| using a gain-of-function mutation that constitutively activates the channel, we present an X-ray structure of Drosophila melanogaster Orai in an open conformation. Well-defined electron density maps reveal that the pore is dramatically dilated on its cytosolic side in comparison to the slender closed pore. | Structures reveal opening of the store-operated calcium channel Orai.
Hou X, Burstein SR, Long SB., Free PMC Article | 01/12/2019 |
| Ca2+ uptake in neurons with reduced SEPT7 requires Orai. | Store-independent modulation of Ca(2+) entry through Orai by Septin 7.
Deb BK, Pathak T, Hasan G., Free PMC Article | 11/4/2017 |
| after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry. | Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.
Chakraborty S, Deb BK, Chorna T, Konieczny V, Taylor CW, Hasan G., Free PMC Article | 08/5/2017 |
| These studies suggest that modulation of SOCE could serve as a novel mechanism for restoring dopamine levels in dopaminergic neurons. | Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila.
Pathak T, Agrawal T, Richhariya S, Sadaf S, Hasan G., Free PMC Article | 01/16/2016 |
| Data indicate that STIM functions as sensors of Ca2+ stored in the endoplasmic reticulum (ER) lumen and translocate into ER-PM (plasma membrane) junctions to tether and activate Orai channels when ER Ca2+ concentration decreases. | Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.
Rothberg BS, Wang Y, Gill DL., Free PMC Article | 09/21/2013 |
| The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. | Crystal structure of the calcium release-activated calcium channel Orai.
Hou X, Pedi L, Diver MM, Long SB., Free PMC Article | 12/22/2012 |
| Interaction with the C terminus of Stim thus induces Orai dimers to dimerize, forming tetramers that constitute the Ca(2+)-selective pore. | The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.
Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD., Free PMC Article | 01/21/2010 |
| results demonstrate that the protein CRACM1 encoded by olf186-F is essential for store-operated Ca2+ influx via Ca2+ release-activated Ca2+ (CRAC) channels | CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP., Free PMC Article | 01/21/2010 |
| results indicate that Orai itself forms the Ca2+-selectivity filter of the CRAC channel | Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.
Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD., Free PMC Article | 01/21/2010 |
| Orai1 is an essential component or regulator of the CRAC channel complex | A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. | 01/21/2010 |
| The human ortholog of drosophila olf186-F interacts with STIM1 to regulate the amplitude of store-operated calcium entry. | Amplification of CRAC current by STIM1 and CRACM1 (Orai1).
Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP., Free PMC Article | 06/7/2006 |