| Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma. | Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma.
Chong PSY, Chooi JY, Lim SLJ, Chung TH, Brunmeir R, Leow ACY, Toh SHM, Balan K, Azaman MIB, Wu Z, Subramaniam N, Vardy LA, Chng WJ., Free PMC Article | 07/8/2024 |
| MiR-335-3p inhibits cell proliferation and induces cell cycle arrest and apoptosis in acute myeloid leukemia by targeting EIF3E. | MiR-335-3p inhibits cell proliferation and induces cell cycle arrest and apoptosis in acute myeloid leukemia by targeting EIF3E.
Zhang L, Wang X, Wu J, Xiao R, Liu J. | 01/15/2022 |
| eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health. | eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health.
Lin Y, Li F, Huang L, Polte C, Duan H, Fang J, Sun L, Xing X, Tian G, Cheng Y, Ignatova Z, Yang X, Wolf DA. | 09/26/2020 |
| An EIF3E-RSPO2 fusion was detected in three colorectal serrated polyps | EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma.
Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S. | 01/25/2020 |
| Data suggest that decreased eukaryotic translation initiation factor 3 subunit e expression may pave way for epithelial-mesenchymal transition in the development of adenomyosis through activating the TGF-beta1 signaling pathway. | The Possible Role of Eukaryotic Translation Initiation Factor 3 Subunit e (eIF3e) in the Epithelial-Mesenchymal Transition in Adenomyosis.
Cai X, Shen M, Liu X, Nie J. | 04/20/2019 |
| These data suggest that eIF3e downregulation may be involved in epithelial-mesenchymal transition in endometriosis, possibly through preferential translation of Snail. | Reduced Expression of Eukaryotic Translation Initiation Factor 3 Subunit e and Its Possible Involvement in the Epithelial-Mesenchymal Transition in Endometriosis.
Cai X, Shen M, Liu X, Guo SW. | 07/28/2018 |
| A transcript-specific eIF3 complex mediates global translational control of energy metabolism. | A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
Shah M, Su D, Scheliga JS, Pluskal T, Boronat S, Motamedchaboki K, Campos AR, Qi F, Hidalgo E, Yanagida M, Wolf DA., Free PMC Article | 11/18/2017 |
| INT6 protects against breast cancer by showing how it functions in DSB repair, with potential clinical implications for cancer therapy. | INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.
Morris C, Tomimatsu N, Burma S, Jalinot P., Free PMC Article | 08/12/2017 |
| eIF3e is an angiogenesis suppressor. Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity. | Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2α activity.
Hashimoto T, Chen L, Kimura H, Endler A, Koyama H, Miyata T, Shibasaki F, Watanabe T. | 05/27/2017 |
| High eIF3e expression may contribute to tumor progression and predict poor prognosis in colon cancer. | Overexpression of eIF3e is correlated with colon tumor development and poor prognosis.
Li Z, Lin S, Jiang T, Wang J, Lu H, Tang H, Teng M, Fan J., Free PMC Article | 07/25/2015 |
| Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells. | Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.
Sesen J, Cammas A, Scotland SJ, Elefterion B, Lemarié A, Millevoi S, Mathew LK, Seva C, Toulas C, Moyal EC, Skuli N., Free PMC Article | 12/20/2014 |
| 40S ribosome loading imparts a phosphorylation mark on the cap-binding eIF4F complex that regulates selective mRNA translation and is synchronized by a specific eIF3 subunit | Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.
Walsh D, Mohr I., Free PMC Article | 05/31/2014 |
| Our findings indicate that Int6 act as a hypoxia-independent master switch of angiogenesis in neuronal cells | Int6 silencing causes induction of angiogenic factors in neuronal cells via accumulation of hypoxia-inducible factor 2α and decreases brain damage in rats.
Miyashita R, Chen L, Oshiro H, Uchino H, Shibasaki F. | 05/3/2014 |
| eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. | Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.
Villa N, Do A, Hershey JW, Fraser CS., Free PMC Article | 01/25/2014 |
| novel role of eIF3e/Int6 in the regulation of EMT in breast epithelial cells | Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.
Gillis LD, Lewis SM. | 10/19/2013 |
| IL-6 and IL-8 are HIF2alpha controlled cytokines for angiogenesis particularly in endothelial cells. | Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling.
Endler A, Chen L, Li Q, Uchida K, Hashimoto T, Lu L, Xu GT, Shibasaki F. | 09/14/2013 |
| HTLV-1Tax binds both INT6 and UPF1. The analysis of Tax mutants indicated that the Tax-INT6 association is necessary for nonsense-mediated mRNA decay inhibition, and data suggest that Tax sequesters INT6 out of reach from UPF1. | The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.
Mocquet V, Neusiedler J, Rende F, Cluet D, Robin JP, Terme JM, Duc Dodon M, Wittmann J, Morris C, Le Hir H, Ciminale V, Jalinot P., Free PMC Article | 09/15/2012 |
| INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs. | INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.
Neusiedler J, Mocquet V, Limousin T, Ohlmann T, Morris C, Jalinot P., Free PMC Article | 07/28/2012 |
| findings reveal unexpected and striking connections of INT6 with ATM and BRCA1 | INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.
Morris C, Tomimatsu N, Richard DJ, Cluet D, Burma S, Khanna KK, Jalinot P., Free PMC Article | 06/2/2012 |
| Int6 depletion blocks ubiquitin-dependent proteolysis by decreasing both ubiquitin levels and the assembly of functional proteasome machinery, leading to accumulation of oncoproteins, such as SRC3. | Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.
Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC., Free PMC Article | 04/9/2011 |
| data suggest that eIF3e has a positive role in breast cancer progression. It regulates the translation, and in some cases abundance, of mRNAs involved in key aspects of cancer cell biology | An oncogenic role of eIF3e/INT6 in human breast cancer.
Grzmil M, Rzymski T, Milani M, Harris AL, Capper RG, Saunders NJ, Salhan A, Ragoussis J, Norbury CJ. | 08/16/2010 |
| INT6 stabilizes chromatin-bound MCM7 and alteration of this effect is associated with replication deficiency. | Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.
Buchsbaum S, Morris C, Bochard V, Jalinot P. | 01/21/2010 |
| eIF3e binds to eIF4G during the process of cap-dependent translation initiation | Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.
LeFebvre AK, Korneeva NL, Trutschl M, Cvek U, Duzan RD, Bradley CA, Hershey JW, Rhoads RE., Free PMC Article | 01/21/2010 |
| EIF3e/INT6 is localized in part to the nucleus, while other eIF3 components are cytoplasmic. Primary human fibroblasts showed reduced nuclear INT6 staining in early S phase. | Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.
Watkins SJ, Norbury CJ., Free PMC Article | 01/21/2010 |
| Results suggest that Int6 expression, evaluated by quantitative real-time PCR, may represent a new prognostic factor in patients with stage I non-small cell lung cancers. | Int6 expression can predict survival in early-stage non-small cell lung cancer patients.
Buttitta F, Martella C, Barassi F, Felicioni L, Salvatore S, Rosini S, D'Antuono T, Chella A, Mucilli F, Sacco R, Mezzetti A, Cuccurullo F, Callahan R, Marchetti A. | 01/21/2010 |