| Clinicopathological Significance of DUB3 Expression in Non-small Cell Lung Cancer and Relationship Between DUB3 Expression and LATS1 Expression. | Clinicopathological Significance of DUB3 Expression in Non-small Cell Lung Cancer and Relationship Between DUB3 Expression and LATS1 Expression.
Jang SH, Cho HD, Lee JH, Oh MH., Free PMC Article | 11/6/2023 |
| USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells. | USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.
Su Y, Wu C, Chang Y, Li L, Chen Y, Jia X, Wang X, Lv Y, Yu B, Yuan J. | 10/15/2022 |
| NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3. | NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.
Zhang Y, Zuo D, Qiu J, Li K, Niu Y, Yuan Y, Qiu Y, Qiao L, He W, Wang C, Yuan Y, Li B., Free PMC Article | 08/13/2022 |
| DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer. | DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer.
Zhang Q, Zhang ZY, Du H, Li SZ, Tu R, Jia YF, Zheng Z, Song XM, Du RL, Zhang XD., Free PMC Article | 09/12/2020 |
| DUB3 functions as a novel cyclin A regulator through maintaining cyclin A stability. | Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.
Hu B, Deng T, Ma H, Liu Y, Feng P, Wei D, Ling N, Li L, Qiu S, Zhang L, Peng B, Liu J, Ye M., Free PMC Article | 11/30/2019 |
| further analysis revealed 2 hemizygous deletions in the grandmother that segregate in several of her affected offspring. The first deletion was found in the UGT2B28 locus, spanning 7 informative sequence variants across at least 14 kb. The second deletion, located in USP17L2, spans 3 informative variants across at least 2 kb. On the whole, the findings of the presents study implicate 2 additional genes in the pathogenesis | Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.
Albertsen HM, Matalliotaki C, Matalliotakis M, Zervou MI, Matalliotakis I, Spandidos DA, Chettier R, Ward K, Goulielmos GN., Free PMC Article | 05/25/2019 |
| our results revealed the essential role of the MGMT-DUB3-MCL1 axis in the chemoresistance of ovarian cancer and identified that a combined treatment with HDACis and PaTrin-2 is an effective method for overcoming chemoresistance in ovarian cancer. | MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.
Wu X, Luo Q, Zhao P, Chang W, Wang Y, Shu T, Ding F, Li B, Liu Z., Free PMC Article | 05/4/2019 |
| DUB3 promotes BET inhibitor resistance and cancer progression by deubiquitinating BRD4. | DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.
Jin X, Yan Y, Wang D, Ding D, Ma T, Ye Z, Jimenez R, Wang L, Wu H, Huang H., Free PMC Article | 03/23/2019 |
| Dub3 is identified as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. | Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.
Wu Y, Wang Y, Lin Y, Liu Y, Wang Y, Jia J, Singh P, Chi YI, Wang C, Dong C, Li W, Tao M, Napier D, Shi Q, Deng J, Evers BM, Zhou BP., Free PMC Article | 11/10/2018 |
| these data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein stability, and suggest that USP7 may be involved in Geminin dysregulation during breast cancer progression. | DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
Hernández-Pérez S, Cabrera E, Salido E, Lim M, Reid L, Lakhani SR, Khanna KK, Saunus JM, Freire R. | 10/14/2017 |
| We provide evidence that DUB3 proteins regulate YAP/TAZ activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT family proteins. As a novel Hippo pathway regulator, DUB3 has the potential to act a tumor suppressor by limiting YAP activity. | DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins.
Nguyen HT, Kugler JM, Cohen SM., Free PMC Article | 08/19/2017 |
| In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17. | USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation.
Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D, Li B, Shi G., Free PMC Article | 10/1/2016 |
| These data indicate that the Dub3 might be a valuable biomarker for the prediction of ovarian cancer prognosis and Dub3 inhibition might be a potential strategy for ovarian cancer treatment. | Dub3 expression correlates with tumor progression and poor prognosis in human epithelial ovarian cancer.
Zhou B, Shu B, Xi T, Su N, Liu J. | 02/13/2016 |
| Dub3 counteracts H2AX E3 ligases RNF8 and RNF168. Moreover, Dub3 and H2AX interact and Dub3 deubiquitinates H2AX in vitro. | Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.
Delgado-Díaz MR, Martín Y, Berg A, Freire R, Smits VA., Free PMC Article | 02/28/2015 |
| Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] | Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes.
Lim KH, Ramakrishna S, Baek KH. | 04/26/2014 |
| As a major regulator of Cdc25A, Dub3 is an example of a transforming ubiquitin hydrolase that subverts a key component of the cell cycle machinery, promoting oncogenic transformation. | Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.
Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM. | 05/3/2010 |
| Identifies DUB3 as being one of 30 genes with the most variable copy numbers in three human genomes. | Personalized copy number and segmental duplication maps using next-generation sequencing.
Alkan C, Kidd JM, Marques-Bonet T, Aksay G, Antonacci F, Hormozdiari F, Kitzman JO, Baker C, Malig M, Mutlu O, Sahinalp SC, Gibbs RA, Eichler EE., Free PMC Article | 09/1/2009 |
| human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation. | DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.
Burrows JF, McGrattan MJ, Rascle A, Humbert M, Baek KH, Johnston JA. | 01/21/2010 |