| Toll-like receptor 3 neuroimmune signaling and behavior change: A strain comparison between Lewis and Wistar rats. | Toll-like receptor 3 neuroimmune signaling and behavior change: A strain comparison between Lewis and Wistar rats.
Giffin KA, Lovelock DF, Besheer J., Free PMC Article | 12/10/2022 |
| TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner. | TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner.
Schilling S, Chausse B, Dikmen HO, Almouhanna F, Hollnagel JO, Lewen A, Kann O. | 08/14/2021 |
| Data support a role for FAAH, but not MAGL, substrates in the modulation of TLR3-induced neuroinflammatory responses, effects independent of sex. | FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.
Flannery LE, Henry RJ, Kerr DM, Finn DP, Roche M. | 11/30/2019 |
| Sevoflurane intervention can activate TLR3 and TLR9 signaling pathway, upregulate TLR3 expression and downstream TRIF expression, decrease TLR9 expression, and downregulate downstream NF-kappaB expression in CPB rat models, thereby mitigating brain injury induced by inflammatory response during CPB. | Effects of TLR3 and TLR9 Signaling Pathway on Brain Protection in Rats Undergoing Sevoflurane Pretreatment during Cardiopulmonary Bypass.
Nan Z, Jin Z, Huijuan C, Tiezheng Z, Keyan C., Free PMC Article | 08/18/2018 |
| Spinal nerve ligation induces the expression of TLR3 in dorsal root ganglion cells. | Upregulated TLR3 Promotes Neuropathic Pain by Regulating Autophagy in Rat With L5 Spinal Nerve Ligation Model.
Chen W, Lu Z. | 03/11/2017 |
| role of TLR3/BAFF axis in IgA class-switch recombination of IgA nephropathy | Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis.
He L, Peng X, Wang J, Tang C, Zhou X, Liu H, Liu F, Sun L, Peng Y. | 08/13/2016 |
| SA00025 displayed anti-inflammatory activity in the 6-OHDA lesion model primed with the TLR3 dsRNA inflammatory stimulant (poly(I:C)) | A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O., Free PMC Article | 02/20/2016 |
| TLR3 expression was enhanced in the basilar arteries and hippocampus when the rats suffered from subarachnoid hemorrhage | [Enhanced expression of Toll-like receptor 3 in the basilar arteries and hippocampus of subarachnoid hemorrhage rats].
Xing W, Tan G, He C. | 11/14/2015 |
| MiR-26a negatively regulates TLR3 signaling via targeting of TLR3 itself in rat macrophages, and this finding provides a novel insight into abnormal TLR3 overexpression during experimental arthritis. | MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats.
Jiang C, Zhu W, Xu J, Wang B, Hou W, Zhang R, Zhong N, Ning Q, Han Y, Yu H, Sun J, Meng L, Lu S., Free PMC Article | 09/26/2015 |
| IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state | Brain interleukin-1β and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats.
Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, Watanabe Y, Kataoka Y., Free PMC Article | 05/30/2015 |
| TNF-alpha derived from pristane primed T cells induced TLR3 expression of fibroblast-like synoviocytes through activating p38 MAPK and NF-kappaB pathways. | Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-α initiated p38 MAPK and NF-κB pathways.
Zhu W, Jiang C, Xu J, Geng M, Wu X, Sun J, Ma J, Holmdahl R, Meng L, Lu S. | 05/2/2015 |
| This study showed that TLR-3 is expressed in the immature brain and mediates preconditioning against ischemic injury. | TLR-3 receptor activation protects the very immature brain from ischemic injury.
Shi H, Gabarin N, Hickey E, Askalan R., Free PMC Article | 02/28/2015 |
| Ischemic preconditioning-induced ischemic tolerance is mediated by astrocytic TLR3 signaling. | Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in rodents.
Pan LN, Zhu W, Li Y, Xu XL, Guo LJ, Lu Q, Wang J., Free PMC Article | 01/31/2015 |
| TLR3 is expressed by quiescent hepatic stellate cells (HSC) where it functions to induce transcription and secretion of functional interferons as well as a number of other cytokines and chemokines. | Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA., Free PMC Article | 09/13/2014 |
| aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes. | Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF. | 08/23/2014 |
| Poly(I:C) downregulated TLR4 signaling via TLR3. | Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3.
Wang PF, Fang H, Chen J, Lin S, Liu Y, Xiong XY, Wang YC, Xiong RP, Lv FL, Wang J, Yang QW., Free PMC Article | 06/28/2014 |
| Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. | Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation.
Khalil OS, Forrest CM, Pisar M, Smith RA, Darlington LG, Stone TW. | 04/19/2014 |
| The TLR3/IFR3-IFN-beta signaling pathway may contribute to the reduced inflammatory response after stroke. Chloroquine warrants further investigation as a therapeutic agent for the treatment of stroke. | Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke.
Cui G, Ye X, Zuo T, Zhao H, Zhao Q, Chen W, Hua F. | 02/8/2014 |
| Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis. | Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring.
Forrest CM, Khalil OS, Pisar M, Smith RA, Darlington LG, Stone TW., Free PMC Article | 06/22/2013 |
| Toll-like receptor 3 plays a key role in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in rat hypoxia. | A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model.
Biswas I, Garg I, Singh B, Khan GA. | 12/22/2012 |
| we conclude that overexpression of splenic TLR3 is strongly associated with arthritis in rats | Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats.
Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, Lu S. | 10/27/2012 |
| TLR3 in the synovium of pristane induced arthritis rats was overexpressed, and activation of the TLR3 signaling pathway could aggravate this arthritis. | Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts.
Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S., Free PMC Article | 03/17/2012 |
| The TLR3 signal pathway may play an important role in early stage of respiratory syncytial virus nephropathy. | [Activation of TLR3 pathway in the pathogenesis of nephrotic syndrome induced by respiratory syncytial virus in rat model].
Wu J, Wang Z, Guo YN, Dong LQ. | 10/1/2011 |
| TLR3 in mediastinal lymph node and TLR7 in spleen both systemically modulate disease development in antigen induced pulmonary inflammation rats via altering serum IgE concentration relevant to Th2 responses. | TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs.
Meng L, He X, Zhu W, Yang X, Jiang C, Sun Q, M B, Zhang S, Xue Q, Xie X, Lu S., Free PMC Article | 09/3/2011 |
| Cellular RNA released from necrotic cells can act as an endogenous TLR3 ligand to induce clusterin expression in vitro in vascular smooth muscle cells and in vivo. | Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.
Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C. | 01/29/2011 |