| C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms. | C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Okada A, Shimizu K, Kawashima A, Kayahara T, Itani M, Kurita H, Miyamoto S, Kataoka H, Aoki T., Free PMC Article | 02/14/2024 |
| Immunopathology of terminal complement activation and complement C5 blockade creating a pro-survival and organ-protective phenotype in trauma. | Immunopathology of terminal complement activation and complement C5 blockade creating a pro-survival and organ-protective phenotype in trauma.
Yang Z, Nunn MA, Le TD, Simovic MO, Edsall PR, Liu B, Barr JL, Lund BJ, Hill-Pryor CD, Pusateri AE, Cancio LC, Li Y., Free PMC Article | 01/21/2023 |
| Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-kappabeta and ASK1 Pathways. | Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways.
Vinay P, Karen C, Balamurugan K, Rajan KE. | 08/28/2021 |
| Evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of diabetic kidney disease (DKD) by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD. | Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
Tan SM, Ziemann M, Thallas-Bonke V, Snelson M, Kumar V, Laskowski A, Nguyen TV, Huynh K, Clarke MV, Libianto R, Baker ST, Skene A, Power DA, MacIsaac RJ, Henstridge DC, Wetsel RA, El-Osta A, Meikle PJ, Wilson SG, Forbes JM, Cooper ME, Ekinci EI, Woodruff TM, Coughlan MT. | 07/11/2020 |
| IL-1beta can increase C5a expression in RSC-364 cells, and C5a exerts a proinflammatory effect in RSC-364 cells. | Inhibition of C5a prevents IL-1β-induced alternations in rat synoviocytes in vitro.
Lu W, Wang L, Yao J, Wang W, Chen Y. | 03/9/2019 |
| The expression of C5a was increased in synoviocytes and joint cartilage in the IM model. Proinflammatory cytokines, including TNFalpha and IL1beta were released in the activated synoviocytes via the induction of C5a, suggesting that C5a serves an important role in joint inflammatory processes. | C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization.
Lu W, Wang L, Yao J, Wo C, Chen Y., Free PMC Article | 10/20/2018 |
| n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent. | Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI).
Kalbitz M, Karbach M, Braumueller S, Kellermann P, Gebhard F, Huber-Lang M, Perl M., Free PMC Article | 07/22/2017 |
| Data indicate that absence of complement C3, complement C5 and Fc receptor subunit gamma (FcRgamma) does not impact autoantibody production in K/BxN mice. | Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade.
Auger JL, Haasken S, Binstadt BA., Free PMC Article | 05/16/2015 |
| Th data of this study suggested a role for the Complement C5 in malaria-induced seizures and that inhibition of the terminal complement pathway may reduce seizures and seizure-related neurocognitive deficits. | Complement C5-deficient mice are protected from seizures in experimental cerebral malaria.
Buckingham SC, Ramos TN, Barnum SR., Free PMC Article | 03/7/2015 |
| data indicate that the mechanism of IL-6 and TGF-beta1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPbeta acetylation | Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation.
Zhang J, Li Y, Shan K, Wang L, Qiu W, Lu Y, Zhao D, Zhu G, He F, Wang Y. | 05/3/2014 |
| Early immune-inflammatory response to blast injury involves complement and TNFalpha, which correlates with hippocampus and cerebral cortex damage. | Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor α (TNFα) release in a rat brain.
Dalle Lucca JJ, Chavko M, Dubick MA, Adeeb S, Falabella MJ, Slack JL, McCarron R, Li Y. | 03/30/2013 |
| The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury. | Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
Ren G, Huynh C, Bijian K, Cybulsky AV. | 12/8/2011 |
| Neutralization of C5a greatly ameliorates pathophysiological changes associated with septic encephalopathy. | Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis.
Flierl MA, Stahel PF, Rittirsch D, Huber-Lang M, Niederbichler AD, Hoesel LM, Touban BM, Morgan SJ, Smith WR, Ward PA, Ipaktchi K., Free PMC Article | 03/8/2010 |
| C3a and C5a mediate distinct effects on blood pressure and circulating polymorphonuclear leukocytes in the rat. | Complement factors C3a and C5a have distinct hemodynamic effects in the rat.
Proctor LM, Moore TA, Monk PN, Sanderson SD, Taylor SM, Woodruff TM. | 01/21/2010 |
| anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis | The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis.
Flierl MA, Rittirsch D, Chen AJ, Nadeau BA, Day DE, Sarma JV, Huber-Lang MS, Ward PA., Free PMC Article | 01/21/2010 |
| C5a is an important inflammatory hypernociceptive mediator, acting by a mechanism independent of hypernociceptive cytokine release, but dependent on the presence of neutrophils | Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain.
Ting E, Guerrero AT, Cunha TM, Verri WA Jr, Taylor SM, Woodruff TM, Cunha FQ, Ferreira SH., Free PMC Article | 01/21/2010 |
| blunt chest trauma leads to systemic activation of complement and robust C5a generation, which causes perturbations in defensive functions of neutrophils | The role of C5a in the innate immune response after experimental blunt chest trauma.
Flierl MA, Perl M, Rittirsch D, Bartl C, Schreiber H, Fleig V, Schlaf G, Liener U, Brueckner UB, Gebhard F, Huber-Lang MS. | 01/21/2010 |
| Our findings demonstrate that C5a may have a role in the activation of the HPA axis in response to systemic LPS. | Systemic blockade of complement C5a receptors reduces lipopolysacharride-induced responses in the paraventricular nucleus and the central amygdala.
Crane JW, Buller KM. | 01/21/2010 |
| The molecular basis has been defined for C5a-induced loss of the respiratory burst in neutrophils during experimental sepsis induced by cecal ligation-puncture. | Complement-induced impairment of innate immunity during sepsis.
Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Curnutte JT, Erickson R, Ward PA. | 01/21/2010 |
| antibody-blockade of C5a in rats significantly reduced serum levels of IL-6 during sepsis | Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis.
Riedemann NC, Guo RF, Hollmann TJ, Gao H, Neff TA, Reuben JS, Speyer CL, Sarma JV, Wetsel RA, Zetoune FS, Ward PA. | 01/21/2010 |
| results indicate a pivotal role for C5a in inducing local and remote organ injury and suggest a possible new drug therapeutic category for preventing anticipated tissue injury associated with ischemia-reperfusion | Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats.
Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM. | 01/21/2010 |
| Mechanical properties of rat bone marrow and circulating neutrophils and their responses to inflammatory mediator C5. | Mechanical properties of rat bone marrow and circulating neutrophils and their responses to inflammatory mediators.
Saito H, Lai J, Rogers R, Doerschuk CM. | 01/21/2010 |
| complement 5 may mediate tissue damage during GI/R by increasing intestinal iNOS and decreasing the activity and protein levels of Cu/Zn SOD and Mn SOD, respectively. | Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression.
Montalto MC, Hart ML, Jordan JE, Wada K, Stahl GL. | 01/21/2010 |
| C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury | Role of complement component C5 in cerebral ischemia/reperfusion injury.
Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y. | 01/21/2010 |
| C5L2 is a highly regulated scavenger receptor for C5a and C5a-des-Arg(74) | Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.
Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk PN, Klos A. | 01/21/2010 |