| Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila. | Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila.
Flores-Flores M, Muñoz-Nava LM, Rodríguez-Muñoz R, Zartman J, Nahmad M., Free PMC Article | 05/22/2023 |
| A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species. | A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.
Farfán-Pira KJ, Martínez-Cuevas TI, Evans TA, Nahmad M., Free PMC Article | 05/22/2023 |
| Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc. | Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc.
Fan WM, Luo D, Zhang JZ, Wang D, Shen J. | 02/2/2021 |
| Study shows that Polycomb Response Elements (PREs) near the wing selector gene vestigial have distinctive roles at their endogenous locus, even though both PREs are repressors in transgenes. First, a PRE near the promoter is required for vestigial activation and not for repression. Second, only the distal PRE contributes to H3K27me3, but even removal of both PREs does not eliminate H3K27me3 across the vestigial domain. | Separate Polycomb Response Elements control chromatin state and activation of the vestigial gene.
Ahmad K, Spens AE., Free PMC Article | 01/11/2020 |
| Vestigial protein phosphorylation of serine 215 occurs in the nucleus and requires the presence of Scalloped. | The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
Pimmett VL, Deng H, Haskins JA, Mercier RJ, LaPointe P, Simmonds AJ. | 09/16/2017 |
| here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout beta-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts. | Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors.
Vishal K, Brooks DS, Bawa S, Gameros S, Stetsiv M, Geisbrecht ER., Free PMC Article | 07/15/2017 |
| High hydrostatic pressure-induced wing mutagenesis in Drosophila melanogaster resulted in 285 differentially expressed genes and two point mutations in the vestigial gene. | Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster.
Wang H, Wang K, Xiao G, Ma J, Wang B, Shen S, Fu X, Zou G, Zou B., Free PMC Article | 08/13/2016 |
| Data show that genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity, and the acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial. | Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
Carrasco-Rando M, Tutor AS, Prieto-Sánchez S, González-Pérez E, Barrios N, Letizia A, Martín P, Campuzano S, Ruiz-Gómez M., Free PMC Article | 12/31/2011 |
| Studies indicate that negative regulation of the Vestigial gradient by Wingless signaling makes vestigial expression precise and robust. | Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control.
Zhu H. | 03/5/2011 |
| Vg is a key factor to induce specific changes in ventral longitudinal muscles 1-4 identity and is required for these cells to be competent to form stable intermuscular attachments with each other. | Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos.
Deng H, Bell JB, Simmonds AJ., Free PMC Article | 01/22/2011 |
| Data show that vestigial is controlled by the Notch anti-myogenic signaling pathway in myoblasts and is regulated by a novel 822 bp enhancer during indirect flight muscle differentiation. | Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene.
Bernard F, Kasherov P, Grenetier S, Dutriaux A, Zider A, Silber J, Lalouette A. | 01/21/2010 |
| Data show that both Vestigial and Scalloped are required for muscle differentiation, as loss of either leads to a loss of a subset of either cardiac or somatic muscle cells in developing embryos, and also that Sd, Vg, and Dmef2 can interact directly. | Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster.
Deng H, Hughes SC, Bell JB, Simmonds AJ., Free PMC Article | 01/21/2010 |
| vg-dependent, vg-inducing signal feeds forward from one cell to the next to entrain surrounding cells to join the growing wing primordium in response to Wg. | Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation.
Zecca M, Struhl G. | 01/21/2010 |
| Control of Drosophila wing growth by the vestigial quadrant enhancer. | Control of Drosophila wing growth by the vestigial quadrant enhancer.
Zecca M, Struhl G. | 01/21/2010 |
| We show that the ectopic expression of vestigial only induces ectopic outgrowths with wing cuticular differentiation and wing blade gene expression patterns in specific developmental and genetic contexts. | Genetic requirements of vestigial in the regulation of Drosophila wing development.
Baena-López LA, García-Bellido A. | 01/21/2010 |
| the Vestigial/Scalloped transcription complex has a role during wing development in Drosophila melanogaster | Further developmental roles of the Vestigial/Scalloped transcription complex during wing development in Drosophila melanogaster.
Srivastava A, Bell JB. | 01/21/2010 |
| a critical player for both cell proliferation and cell survival in the presumptive wing margin area | The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc.
Delanoue R, Legent K, Godefroy N, Flagiello D, Dutriaux A, Vaudin P, Becker JL, Silber J. | 01/21/2010 |
| vestigial function in the differentiating dorsal longitudinal muscles is achieved through the inhibition of the Notch pathway | Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster.
Bernard F, Dutriaux A, Silber J, Lalouette A. | 01/21/2010 |
| vg appears to be a key regulatory gene of IFM development | Control of apterous by vestigial drives indirect flight muscle development in Drosophila.
Bernard F, Lalouette A, Gullaud M, Jeantet AY, Cossard R, Zider A, Ferveur JF, Silber J. | 01/21/2010 |
| Differences in vestigial expression between neighboring cells of the wing blade autonomously and nonautonomously affect cell proliferation along the proximo-distal axis. | Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster.
Baena-Lopez LA, García-Bellido A., Free PMC Article | 01/21/2010 |
| Expression of the VGDeltaACT construct in the wing alters the cellular localization of VG and produces a mutant phenotype, indicating that the construct is able to antagonize the normal function of the SD/VG complex. | Antagonizing scalloped with a novel vestigial construct reveals an important role for scalloped in Drosophila melanogaster leg, eye and optic lobe development.
Garg A, Srivastava A, Davis MM, O'Keefe SL, Chow L, Bell JB., Free PMC Article | 01/21/2010 |
| Data show that normal cell proliferation is necessary for apterous expression at the level of the dorso-ventral boundary, which is mediated by vestigial, interacting in a dose-dependent way with apterous. | Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc.
Delanoue R, Zider A, Cossard R, Dutriaux A, Silber J. | 01/21/2010 |
| A negative association between the vg expressiveness and the degree of chromosome polyteny was revealed and proved to be stronger in females than in males. | [The effect of the genotype on the expressiveness of the vestigial trait and polyteny of chromosomes in Drosophila melanogaster Meig].
Kirpichenko TV, Strashniuk VIu, Vorob'eva LI, Shakhbazov VG. | 01/21/2010 |
| Sumoylation by SUMO stimulates Vg function during wing morphogenesis. | SUMO enhances vestigial function during wing morphogenesis.
Takanaka Y, Courey AJ. | 01/21/2010 |
| Data show that Wingless (Wg) and Vestigial (Vg) are differentially regulated in wing and haltere discs. | Regulation of Wingless and Vestigial expression in wing and haltere discs of Drosophila.
Prasad M, Bajpai R, Shashidhara LS. | 01/21/2010 |