| Study demonstrated that UII and URP binding sites are totally overlapping and that these sites were functional in regions bordering the fourth ventricle; data support a role for UII/URP at the interface between brain parenchyma and cerebrospinal fluid | Concordant localization of functional urotensin II and urotensin II-related peptide binding sites in the rat brain: Atypical occurrence close to the fourth ventricle.
Bucharles C, Bizet P, Arthaud S, Arabo A, Leprince J, Lefranc B, Cartier D, Anouar Y, Lihrmann I. | 02/14/2015 |
| U-II and URP can differentially modulate nuclear UT functions such as gene expression, and both ligands can reach the internal cellular space through a receptor-independent mechanism | Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
Doan ND, Nguyen TT, Létourneau M, Turcotte K, Fournier A, Chatenet D., Free PMC Article | 08/11/2012 |
| remarkable cellular and subcellular distribution led us to test the effect of URP on the GnRH-induced gonadotrophins release in the anterior pituitary, and to discuss its putative role at the level of the median eminence | Direct evidence for the co-expression of URP and GnRH in a sub-population of rat hypothalamic neurones: anatomical and functional correlation.
Egginger JG, Parmentier C, Garrel G, Cohen-Tannoudji J, Camus A, Calas A, Hardin-Pouzet H, Grange-Messent V., Free PMC Article | 03/3/2012 |
| In the aorta, expression levels of urotensin II-related peptide mRNA was significantly elevated in 11-12-week-old SHR compared with age-matched WKY, similarly to those in the kidney. | Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1.
Hirose T, Takahashi K, Mori N, Nakayama T, Kikuya M, Ohkubo T, Kohzuki M, Totsune K, Imai Y. | 01/21/2010 |
| Increased expression of urotensin II-related peptide in kidney with hypertension or renal failure | Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure.
Mori N, Hirose T, Nakayama T, Ito O, Kanazawa M, Imai Y, Kohzuki M, Takahashi K, Totsune K. | 01/21/2010 |
| SHR are more sensitive than WKY rats to UII, which acts primarily to lower glomerular filtration rate thus favoring salt retention in this model of hypertension | Enhanced renal sensitivity of the spontaneously hypertensive rat to urotensin II.
Abdel-Razik AE, Balment RJ, Ashton N. | 01/21/2010 |
| Data suggest that urotensin II and urotensin II-related peptide reduce cardiac ischemia-reperfusion injury by increasing flow through the coronary circulation, reducing contractility and energy demand, and inhibiting reperfusion myocardial damage. | Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury.
Prosser HC, Forster ME, Richards AM, Pemberton CJ. | 01/21/2010 |
| Data suggest that the expression of urotensin II-related peptide, urotensin II and urotensin II receptor is enhanced in failing heart, and the UII/URP/UT-R system has important pathophysiological roles in the progression of heart failure. | Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure.
Nakayama T, Hirose T, Totsune K, Mori N, Maruyama Y, Maejima T, Minagawa K, Morimoto R, Asayama K, Kikuya M, Ohkubo T, Hashimoto J, Kohzuki M, Takahashi K, Imai Y. | 01/21/2010 |
| These results suggest that urotensin II-related peptide is the endogenous and functional ligand for the urotensin II receptor GPR14 in the rat and mouse, and possibly in the human. | Another ligand fishing for G protein-coupled receptor 14. Discovery of urotensin II-related peptide in the rat brain.
Sugo T, Mori M. | 01/21/2010 |
| The long-lasting vasoconstriction induced by hU-II alone is PKC dependent and associated with PKC-theta phosphorylation. | Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction.
Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC. | 01/21/2010 |
| URP is the endogenous and functional ligand for UII receptor in the rat | Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.
Sugo T, Murakami Y, Shimomura Y, Harada M, Abe M, Ishibashi Y, Kitada C, Miyajima N, Suzuki N, Mori M, Fujino M. | 01/21/2010 |
| URP is the endogenous and functional ligand for urotensin II receptor in the rat. (REVIEW) | Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain.
Mori M, Fujino M. | 01/21/2010 |
| central urotensin II may play a role in the pathogenesis of hypertension in SHR rats | Central cardiovascular action of urotensin II in spontaneously hypertensive rats.
Lin Y, Tsuchihashi T, Matsumura K, Fukuhara M, Ohya Y, Fujii K, Iida M. | 01/21/2010 |