| cell polarity disruption activates JNK signaling, which in turn upregulate Wingless expression through transcription factor activator protein-1 | Wingless modulates activator protein-1-mediated tumor invasion.
Zhang S, Guo X, Wu H, Sun Y, Ma X, Li J, Xu Q, Wu C, Li Q, Jiang C, Li W, Ho MS, Lv Z, Xue L. | 12/7/2019 |
| c-Fos/CREB cycling defines long-term memories (LTM) engram cells required for LTM. | Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.
Miyashita T, Kikuchi E, Horiuchi J, Saitoe M. | 11/16/2019 |
| In wild-type ovarian cells, c-Fos is post-transcriptionally repressed by Piwi, which destabilized the c-Fos mRNA by promoting the processing of its 3' untranslated region (UTR) into Piwi-interacting RNAs (piRNAs). | c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis.
Klein JD, Qu C, Yang X, Fan Y, Tang C, Peng JC., Free PMC Article | 05/13/2017 |
| malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase. | Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
Külshammer E, Mundorf J, Kilinc M, Frommolt P, Wagle P, Uhlirova M., Free PMC Article | 07/30/2016 |
| AP-1-dependent gene transcription is upregulated by increased neural activity during development. | Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.
Vonhoff F, Kuehn C, Blumenstock S, Sanyal S, Duch C., Free PMC Article | 03/9/2013 |
| Ebi/AP-1 suppresses basal transcription levels of apoptotic genes and thereby protects sensory neurons from degeneration | Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Lim YM, Hayashi S, Tsuda L., Free PMC Article | 11/3/2012 |
| Clathrin and AP-1 colocalize at the trans-Golgi network; clathrin and AP-1 colocalize with secretory cargo at the TGN and on immature granules; loss of clathrin or AP-1 leads to a profound block in secretory granule formation. | AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila.
Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis PA, Boulianne GL, Chang HC, Le Borgne R, Krämer H, Brill JA., Free PMC Article | 12/10/2011 |
| It was shown that the AP-1 complex causes apical accumulation of the Notch activator Sanpodo and stabilization of both Sanpodo and Notch at the interface between sense organ precursor daughter cells. | AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors.
Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. | 05/21/2011 |
| AP-1 mediated synapse enhancement and its relationship to increases in synapse number, Ca2+ influx, Ca2+ sensitivity of vesicle fusion or synaptic vesicle number, were examined. | Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse.
Kim SM, Kumar V, Lin YQ, Karunanithi S, Ramaswami M., Free PMC Article | 01/21/2010 |
| expression of Fos bZip elicits male-specific phenotypes. | A male-specific effect of dominant-negative Fos.
Pierre W, Morra R, Lucchesi J, Yedvobnick B. | 01/21/2010 |
| In Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) signaling cascade. | Raw mediates antagonism of AP-1 activity in Drosophila.
Bates KL, Higley M, Letsou A., Free PMC Article | 01/21/2010 |
| excess of JNK signaling is deleterious for migration in the absence of PVR activity at least in part through Fos transcriptional activity and possibly through antagonistic effects on DIAP1. | A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila.
Mathieu J, Sung HH, Pugieux C, Soetaert J, Rorth P., Free PMC Article | 01/21/2010 |
| Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. | Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.
Luo X, Puig O, Hyun J, Bohmann D, Jasper H., Free PMC Article | 01/21/2010 |
| We identified cyclin B as a direct transcriptional target of Fos in Drosophila melanogaster, with Fos binding to a region upstream of the cyclin B gene in vivo and cyclin B mRNA being specifically reduced under Fos loss-of-function conditions. | Control of G2/M transition by Drosophila Fos.
Hyun J, Bécam I, Yanicostas C, Bohmann D., Free PMC Article | 01/21/2010 |