohapatra DP, Strack S, Usachev YM., Free PMC Article | 01/26/2013 |
| Hypertrophy-dependent CryAB gene expression can be attributed to a functional linkage between the Jak/STAT and calcineurin/NFAT signalling pathways. | Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.
Manukyan I, Galatioto J, Mascareno E, Bhaduri S, Siddiqui MA., Free PMC Article | 11/27/2010 |
| NFATc3 can promote myocardin expression, whereas miR-9 is able to suppress myocardin expression, thereby regulating cardiac hypertrophy. | miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy.
Wang K, Long B, Zhou J, Li PF., Free PMC Article | 05/10/2010 |
| NFAT-3 has a role as a direct transcriptional repressor of GAP-43 expression | NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation.
Nguyen T, Lindner R, Tedeschi A, Forsberg K, Green A, Wuttke A, Gaub P, Di Giovanni S., Free PMC Article | 01/21/2010 |
| miR-23a is a pro-hypertrophic miRNA, and its expression is regulated by the transcription factor, nuclear factor of activated T cells (NFATc3). | miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy.
Lin Z, Murtaza I, Wang K, Jiao J, Gao J, Li PF., Free PMC Article | 01/21/2010 |
| These findings further provide a link between the lipopolysaccharide-induced inflammatory response and the calcineurin/NFAT-3 signaling pathway that mediates the development of cardiac hypertrophy. | Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells.
Liu CJ, Cheng YC, Lee KW, Hsu HH, Chu CH, Tsai FJ, Tsai CH, Chu CY, Liu JY, Kuo WW, Huang CY. | 01/21/2010 |
| NFATc3 expression in pericytes from parenchymal microvessels and in astrocytes from native tissue | Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels.
Filosa JA, Nelson MT, Gonzalez Bosc LV. | 01/21/2010 |
| NFATc3 controls the excitability of arterial smooth muscle by regulating Kv2.1 expression | NFATc3 regulates Kv2.1 expression in arterial smooth muscle.
Amberg GC, Rossow CF, Navedo MF, Santana LF. | 01/21/2010 |